WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
Permanent URI for this collectionhttps://hdl.handle.net/11147/7150
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Article UV-Shielding Biopolymer Coatings Loaded With Bioactive Compounds for Food Packaging Applications(MDPI, 2025) Gennaro, Matteo; Buyuktas, Duygu; Carullo, Daniele; Pinto, Andrea; Dallavalle, Sabrina; Farris, StefanoFour natural bioactive compounds with UV-absorbing properties-curcumin, quercetin, caffeic acid, and hymecromone-were incorporated into pectin-based coatings deposited on oriented polypropylene (OPP) to develop packaging films with UV-shielding capabilities. The effects of both bioactive compounds (used individually or in combination) and coating thickness (delta = 0.12-1.2 mu m) on the optical properties (UV-Vis transmittance and haze) of the coated OPP samples were investigated. Coating deposition enhanced the UV-barrier properties in relation to the type of bioactive compound, following the order of caffeic acid > hymecromone > curcumin > quercetin. Regardless of the type of bioactive compound used, no significant changes were observed in clarity, haze, and tensile parameters of OPP, whereas the pectin coatings dramatically improved the oxygen barrier performance of the plastic substrate. Additionally, a greater coating thickness resulted in a lower UV-light transmittance of coated PP films. Although the combination of hymecromone and caffeic acid did not exhibit a synergistic effect, it demonstrated an additive benefit, effectively broadening the wavelength range of UV protection in the final packaging materials. While this study highlights that a performance gap remains compared to commercially available UV-shielding materials, it underscores the potential of replacing synthetic UV-absorbing additives with natural compounds through coating technologies rather than masterbatch incorporation.Article Latent Psychological Pathways in Thermal Comfort Perception: the Mediating Role of Cognitive Uncertainty on Depression and Vigour(MDPI, 2025) Ozbey, Mehmet Furkan; Turhan, Cihan; Alkan, Nese; Akkurt, Gulden GokcenThermal comfort is the condition of mind that expresses satisfaction with the thermal environment, and it is assessed through subjective evaluation, according to the American Society of Heating, Refrigerating, and Air-Conditioning Engineers. While research has traditionally emphasised physical factors, growing evidence highlights the role of the state of mind in shaping thermal perception. In a prior Monte Carlo sensitivity analysis, six mood subscales-Anger, Confusion, Vigour, Tension, Depression, and Fatigue-were examined for how they affect the absolute difference between actual and predicted thermal sensation. Depression and vigour were found to be the most influential, while confusion appeared least impactful. However, to accurately assess the role of confusion, it is necessary to consider its potential interactions with other mood subscales. To this end, a mediation analysis was conducted using Hayes' PROCESS tool. The mediation analyses revealed that confusion partially mediated depression's effect in males and vigour's effect in females. These results suggest that, despite a weak direct impact, confusion critically influences thermal perception by altering the effects of key mood states. Accounting for the indirect effects of mood states may lead to more accurate predictions of human sensory experiences and improve the design of occupant-centred environments.Article Subinjectivity Relative To Cotorsion Pairs(MDPI, 2025) Alagoz, Yusuf; Alizade, Rafail; Buyukasik, Engin; Rozas, Juan Ramon Garcia; Oyonarte, LuisIn this paper, we define and study the X-subinjectivity domain of a module M where X=(A,B) is a complete cotorsion pair, which consists of those modules N such that, for every extension K of N with K/N in A, any homomorphism f:N -> M can be extended to a homomorphism g:K -> M. This approach allows us to characterize some classical rings in terms of these domains and generalize some known results. In particular, we classify the rings with X-indigent modules-that is, the modules whose X-subinjectivity domains are as small as possible-for the cotorsion pair X=(FC,FI), where FI is the class of FP-injective modules. Additionally, we determine the rings for which all (simple) right modules are either X-indigent or FP-injective. We further investigate X-indigent Abelian groups in the category of torsion Abelian groups for the well-known example of the flat cotorsion pair X=(FL,EC), where FL is the class of flat modules.Article Citation - WoS: 1Citation - Scopus: 1A Pragmatic Grouping Model for Bone-Only De Novo Metastatic Breast Cancer (MetS Protocol MF22-03)(MDPI, 2025) Goktepe, Berk; Demirors, Berkay; Senol, Kazim; Ozbas, Serdar; Sezgin, Efe; Lucci, Anthony; Soran, AtillaDe novo metastatic breast cancer (dnMBC) accounts for 3-10% of newly diagnosed cases, with 20-40% presenting as a bone-only metastatic disease, which can achieve survival outcomes exceeding 10 years with multimodal therapy. However, the role of multimodal therapy remains controversial in the guidelines. Objective: This study aims to identify dnBOMBC subgroups to develop a pragmatic staging system for guiding locoregional therapy decisions. Materials and Methods: Data from the MF07-01 phase III randomized trial (2021, median follow-up time (mFT): 40 months (range 1-131)) and the BOMET prospective multi-institutional registry trial (2021, mFT: 34 months (range 25-45)) were combined for analysis, including only patients