WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
Permanent URI for this collectionhttps://hdl.handle.net/11147/7150
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Article Citation - WoS: 1Citation - Scopus: 2First Measurement of the Forward Rapidity Gap Distribution in Ppb Collisions at √snn=8.16 Tev(Amer Physical Soc, 2023) Karapınar, Güler; CMS Collaboration; Ambrogi, F.; Bergauer, T.; Dragicevic, M.; Ero, J.; Zhokin, A.For the first time at LHC energies, the forward rapidity gap spectra from proton-lead collisions for both proton and lead dissociation processes are presented. The analysis is performed over 10.4 units of pseudorapidity at a center-of-mass energy per nucleon pair of ffisffi than in previous measurements of diffractive production in proton-nucleus collisions. For lead dissociation processes, which correspond to the pomeron-lead event topology, the EPOS-LHC generator predictions are a factor of 2 below the data, but the model gives a reasonable description of the rapidity gap spectrum shape. For the pomeron-proton topology, the EPOS-LHC, QGSJET II, and HIJING predictions are all at least a factor of 5 lower than the data. The latter effect might be explained by a significant contribution of ultraperipheral photoproduction events mimicking the signature of diffractive processes. These data may be of significant help in understanding the high energy limit of quantum chromodynamics and for modeling cosmic ray air showers.Article Citation - WoS: 6Citation - Scopus: 5Gelatin-Containing Porous Polycaprolactone Polyhipes as Substrates for 3d Breast Cancer Cell Culture and Vascular Infiltration(Frontiers Media Sa, 2024) Jackson, Caitlin E.; Doyle, Iona; Khan, Hamood; Williams, Samuel F.; Dikici, Betul Aldemir; Ledesma, Edgar Barajas; Claeyssens, FrederikTumour survival and growth are reliant on angiogenesis, the formation of new blood vessels, to facilitate nutrient and waste exchange and, importantly, provide a route for metastasis from a primary to a secondary site. Whilst current models can ensure the transport and exchange of nutrients and waste via diffusion over distances greater than 200 mu m, many lack sufficient vasculature capable of recapitulating the tumour microenvironment and, thus, metastasis. In this study, we utilise gelatin-containing polymerised high internal phase emulsion (polyHIPE) templated polycaprolactone-methacrylate (PCL-M) scaffolds to fabricate a composite material to support the 3D culture of MDA-MB-231 breast cancer cells and vascular ingrowth. Firstly, we investigated the effect of gelatin within the scaffolds on the mechanical and chemical properties using compression testing and FTIR spectroscopy, respectively. Initial in vitro assessment of cell metabolic activity and vascular endothelial growth factor expression demonstrated that gelatin-containing PCL-M polyHIPEs are capable of supporting 3D breast cancer cell growth. We then utilised the chick chorioallantoic membrane (CAM) assay to assess the angiogenic potential of cell-seeded gelatin-containing PCL-M polyHIPEs, and vascular ingrowth within cell-seeded, surfactant and gelatin-containing scaffolds was investigated via histological staining. Overall, our study proposes a promising composite material to fabricate a substrate to support the 3D culture of cancer cells and vascular ingrowth.Review Citation - WoS: 5Scientists Without Borders: Lessons From Ukraine [2](Oxford Univ Press, 2023) Wolfsberger, Walter; Chhugani, Karishma; Shchubelka, Khrystyna; Frolova, Alina; Salyha, Yuriy; Zlenko, Oksana; Arych, MykhailoConflicts and natural disasters affect entire populations of the countries involved and, in addition to the thousands of lives destroyed, have a substantial negative impact on the scientific advances these countries provide. The unprovoked invasion of Ukraine by Russia, the devastating earthquake in Turkey and Syria, and the ongoing conflicts in the Middle East are just a few examples. Millions of people have been killed or displaced, their futures uncertain. These events have resulted in extensive infrastructure collapse, with loss of electricity, transportation, and access to services. Schools, universities, and research centers have been destroyed along with decades' worth of data, samples, and findings. Scholars in disaster areas face short- and long-term problems in terms of what they can accomplish now for obtaining grants and for employment in the long run. In our interconnected world, conflicts and disasters are no longer a local problem but have wide-ranging impacts on the entire world, both now and in the future. Here, we focus on the current and ongoing impact of war on the scientific community within Ukraine and from this draw lessons that can be applied to all affected countries where scientists at risk are facing hardship. We present and classify examples of effective and feasible mechanisms used to support researchers in countries facing hardship and discuss how these can be implemented with help from the international scientific community and what more is desperately needed. Reaching out, providing accessible training opportunities, and developing collaborations should increase inclusion and connectivity, support scientific advancements within affected communities, and expedite postwar and disaster recovery.Article Iron-Promoted 1,5-Substitution Reaction of Endocyclic Enyne Oxiranes With Memgbr: a Stereoselective Method for the Synthesis of Exocyclic 2,4,5-Trienol Derivatives(MDPI, 