Master Degree / Yüksek Lisans Tezleri
Permanent URI for this collectionhttps://hdl.handle.net/11147/3008
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Master Thesis Testing of Antidiabetic Features of Formulated Food Products in Enterocyte Cell Culture Model(Izmir Institute of Technology, 2017) Pilatin, Gözde; Güleç, ŞükrüIn recent years, there has been an increasing interest in designing low calorie functional foods that might have health benefit against development of obesity and T2D. However, researches on developing low calorie foods in Turkey are quite insufficient. Even if the products are developed, in vitro and in vivo approaches to design low calorie foods are not carried out properly. Thus, we aimed to test diabetic features of newly formulated low calorie and no-added sugar containing cake, almond paste and pudding in intestinal cell culture system. Cake, almond paste and pudding were developed by “Egepak Gıda ve Ambalaj San.” and same type foods were chosen from market to use as reference. We modeled human carbohydrates digestive systems in test tube and relative glucose efflux were measured from rat enterocyte cells that were grown on bicameral cell culture system. Bioaccessibility of glucose was found at least 61%, 89% and 64% lower in cake, almond paste and pudding respectively relative to references. The levels of cellular glucose efflux were significantly lower from 30min (for cake 1.9 fold; for almond paste 4.3; for pudding 3.3 fold) to 120 min (for cake 2.2 fold; for almond paste 3.7 fold) to 180 min (for pudding 2.0 fold) in products than their references. To the best of our knowledge, this is the first exemplary study in Turkey to develop newly formulated foods by analyzing their diabetic features in in vitro model of human intestine system.Master Thesis Development of Novel Functional Foods From Turkish Kabuli Type Chickpeas(Izmir Institute of Technology, 2015) Şahin, Damla Öykü; Yemenicioğlu, Ahmet; Yemenicioğlu, AhmetThe aim of this thesis is to obtain novel functional chickpea and chickpea products by incorporating bioactive green and black tea phenolics into Turkish Kabuli type chickpeas during controlled rehydration. The rehydration of chickpeas in green or black tea infusions and green tea extracts increased the total phenolic content and bioactive properties of chickpeas. Chickpeas rehydrated in green tea extract or green tea infusions for 2 hours showed almost 2.2 2.5 fold higher total phenolic content, flavonoid content and free radical scavenging based antioxidant capacity, and rehydrated in green tea extract, green tea or black tea infusions almost 2.2-2.6 fold higher antidiabetic activity than control chickpeas rehydrated in water. The increase of rehydration period from 2h to 10h could increase the total phenolic content and antioxidant activity of chickpeas, but the increased incubation period did not have any considerable positive effects on antidiabetic activity of chickpeas. No significant reductions were o served in total phenolic content, flavonoid content and antio idant activity of phenolic enriched chickpeas kept frozen at 18°C while some limited reductions were observed in phenolic content and antioxidant activity of phenolic enriched chickpeas dried and stored at +4°C for 3 months. The extraction and then characterization of the phenolic content, and antioxidant and antidiabetic activity of protein from phenolic enriched chickpeas clearly showed the binding of the incorporated phenolic compounds onto chickpea protein. Thus, it appeared that the protein extracted from phenolic enriched chickpeas could also be used as a functional food ingredient. This work clearly showed the possibility of obtaining functional chickpeas and chickpea protein by use of controlled rehydration in presence solutions containing green and black tea phenolics.