Master Degree / Yüksek Lisans Tezleri

Permanent URI for this collectionhttps://hdl.handle.net/11147/3008

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Subject: search.filters.subject.Biomedical applications

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  • Master Thesis
    Development of Mitochondria Targeted Gold Nanorods
    (Izmir Institute of Technology, 2019) Uçak, Hande; Özçelik, Serdar; Özçelik, Serdar; 04.01. Department of Chemistry; 04. Faculty of Science; 01. Izmir Institute of Technology
    Lung cancer has the largest number of lives for the global pattern of cancer death. However, the percentage of the cancer treatment is too low. Gold nanoparticles have a widely range in terms of biomedical applications in diagnosis, imaging because of their unique optical properties, simple synthesis techniques, biocompatibility and suitable for easy surface change. Redox reactions in the mitochondria generates a potential called as mitochondria membrane potential. The aim of the study is to design mitochondria targeted gold nanorods and to observe how the designed gold nanorods effects the mitochondria membrane potential by targeting the mitochondria on A549 and BEAS-2B cell lines. Gold nanorods were utilized by seed growth mediated method and the surface bioconjugation was performed with triphenyl phosphonium cation as a mitochondria targeted molecule. Poly (sodium-p-styrene sulfonate) was used to prevent aggregation during the bioconjugation process. Gold nanorods which had 30 nm x 10 nm in length and diameter depending on SEM images had well-defined absorption bands 513 nm and 774 nm in wavelength. Mito-pot analysis with the fluorescent intensity ratio and colocalization analysis with light intensity for targeting gold nanorods to mitochondria showed that the accumulation on mitochondria for TPP-GNR was higher than PSSGNR. TPP-GNR was more toxic than PSS-GNR for both of cell lines by investigations of MTT viability test. TPP-GNR targeted to mitochondria and it affected fundamental cellular functions in mitochondria. To concluded that accumulation on mitochondria was accomplished for TPP-GNR and the decreasing of mitochondria membrane potential was observed on this study.
  • Master Thesis
    Developing Mobile, Electronic and Positioning Applications for Emergency Situations Inside the Hospital
    (Izmir Institute of Technology, 2018) Sürmeli, Nur Başak; Sürmeli, Nur Başak; Karabudak, Engin; Karabudak, Engin; Sürmeli, Nur Başak; 04.01. Department of Chemistry; 03.01. Department of Bioengineering; 03. Faculty of Engineering; 04. Faculty of Science; 01. Izmir Institute of Technology
    The aim of this project is to prevent mortality by providing emergency response on time. The communication inside the hospital is provided via developing application for Android and Ios operating system. The content of application is suitable for everyone’s use. The emergency call button makes it easy to call, and if the button is disabled, the heart rate rhythm starts for emergency intervention. This application is associated with bluetooth low energy systems in terms of help to locate the patient. Beacon systems provide data transfer through bluetooth by this means location is detected without internet. The project will be tested primarily at the laboratory following these steps. If it succeeds statistically, the project will be tried at the Tepecik Education and Research Hospital. The success of the project will be reviewed depends on the scenarios in the hospital.