who presented with bone-only metastases. Exclusion criteria were patients under 18 and those with a history of prior cancer or cancer metastases. Patients with missing data and positive surgical margins were excluded. Out of 770 patients, 589 were included. Survival analyses were first conducted according to molecular subgroups, after which patients were further stratified by hormone receptor status, human epidermal human epidermal growth factor receptor 2 (HER2) status, tumor grade, and clinical T (cT) stage. Group A (GrA) included hormone receptor (HR)-positive, low- or intermediate-grade tumors at any cT; HR-positive, high-grade tumors with cT0-3; or any HER2-positive tumors. Group B (GrB) included HR-positive, high-grade tumors with cT4 disease or any triple-negative (TN) tumors. Results: The hazard of death (HoD) was 43% lower in GrA than in GrB. Median OS was 65 months (39-104) for GrA patients and 44 months (28-72) for GrB patients (HR 0.57, 95% CI 0.41-0.78, p = 0.0003). Primary tumor surgery (PTS) significantly improved OS in GrA patients, regardless of the number of metastases (solitary: HR, 0.375, 95% CI 0.259-0.543, p < 0.001; multiple: HR 0.435, 95% CI 0.334-0.615, p < 0.001). Conversely, GrB patients did not experience a significant benefit from PTS. Conclusions: This study demonstrates that GrA patients have better OS than GrB patients, and PTS reduces the HoD in GrA patients compared to systemic therapy alone. These findings support using a modified staging system in dnBOBMC to identify patients who may benefit from multimodal therapy including PTS.Article Citation - WoS: 1Citation - Scopus: 1Tracing the Values of Fading Rural Architectural Heritage: the Case of Cold-Water Baths in Western Anatolia(MDPI, 2025) Guler, Selen; Ustuk, Ozan; Yuceer, HulyaThis research explores the underappreciated traditional cold-water baths of Western Anatolia, once integral to the region's agrarian culture. Due to waves of change, which had markedly begun by the pandemic in 2019 and the aftermath of the 2020 Samos earthquake, there has been a growing interest in living in peri-urban areas, resulting in the invasion of agricultural grounds by new construction, mainly including detached houses with gardens. Such a harsh growth not only threatens the fertile lands, but also the irreplaceable cultural heritage they embrace. In this regional frame, this study focuses on three surviving baths within the Karaburun Peninsula, casting light on their current precarious state as relics of a diminishing rural way of life and local heritage. The traditional cold-water baths, constructed amidst agricultural fields for seasonal use in select villages throughout & Idot;zmir, stand as unique exemplars of rural architecture. Characterised by their singular domed chambers and their reliance on water from adjacent wells, these structures today face abandonment and disrepair. Through a multi-disciplinary lens blending ethnography, oral history, and spatial analysis, this paper portrays these unassuming yet culturally impactful baths, elucidating their intrinsic value within the heritage domain. The inquiry contributes significantly to the heritage conservation discussion, highlighting the broad spectrum of values beyond mere historical interest. By articulating the symbiotic relationship between heritage and its community, this research underscores the pressing need to weave these baths into the fabric of current social structures, safeguarding their place within the collective memory.Article Citation - WoS: 1Citation - Scopus: 1Calcium Indicators With Fluorescence Lifetime-Based Signal Readout: a Structure-Function Study(MDPI, 2024) Simonyan, Tatiana R.; Varfolomeeva, Larisa A.; Mamontova, Anastasia V.; Kotlobay, Alexey A.; Gorokhovatsky, Andrey Y.; Bogdanov, Alexey M.; Boyko, Konstantin M.The calcium cation is a crucial signaling molecule involved in numerous cellular pathways. Beyond its role as a messenger or modulator in intracellular cascades, calcium's function in excitable cells, including nerve impulse transmission, is remarkable. The central role of calcium in nervous activity has driven the rapid development of fluorescent techniques for monitoring this cation in living cells. Specifically, genetically encoded calcium indicators (GECIs) are the most in-demand molecular tools in their class. In this work, we address two issues of calcium imaging by designing indicators based on the successful GCaMP6 backbone and the fluorescent protein BrUSLEE. The first indicator variant (GCaMP6s-BrUS), with a reduced, calcium-insensitive fluorescence lifetime, has potential in monitoring calcium dynamics with a high temporal resolution in combination with advanced microscopy techniques, such as light beads microscopy, where the fluorescence lifetime limits acquisition speed. Conversely, the second variant (GCaMP6s-BrUS-145), with a flexible, calcium-sensitive fluorescence lifetime, is relevant for static measurements, particularly for determining absolute calcium concentration values using fluorescence lifetime imaging microscopy (FLIM). To identify the structural determinants of calcium sensitivity in these indicator variants, we determine their spatial structures. A comparative structural analysis allowed the optimization of the GCaMP6s-BrUS construct, resulting in an indicator variant combining calcium-sensitive behavior in the time domain and enhanced molecular brightness. Our data may serve as a starting point for further engineering efforts towards improved GECI variants with fine-tuned fluorescence lifetimes.