Master Degree / Yüksek Lisans Tezleri

Permanent URI for this collectionhttps://hdl.handle.net/11147/3008

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  • Master Thesis
    Investigations on Surface Electric Charge of Silica Nanoparticles With Different Surface Roughnesses
    (Izmir Institute of Technology, 2019) Alan, Büşra Öykü; Barışık, Murat; Barışık, Murat; 03.10. Department of Mechanical Engineering; 03. Faculty of Engineering; 01. Izmir Institute of Technology
    Silica nanoparticles have been receiving more attention from diverse research areas recently due to their significant physical properties such as large pore volume and high internal surface area, colloidal stability, high biocompatibility, and tunable pore sizes. These silica nanoparticles are great candidates for drug delivery applications because they can transport a large amount of drugs into selective organs and tissues due to their high surface area and large pore volume. However, there are important drug delivery mechanisms that need to be understood properly such as cellular uptake, endosomal escape, drug loading and release, and crossing physical barriers. Physicochemical properties of nanoparticles (size, shape, surface charge, or surface chemistry) are important for understanding these mechanisms in order to develop successful drug delivery applications. This research investigates how these surface charge properties change with different particle, pore diameters, roughness structure on the nanoparticle surface, and different temperature and solution conditions. Also, we investigate how the surface charging behavior of rough nanoparticles interacts with a flat plate. Rough nanoparticles and their interactions with surfaces theoretical assumptions can be wrong and ionic distribution can show variation locally. In order to calculate ionic distribution and surface charge properties in these systems, proper equations and boundary conditions were employed. The charge regulation model was used as a boundary condition because of the electric double layer overlap effect. Results showed that there was a considerable variation on surface charge properties due to the roughness structure with different roughness and particle sizes and temperature difference.
  • Master Thesis
    Optimization of Surface Roughness on a Milling Process Using Stochastic Methods
    (Izmir Institute of Technology, 2019) Dinç, Özcan; Artem, Hatice Seçil; Artem, Hatice Seçil; 03.10. Department of Mechanical Engineering; 03. Faculty of Engineering; 01. Izmir Institute of Technology
    Nowadays, milling process is one of the most widely used metal processing methods in many fields from space and aircraft to automotive industry. The surface roughness values of the workpiece in milling process vary depending on the thermal, chemical and abrasive loads that occur during cutting. Spindle speed, depth of cut and feed rate are the cutting parameters affecting the surface roughness. Hence, these parameters at the time of machining constitute an important issue. Accordingly, in this thesis optimization of surface roughness has been performed using the stochastic search methods. First, using experimental data obtained in the milling process, it was aimed to establish a regression model to determine average surface roughness equation as an objective function. The cutting parameters and average surface roughness value were considered as input and output in regression analysis, respectively. In this study, seven different mathematical models have been established and examined to carry out regression analysis. The reliability and stability of the mathematical models were investigated. The most appropriate mathematical model has been constructed and then used as an objective function for optimization. Nelder-Mead, Random-Search, Simulated Annealing, and Differential Evolution were the stochastic search algorithms to perform the optimization in the present study. In conclusion, it was found that the minimum average surface roughness value depends on spindle speed, depth of cut and feed parameters.