2023) Kuş, Melih; Omur, Cenk; Karaca, Sila; Artok, LeventThe iron-promoted 1,5-substitution reaction of endocyclic oxiranes with MeMgBr yields exocyclic 2,4,5-trienols with high diastereomeric ratios of up to 100:0. However, for the method's success, the oxirane ring must have a trans-configuration. The reactions exhibit strong stereoselectivity concerning the methylation mode and the configuration of the resulting exocyclic double bond. Enantiomerically pure enyne oxiranes can be synthesized through Sharpless asymmetric dihydroxylation and subsequent manipulations. With these reagents, it has been possible to produce exocyclic 2,4,5-trienols in enantiopure forms. Importantly, this process maintains chirality without degradation during the center-to-axis transfer of chirality.Article Citation - WoS: 1Citation - Scopus: 1Light-Dark and Activity Rhythm Therapy (l-Dart) To Improve Sleep in People With Schizophrenia Spectrum Disorders: a Single-Group Mixed Methods Study of Feasibility, Acceptability and Adherence(MDPI, 2023) Faulkner, Sophie; Didikoğlu, Altuğ; Byrne, Rory; Drake, Richard; Bee, PennyPeople with a diagnosis of schizophrenia often have poor sleep, even when their psychotic symptoms are relatively well managed. This includes insomnia, sleep apnoea, hypersomnia, and irregular or non-24 h sleep-wake timing. Improving sleep would better support recovery, yet few evidence-based sleep treatments are offered to this group. This paper presents a mixed methods feasibility and acceptability study of Light-Dark and Activity Rhythm Therapy (L-DART). L-DART is delivered by an occupational therapist over 12 weeks. It is highly personalisable to sleep phenotypes and circumstances. Ten participants with schizophrenia spectrum diagnoses and sleep problems received L-DART; their sleep problems and therapy goals were diverse. We measured recruitment, attrition, session attendance, and adverse effects, and qualitatively explored acceptability, engagement, component delivery, adherence, activity patterns, dynamic light exposure, self-reported sleep, wellbeing, and functioning. Recruitment was ahead of target, there was no attrition, and all participants received the minimum 'dose' of sessions. Acceptability assessed via qualitative reports and satisfaction ratings was good. Adherence to individual intervention components varied, despite high participant motivation. All made some potentially helpful behaviour changes. Positive sleep and functioning outcomes were reported qualitatively as well as in outcome measures. The findings above support testing the intervention in a larger randomised trial ISRCTN11998005.Article Influence of Microstructure and Crystallographic Texture on Hydrogen Diffusion in If-Steel(Technical Faculty, Bor-serbia, 2023) Baskaya, U.; Uzun, R.; Davut, K.; Kilic, Y.; Gunduz, O.The relation between microstructure, crystallographic texture, and hydrogen diffusion was studied on a IF-steel. The steel samples were deep drawn to a strain level of 10%, 20%, 30% and 40% and then the hydrogen diffusion coefficients were determined using the Helios II system. Light optical microscope (LOM), scanning electron microscope (SEM) and electron backscatter diffraction (EBSD) were used for microstructural characterization and crystallographic texture studies. The dependence of microstructural parameters was evaluated by Pearson correlation coefficient (PCC) values. These evaluations showed that local misorientations, crystallographic texture, and dislocation densityare interdependent. The PCC values show that grain size and dislocation density are the independent microstructure related parameters. These parameters were used to build a model to predict the hydrogen diffusion coefficient by multiple linear regression analysis. A sensitivity analysis was also performed with this model to understand to which parameter the hydrogen diffusion is most sensitive. The results of this analysis show that hydrogen diffusion is more sensitive to dislocation density, suggesting that dislocations are more effective trapping sites for hydrogen atoms. On the other hand, grain boundaries are less effective trapping sites since they also provide an additional diffusion mechanism.Article Citation - WoS: 2Citation - Scopus: 14Combination of Inclusive Top-Quark Pair Production Cross-Section Measurements Using Atlas and Cms Data at S = 7 and 8 Tev(Springer Science and Business Media Deutschland GmbH, 2023) Aad,G.; Abbott,B.; Abbott,D.C.; Abed Abud,A.; Abeling,K.; Abhayasinghe,D.K.; Jiggins,S.A combination of measurements of the inclusive top-quark pair production cross-section performed by ATLAS and CMS in proton–proton collisions at centre-of-mass energies of 7 and 8 TeV at the LHC is presented. The cross-sections are obtained using top-quark pair decays with an opposite-charge electron–muon pair in the final state and with data corresponding to an integrated luminosity of about 5 fb−1 at s = 7 TeV and about 20 fb−1 at s = 8 TeV for each experiment. The combined cross-sections are determined to be 178.5 ± 4.7 pb at s = 7 TeV and 243.3−5.9+6.0 pb at s = 8 TeV with a correlation of 0.41, using a reference top-quark mass value of 172.5 GeV. The ratio of the combined cross-sections is determined to be R8/7 = 1.363 ± 0.032. The combined measured cross-sections and their ratio agree well with theory calculations using several parton distribution function (PDF) sets. The values of the top-quark pole mass (with the strong coupling fixed at 0.118) and the strong coupling (with the