Master Degree / Yüksek Lisans Tezleri

Permanent URI for this collectionhttps://hdl.handle.net/11147/3008

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Language: search.filters.language.enSubject: search.filters.subject.Biomedical engineering

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  • Master Thesis
    Magnetic-Based Cell Manipulation in Microfluidic Devices
    (01. Izmir Institute of Technology, 2022) Tekin, Hüseyin Cumhur; Tekin, Hüseyin Cumhur; 03.01. Department of Bioengineering; 03. Faculty of Engineering; 01. Izmir Institute of Technology
    Cell manipulation is the concept of altering cell movement. Different manipulation techniques have been demonstrated with microfluidic systems for various studies such as tissue engineering, circulating tumor cell (CTC) filtering, and other biomedical applications. For instance, cell patterning and filtering studies are being developed through different manipulation approaches in microfluidic platforms where one of these approaches is the magnetophoresis principle method. Positive and negative magnetophoresis can be utilized generally through labeling or non-labeling, respectively. In this thesis, two different cell manipulation platforms using negative magnetophoresis were developed for cell patterning and cell filtration applications. These platforms allow several advantages such as simple fabrication, easy control, and low cost. Compared to other devices, the developed microfluidic platforms do not require any labeling process for cells for magnetic manipulation. In the patterning platform, microparticle and cell patterns were formed inside a simple microfluidic channel with different tilted angles in <1.5 hours. Furthermore, in the filtration platform, large microparticles were separated from small microparticles with 98.25% trapping efficiency. Live/dead cell separation of human monocyte macrophage cells (U937) under different flow rates was also investigated. The suggested platforms could be useful for label-free magnetic cell patterning and filtering in biomedical applications.
  • Master Thesis
    Assessment and Certification of Safety Critical Software
    (Izmir Institute of Technology, 2018) Uzun Yenigün, Bengisu; Ayav, Tolga; Ayav, Tolga; 03.04. Department of Computer Engineering; 03. Faculty of Engineering; 01. Izmir Institute of Technology
    Biomedical engineering which consists of combination of various dicipline such as chemical, biology etc. produces remedies to the challenges facing the globalizing world. Therefore, it covers a wide range of area from biosensor to surgical robots. Rapid development of biomedical engineering technology is aimed to research, diagnose and treatment to modern society for providing improved living conditions. Safety critical systems are interested with systems whose failure or malfunction could cause death, serious injury, damage to equipment and environmental harm. NeuRoboScope project is a safety-critical system which navigates the optical-camera system used in the endoscopic pituitary surgery by tracking the surgery tool that the surgeon uses. This thesis gives the information of how we scrutinize NeuRoboScope project depending on standards of medical device which are ISO 14971, IEC 62304, IEC 60601 and DO-178C.