WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

Permanent URI for this collectionhttps://hdl.handle.net/11147/7150

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Access Right: Closed AccessInstitution Author: search.filters.institutionAuthor.Üner, Göklem

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  • Conference Object
    A New Semi-Synthetic Sapogenol Derivative Inducing Regulated Necrosis
    (Georg Thieme Verlag, 2019) Üner, Göklem; Bedir, Erdal; Ballar Kırmızıbayrak, Petek; Üner, Göklem; Bedir, Erdal; 03.01. Department of Bioengineering; 01. Izmir Institute of Technology; 03. Faculty of Engineering
    Since saponin’s antitumor potency is relatively weak, researchers focus on their semi-synthetic modification to obtain structures with higher potencies. With the same motivation, we prepared a cytotoxic sapogenol derivative (AG-08) from cycloastragenol. Our preliminary studies revealed that AG-08 induced primarily necrotic cell death along with autophagic inhibition. Furthermore, immunoblotting experiments demonstrated that AG-08 promoted cleavage of various proteins such as ATGs, p62, and PARP-1.