Master Degree / Yüksek Lisans Tezleri

Permanent URI for this collectionhttps://hdl.handle.net/11147/3008

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Subject: search.filters.subject.Methylene blue

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  • Master Thesis
    Methylene Blue (mb) Loaded Zif-8 Synthesis, Characterization and Investigation of Photodynamic Therapy Activity on Breast Cancer
    (01. Izmir Institute of Technology, 2024) Öztürk, Pınar; Mohamed, Gülşah Şanlı; 01. Izmir Institute of Technology
    Günümüzde meme kanserinin teşhis ve tedavisinde çeşitli yöntemler kullanılmasına rağmen, geleneksel yöntemlerin ilaç direnci, ilaç sitotoksisitesi, metastaz ve nüks gibi dezavantajları vardır. Bu nedenle, hastalığın erken teşhisi ve tedavi sürecinin iyileştirilmesi için yeni yöntemler geliştirilmesi gerekmektedir. Fotodinamik tanı ve tedavi, son yıllarda bu bağlamda önem kazanan bir yaklaşımdır. Bu çalışmanın temel amacı, metal-organik iskeleleri ilk kez fotodinamik tedavi ile birlikte metilen mavisinin meme kanseri tedavi sürecine dahil etmek için kullanmaktır. Metilen mavisi kullanılan nano-taşıma sistemi, meme kanseri hücre hatları MDA-MB231 ve MCF-7 üzerindeki sitotoksik etkisi açısından incelenmiştir. ZIF-8'in bozunarak hücrelere çinko sağlaması nedeniyle, bu malzemenin fotodinamik tedaviye ek olarak terapötik bir özellik göstermesi beklenmiştir. Ayrıca, tek bir nanopartikül içerisinde birden fazla sitotoksik bileşenin birleştirilmesi ve bunların kombine etkileri değerlendirilmiştir. Yeni nesil nano taşıyıcılar, metilen mavisini düşük pH'a sahip kanser hücrelerinde spesifik olarak salmak üzere tasarlanmış olup, sağlıklı dokulara zarar vermekten kaçınılarak tedavi sürecinin kalitesinin artırılması hedeflenmiştir
  • Master Thesis
    Methylene Blue Degradation in Water Using Sol-Gel Made Tio2 Supported Oxide Photocatalysts
    (Izmir Institute of Technology, 2011) Köseoğlu, Burcu; Şeker, Erol; Şeker, Erol; 03.02. Department of Chemical Engineering; 03. Faculty of Engineering; 01. Izmir Institute of Technology
    Pure TiO2 and Fe3+ doped TiO2 photocatalysts were synthesized by changing H2O/Ti ratio, HCl/Ti ratios and calcination temperatures. Photocatalytic activities of the samples were determined for the degradation of methylene blue. The primary objective of this study is to narrow the band gap energies of the photocatalysts by changing preparation procedure and also doping with Fe3+ ions. Pure TiO2 and Fe3+ doped TiO2 photocatalysts were prepared by the sol-gel method, and also the impregnation method was applied for Fe3+ doping. The characterization of the samples was performed by using XRD and DRS techniques. Photocatalytic activities were measured by using UVvis absorbance. This study shows that the heat treatment directly affected the crystallite size.Generally, crystallite size of the samples increased with calcination temperature and the heat treatment between 700 C and 800 C also resulted in crystalline phase transformation from anatase to rutile. TiO2 samples prepared with H2O/Ti ratio of 4 and HCl/Ti ratio of 0.15 calcined at 700 C and H2O/Ti ratio of 4 and HCl/Ti ratio of 0.45 calcined at 800 C had only rutile phase. Band gap energy is one of the important factors affecting the photocatalytic activities. In this thesis study, band gap energies of the TiO2 samples were calculated using DR spectrums together with Kubelka Munk function. The DRS analyses showed that samples with rutile phase had the smallest band gap energies; in fact, the pure TiO2 samples (H2O/Ti ratio of 4 and HCl/Ti ratio of 0.45 calcined at 900 C) had the minimum band gap energy of 3.019 eV and the maximum photocatalytic conversion of 25% in 10 min and 93% conversion was reached in 15 h. In contrast, photocatalytic conversion decreased with doping with Fe3+ with excessive dissolution of iron ions.