Master Degree / Yüksek Lisans Tezleri
Permanent URI for this collectionhttps://hdl.handle.net/11147/3008
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Master Thesis Investigating the Regulatory Role of Lysosomal Protein Cathepsin a in Vasoactive Peptide Biology(Izmir Institute of Technology, 2016) Çalhan, Osman Yipkin; Seyrantepe, Volkan; Seyrantepe, Volkan; 04.03. Department of Molecular Biology and Genetics; 04. Faculty of Science; 01. Izmir Institute of TechnologyThe lysosomal carboxypeptidase A, Cathepsin A (CathA), is a serine protease with distinct functions. CathA protects sialidase Neu1 and β- galactosidase against proteolytic degradation by forming a multi-enzyme complex and was shown to be activating sialidase Neu1. Mutations in the CathA gene cause the lysosomal storage disease galactosialidosis. Patients with galactosialidosis are characterized with a broad range of clinical phenotypes, involving growth retardation, neurological deterioration and accumulation of vasoactive peptide, endothelin-1 in the brain. CathA is also a multi-catalytic enzyme with deamidase and esterase activity at neutral pH, and carboxypeptidase activity at acidic pH. Previous investigations have presented that CathA has specific enzyme activity against vasoactive and neuropeptides, including endothelin-1, oxytocin and substance P. A generated mouse model with inactive CathA enzyme activity (CathAS190A) showed significantly increased level of precursor endothelin-1 vasoactive peptide with increased arterial blood pressure. The aim of this study was to ascertain the regulatory role of CathA against other vasoactive peptide precursors such as oxytocin, endothelin-1 and substance P in vivo. In addition to the regulatory role of the enzyme, CathA’s involvement in learning ability, long term memory and motor cortex functioning was elucidated. Our results showed that CathA has a regulatory role on endothelin-1 and oxytocin peptides’ degradation, which is the reason of the increased accumulation in the brain hippocampus region for CathAS190A. Memory based Morris’ water maze and passive avoidance tests illustrated that CathAS190A animals had lower scores than control littermates, which let us to speculate that CathA may play significant role in memory consolidation and learning ability through its regulatory role on vasoactive peptide biology.Master Thesis Brain Dynamics and Memory Enhancement: Memristor Based Models(Izmir Institute of Technology, 2014) Yücel, Ufuk; Savacı, Ferit Acar; Savaci, Ferit Acar; 03.05. Department of Electrical and Electronics Engineering; 03. Faculty of Engineering; 01. Izmir Institute of TechnologyIn this thesis, the memory systems of the brain are researched and the relationship between these memory systems and memristor theory are studied. Firstly, the ideal memristor theory is studied. By using the cubic memristor that was based on the ideal memristor theory, the basic logical operations are explained. Additionally, the nerve cells and synapses, which are thought where the memory and learning take place, are inquired. Bearing in mind that the characteristic of the memristor and its similarities between the synapses has been researched with the previous studies on this field. Finally, memristor data storage system has been designed by using memristors, and a binary image of 12x60 pixels has been successfully stored on this design. Also, the edge detection for images has been presented by using the memristor cellular automaton and some examples have also been given.