WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
Permanent URI for this collectionhttps://hdl.handle.net/11147/7150
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Article Design, Synthesis, and Biological Evaluation of Novel Water-Soluble Quinoline-Based Conjugates with Antioxidant, Antimicrobial, and DNA-Binding Activities(Society of Chemists and Technologists Madeconia, 2025) Emrullahoğlu, Mustafa; Okumus, Veysi; Emrullahoglu, Mustafa; Gumus, Selcuk; 04.04. Department of Photonics; 04. Faculty of Science; 01. Izmir Institute of TechnologyConsidering the extremely valuable biological and pharmaceutical properties of quinolines, novel water-soluble quinoline-based conjugates were designed and synthesized. In vitro antioxidant activities, such as free radical scavenging, metal chelating, and reducing-power activities, of the newly synthesized compounds (WQ-1, WQ-2, WQ-3, WQ-4, and WQ-5) were determined. Although the highest scavenging activity (41.21 +/- 1.18%) and chelating activity (23.53 +/- 0.97%) at a concentration of 500.0 mu g/ml were observed in WQ-4, it was determined that WQ-5 had the highest reducing-power ability (0.417 +/- 0.0116). The synthesized compounds were also tested for their antimicrobial activities against two Grampositive and two Gram-negative bacteria, and it was determined that only WQ-3 showed low activity against Enterococcus hirae and Staphylococcus aureus. DNA-binding activities of the compounds were also studied using calf thymus DNA (CT-DNA). Additionally, the three-dimensional geometries and some electronic properties of the synthesized compounds were investigated with the density functional theory approach at B3LYP/6-31++G(d,p) level of theory.Article Homogeneity Enhancement of Oxide Additives in Boron Carbide by Precipitation Method(University of Novi Sad, Faculty of Technology, 2025) Toksoy, Muhammet Fatih; Elçi, C.; 01. Izmir Institute of Technology; 03.10. Department of Mechanical Engineering; 03. Faculty of EngineeringThis study elucidates the use of the precipitation method to enhance the uniformity of oxide additives in boron carbide ceramics. Achieving a homogeneous distribution of additives is critical, as higher additive content tends to degrade the mechanical properties of boron carbide. In this research, yttrium and aluminium hydroxide salts were dispersed and incorporated into boron carbide slurry under highly alkaline conditions. The mixture was aged and subsequently calcined to produce metal oxide layers around the boron carbide particles. The additive-to-boron carbide ratio and calcination conditions were systematically varied and the resulting powders were characterized using SEM, EDX and zeta potential analyses. The precipitation method effectively improved additive dispersion, achieving a uniform distribution. Furthermore, samples processed through precipitation exhibited higher densities compared to conventional benchmark samples. © 2025 University of Novi Sad, Faculty of Technology. All rights reserved.Article Citation - WoS: 45Citation - Scopus: 57Analytical Synthesis of Function Generating Spherical Four-Bar Mechanism for the Five Precision Points(Elsevier Ltd., 2005) Alizade, Rasim I.; Alizade, Rasim; Kilit, Özgür; 03.10. Department of Mechanical Engineering; 03. Faculty of Engineering; 01. Izmir Institute of TechnologyThis paper presents an analytical method for synthesis of function generating spherical 4R mechanisms for the five precision points. For the design requirements an additional parameter, reference value of output angle, ψ0, was added to angular link length parameters, α i(i = 1, ..., 4). In the dimensional synthesis procedure, a novel approach of polynomial approximation method was proposed to determine these five design parameters. Using this method, a set of five non-linear equations was easily transformed into a set of fifteen linear equations. Hence, the problem was reduced to the solution of a cubic polynomial equation. Moreover, a graphical method in a CAD environment is proposed to verify the solutions. © 2005 Elsevier Ltd. All rights reserved.