Master Degree / Yüksek Lisans Tezleri

Permanent URI for this collectionhttps://hdl.handle.net/11147/3008

Browse

Filters

20221

Settings

Author: search.filters.author.Başer, FilizSubject: search.filters.subject.Colon cancer

Search Results

Now showing 1 - 1 of 1
  • Master Thesis
    Investigation of the biological health potency of fig stalk waste pectin for colon cancer cell growth and intestinal glucose absorption
    (Izmir Institute of Technology, 2022) Yemenicioğlu, Ahmet; Güleç, Şükrü; Başer, Filiz; Güleç, Şükrü; Yemenicioğlu, Ahmet; 03.08. Department of Food Engineering; 03. Faculty of Engineering; 01. Izmir Institute of Technology
    Higher intake of dietary fiber is correlated with reduced obesity-related disorders such as cardiovascular diseases and diabetes, improved gut health, and protection against colorectal cancer. Pectin comes from plant cell walls and is mainly composed of galacturonic acid units branched with neutral sugars that provide bioactive and functional properties. Pectin has long been appreciated in the food industry due to its viscous structure and gelling properties. Dietary pectin as a soluble fiber is linked with cancer and metabolic health. Anti-cancer activity of pectin is promising in multiple types of cancer in humans and animals by inducing cellular apoptosis and inhibiting tumor metastasis. Soluble dietary pectin regulates blood glucose levels, sparking interest in diabetes prevention and treatment. Fig stalk waste was used as an unconventional pectin source in the present study, providing a promising green option. The health benefit of fig stalk waste pectin (FSWP) was investigated in terms of colon cancer cell growth and intestinal glucose absorption. The inhibitory effects of FSWP on colon cancer Caco-2 cells were further confirmed with cell cycle analysis and apoptotic cell death. Intestinal glucose absorption was modeled with Caco-2 enterocyte uptake and transport systems. FSWP inhibited 2-deoxyglucose uptake into Caco-2 cells and reduced glucose absorption as a food ingredient in the intestinal transport system. Taken together, FSWP has promising bioactivity against colon cancer and could be used as a functional food additive due to its inhibitory effect on intestinal glucose absorption.