top-quark pole mass fixed at 172.5 GeV) are extracted from the combined results by fitting a next-to-next-to-leading-order plus next-to-next-to-leading-log QCD prediction to the measurements. Using a version of the NNPDF3.1 PDF set containing no top-quark measurements, the results obtained are mtpole=173.4−2.0+1.8 GeV and αsmZ=0.1170−0.0018+0.0021. © The Author(s) 2023.Review Citation - WoS: 13Citation - Scopus: 13Oxygen Delivery Biomaterials in Wound Healing Applications(WILEY-V C H VERLAG GMBH, 2023) Bayraktar, Sema; Üstün, Cansu; Kehr, Nermin SedaOxygen (O2) delivery biomaterials have attracted great interest in the treatment of chronic wounds due to their potential applications in local and continuous O2 generation and delivery, improving cell viability until vascularization occurs, promoting structural growth of new blood vessels, simulating collagen synthesis, killing bacteria and reducing hypoxia-induced tissue damage. Therefore, different types of O2 delivery biomaterials including thin polymer films, fibers, hydrogels, or nanocomposite hydrogels have been developed to provide controlled, sufficient and long-lasting O2 to prevent hypoxia and maintain cell viability until the engineered tissue is vascularized by the host system. These biomaterials are made by various approaches, such as encapsulating O2 releasing molecules into hydrogels, polymer microspheres and 3D printed hydrogel scaffolds and adsorbing O2 carrying reagents into polymer films of fibers. In this article, different O2 generating sources such as solid inorganic peroxides, liquid peroxides, and photosynthetic microalgae, and O2 carrying perfluorocarbons and hemoglobin are presented and the applications of O2 delivery biomaterials in promoting wound healing are discussed. Furthermore, challenges encountered and future perspectives are highlighted. Oxygen delivery (O2) biomaterials have attracted great interest in the treatment of chronic wounds due to their ability to continuously deliver oxygen and support cell viability. Therefore, various O2 generating sources such as solid inorganic peroxides, liquid peroxides and photosynthetic microalgae, and O2-carrying perfluorocarbons and hemoglobin are incorporated into different biomaterial networks for wound healing applications.imageArticle Citation - WoS: 8Citation - Scopus: 8Urban Earthquake Vulnerability Assessment and Mapping at the Microscale Based on the Catastrophe Progression Method(SPRINGER, 2023) Gerçek, Deniz; Güven, İsmail TalihVulnerability assessment and mapping play a crucial role in disaster risk reduction and planning for adaptation to a future earthquake. Turkey is one of the most at-risk countries for earthquake disasters worldwide. Therefore, it is imperative to develop effective earthquake vulnerability assessment and mapping at practically relevant scales. In this study, a holistic earthquake vulnerability index that addresses the multidimensional nature of earthquake vulnerability was constructed. With the aim of representing the vulnerability as a continuum across space, buildings were set as the smallest unit of analysis. The study area is in Izmit City of Turkey, with the exposed human and structural elements falling inside the most hazardous zone of seismicity. The index was represented by the building vulnerability, socioeconomic vulnerability, and vulnerability of the built environment. To minimize the subjectivity and uncertainty that the vulnerability indices based on expert knowledge are suffering from, an extension of the catastrophe progression method for the objective weighing of indicators was proposed. Earthquake vulnerability index and components were mapped, a local spatial autocorrelation metric was employed where the hotspot maps demarcated the earthquake vulnerability, and the study quantitatively revealed an estimate of people at risk. With its objectivity and straightforward implementation, the method can aid decision support for disaster risk reduction and emergency management.Article Citation - WoS: 11Citation - Scopus: 11A Comprehensive Characterization of the Effect of Spatter Powder on In939 Parts Fabricated by Laser Powder Bed Fusion(ELSEVIER SCI LTD, 2023) Dogu, Merve Nur; Mussatto, Andre; Yalçın, Mustafa Alp; Özer, Seren; Davut, Kemal; Obeidi, Muhannad Ahmed; Kumar, AjayThis study is focused on a comprehensive characterization of virgin and spatter IN939 powders and the effects of a certain amount of spatter powder on the part quality of IN939 fabricated by the L-PBF process. A brown tint coloration formed Al2O3 oxide, pores, a 124.4% increase in the average particle size, a 10.2% decrease in the powder circularity, and a 7.5% decrease in the powder aspect ratio were observed in the spatter powder. Additionally, higher average grain size and lower nanohardness were obtained for the spatter powder. In order to understand the effect of a certain amount of spatter powder on the part quality, 10 wt% spatter powder was mixed with the virgin powder. This addition was found to decrease the flowability of the powder. Moreover, this addition decreased relative density by around 0.3% and increased surface roughness by around 80.8% in the fabricated samples (termed as V and SV). On the other hand, there was no considerable microstructural, texture, microhardness, and nanohardness difference between V and SV samples, although the spatter powder addition caused a 30.2% increase in the average grain size of SV. The overall texture for both V and SV samples exhibit (00 1)//BD.