Master Degree / Yüksek Lisans Tezleri
Permanent URI for this collectionhttps://hdl.handle.net/11147/3008
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Master Thesis Desing and Synthesis of Fluorescent Chemodosimeter for the Analysis of the Gold Ions(Izmir Institute of Technology, 2018) Çevik Eren, Merve; Emrullahoğlu, MustafaThe gold element has been used in many different areas throughout history. This includes the treatment of various diseases with drugs containing gold. In contrast to gold metal, gold ions are known to be extremely harmful to the human body. Therefore, the determination of the gold ions in the human body is very important. Gold ion determination can be made by using expensive spectroscopic methods. In contrast to highly expensive spectroscopic methods, chemosensors with high sensitivity and selectivity are a good option to make the gold determination. The bodipy fluorophore is a good example for the metal ion chemosensor. In this study, a bodipybased fluorescence sensor derived from a unique motif that has a triple bond was designed and synthesized. By activating the triple bond of the gold ions, it becomes selective to the gold ions as a result of ırreversible intramolecular cycling.Master Thesis Desing and Synthesis of Fluorescein Based Gold Ion Sensors(Izmir Institute of Technology, 2016) Çetintaş, Ceyla; Emrullahoğlu, MustafaGold has been a part of people’s lives for ages and is used as money, goods and jewellery. In recent years, gold has played a key role in chemistry, medicine and biology. Since the 1970s, gold has been extensively used as a catalyst in several chemical transformations. Due to its high biocompatibility, functionalized gold nanoparticles have been extensively employed as drug and gene delivery systems, biosensors and bio-imaging materials. However, gold complexes can become toxic to the human body by interacting with biomolecules such as DNA and enzymes. Therefore, detection of trace amounts of gold species is an important issue and can be achieved via spectroscopic methods such as atomic absorption spectroscopy, atomic emission spectroscopy and inductively coupled plasma spectrometry. However, these analytical methods require complicated sample preparation steps and sophisticated instrumentation. In contrast to these extremely expensive and time-consuming methods, fluorogenic or chromogenic methods, which provide high analyte sensitivity and selectivity, can serve as good alternatives for detecting gold species. To develop new probes for the detection of Au3+ ions, we focused on the design of new fluorescein-based probes that are soluble in aqueous media. We aimed to investigate the in vivo activity of these fluorescent probes. In the proposed detection system, gold ions are expected to mediate a chemical reaction through coordination to an alkyne moiety that results in a ring opening reaction to yield a highly fluorescent derivative.