Master Degree / Yüksek Lisans Tezleri

Permanent URI for this collectionhttps://hdl.handle.net/11147/3008

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Access type: Open accessSubject: search.filters.subject.Gold ions

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  • Master Thesis
    Fluorescent Gold Ion Sensors: Design, Synthesis and Imaging
    (01. Izmir Institute of Technology, 2021) Kaya, Beraat Umur; Emrullahoğlu, Mustafa
    Of all transition metals, gold has long sustained attention owing to its unique chemical and physical properties. Beyond that, the ease of processing gold allows its use in science, industry, and in various chemical, biological, and medical applications. For example, gold is used in medicine to treat rheumatoid arthritis, asthma, cancer, and brain and skin lesions. However, the extensive use of gold compounds can adversely impact the natural environment and biological systems due to their potential toxicity. For those reasons, identifying trace amounts of gold species in solution and cell media is crucial. Unlike the detection methods of atomic absorption spectroscopy, atomic emission spectroscopy, and inductively coupled plasma spectrometry, fluorescence-based detection methods offer easy sample preparation, rapid response, high sensitivity, reproducibility, and efficiency, all at a low cost. Today, various types of fluorescent sensors selective to gold ions have been designed, typically with BODIPY, fluorescein, rhodamine, naphthalimide, and coumarin-based fluorophores. In the work for this thesis, for the first time an enyne-derived BODIPY-based sensor was designed and synthesised to identify Au3+ ions, after which photophysical changes in the presence and absence of the analyte were examined both in solutions and in cells.
  • Master Thesis
    Desing and Synthesis of Fluorescent Chemodosimeter for the Analysis of the Gold Ions
    (Izmir Institute of Technology, 2018) Çevik Eren, Merve; Emrullahoğlu, Mustafa
    The gold element has been used in many different areas throughout history. This includes the treatment of various diseases with drugs containing gold. In contrast to gold metal, gold ions are known to be extremely harmful to the human body. Therefore, the determination of the gold ions in the human body is very important. Gold ion determination can be made by using expensive spectroscopic methods. In contrast to highly expensive spectroscopic methods, chemosensors with high sensitivity and selectivity are a good option to make the gold determination. The bodipy fluorophore is a good example for the metal ion chemosensor. In this study, a bodipybased fluorescence sensor derived from a unique motif that has a triple bond was designed and synthesized. By activating the triple bond of the gold ions, it becomes selective to the gold ions as a result of ırreversible intramolecular cycling.
  • Master Thesis
    Desing and Synthesis of Fluorescein Based Gold Ion Sensors
    (Izmir Institute of Technology, 2016) Çetintaş, Ceyla; Emrullahoğlu, Mustafa
    Gold has been a part of people’s lives for ages and is used as money, goods and jewellery. In recent years, gold has played a key role in chemistry, medicine and biology. Since the 1970s, gold has been extensively used as a catalyst in several chemical transformations. Due to its high biocompatibility, functionalized gold nanoparticles have been extensively employed as drug and gene delivery systems, biosensors and bio-imaging materials. However, gold complexes can become toxic to the human body by interacting with biomolecules such as DNA and enzymes. Therefore, detection of trace amounts of gold species is an important issue and can be achieved via spectroscopic methods such as atomic absorption spectroscopy, atomic emission spectroscopy and inductively coupled plasma spectrometry. However, these analytical methods require complicated sample preparation steps and sophisticated instrumentation. In contrast to these extremely expensive and time-consuming methods, fluorogenic or chromogenic methods, which provide high analyte sensitivity and selectivity, can serve as good alternatives for detecting gold species. To develop new probes for the detection of Au3+ ions, we focused on the design of new fluorescein-based probes that are soluble in aqueous media. We aimed to investigate the in vivo activity of these fluorescent probes. In the proposed detection system, gold ions are expected to mediate a chemical reaction through coordination to an alkyne moiety that results in a ring opening reaction to yield a highly fluorescent derivative.