Veri Setleri / Datasets

Permanent URI for this collectionhttps://hdl.handle.net/11147/10757

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Now showing 1 - 5 of 5
  • Dataset
    MP Questionnaire Form_Responses
    (Aperta, 2025-03-28) Yurt, Canberk
    Blurring Borders of Production and Consumption: The Characterization of the Maker/Prosumer (M/P) Concept - Submitted article, supportive document
  • Dataset
    Appendices of "A Co-Design Workshop as Toy Hacking by Children and Design Students: Collage Toys"
    (Aperta, 2025-06-19) Talu, Nilüfer; Yurt, Canberk
    This is the dataset provided for the manuscript, entitled "A Co-Design Workshop as Toy Hacking by Children and Design Students: Collage Toys". It provides a wide scope of supportive appendices, which consist of raw data and processed data.
  • Dataset
    Research design data set of a co-creation workshop with children
    (Aperta, 2025) Talu, Nilüfer; Yurt, Canberk
    This is the dataset provided for the manuscript, entitled "A Co-Creation Workshop as Toy Hacking by Children and Design Students: Collage Toys". It provides a wide scope of supportive appendices, which consist of raw data and processed data.
  • Dataset
    Knockdown of death receptor 5 antisense long noncoding RNA and cisplatin treatment modulate similar macromolecular and metabolic changes in HeLa cells
    (TÜBİTAK, 2022-12) Gürer, Dilek Cansu; Erdoğan Vatansever, İpek; Ceylan, Çağatay; Akgül, Bünyamin
    Background/aim: Despite great progress in complex gene regulatory mechanisms in the dynamic tumor microenvironment, the potential contribution of long noncoding RNAs (lncRNAs) to cancer cell metabolism is poorly understood. Death receptor 5 antisense (DR5-AS) is a cisplatin inducible lncRNA whose knockdown modulates cell morphology. However, its effect on cell metabolism is unknown. The aim of this study is to examine metabolic changes modulated by cisplatin and DR5-AS lncRNA in HeLa cells. Materials and methods: We used cisplatin as a universal cancer therapeutic drug to modulate metabolic changes in HeLa cervix cancer cells. We then examined the extent of metabolic changes by Fourier transform infrared spectroscopy (FTIR). We also performed transcriptomics analyses by generating new RNA-seq data with total RNAs isolated from cisplatin-treated HeLa cells. Then, we compared cisplatin-mediated transcriptomics and macromolecular changes with those mediated by DR5-AS knockdown. Results: Cisplatin treatment caused changes in the unsaturated fatty acid and lipid-to-protein ratios and the glycogen content. These observations in altered cellular metabolism were supported by transcriptomics analyses. FTIR spectroscopy analyses have revealed that DR5-AS knockdown causes a 20.9% elevation in the lipid/protein ratio and a 76.6% decrease in lipid peroxidation. Furthermore, we detected a 3.42% increase in the chain length of the aliphatic lipids, a higher content of RNA, and a lower amount of glycogen indicating relatively lower metabolic activity in the DR5-AS knockdown HeLa cells. Interestingly, we observed a similar gene expression pattern under cisplatin treatment and DR5-AS knockdown HeLa cells. Conclusion: These results suggest that DR5-AS lncRNA appears to account for a fraction of cisplatin-mediated macromolecular and metabolic changes in HeLa cervix cancer cells. Turkish Journal of Biology dergisine gönderilmiş "Knockdown of death receptor 5 antisense long noncoding RNA and cisplatin treatment modulate similar macromolecular and metabolic changes in HeLa cells" isimli makalenin supplementary data dosyalarını içerir. 117Z243 no'lu TÜBİTAK projesinin yürütücüsü Prof. Dr. Bünyamin AKGÜL'dür.
  • Data Paper
    Database Covering the Previously Excluded Daily Life Activities
    (2023) Mihçin, Şenay; Şahin, Ahmet Mert; Yılmaz, Mehmet; Alpkaya, Alican Tuncay; Tuna, Merve; Can, Nuray Korkmaz; Şahin, Serap; Akdeniz, Sevinç; Tosun, Aliye
    In biomedical engineering, implants are designed according to the boundary conditions of gait data and tested against. However, due to diversity in cultural backgrounds, religious rituals might cause different ranges of motion and different loading patterns. Especially in the Eastern part of the world, diverse Activities of Daily Living (ADL) consist of salat, yoga rituals, and different style sitting postures. Although databases cover ADL for the Western population, a database covering these diverse activities of the Eastern world, specific to these populations is non-existent. To include previously excluded ADL is a key step in understanding the kinematics and kinetics of these activities. By means of developments in motion capture technologies, excluded ADL data are captured to obtain the coordinate values to calculate the range of motion and the joint reaction forces. This study focuses on data collection protocol and the creation of an online database of previously excluded ADL activities, targeting 200 healthy subjects via Qualisys and IMU motion capture systems, and force plates, from West and Middle East Asian populations. Anthropometrics are known to affect kinematics and kinetics which are also included in the collected data. The current version of the database covers 50 volunteers for 12 different activities, the database aims for 100- male and 100- female healthy volunteers as the final target including C3D and BVH file types. The tasks are defined and listed in a table to create a database to make a query based on age, gender, BMI, type of activity and motion capture system. The data is collected only from a healthy population to understand healthy motion patterns during these previously excluded ADLs. The collected data is to be used for designing implants to allow these sorts of activities to be performed without compromising the quality of life of patients performing these activities in the future.