WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

Permanent URI for this collectionhttps://hdl.handle.net/11147/7150

Browse

Filters

20252

Settings

Access type: Metadata onlyAuthor: search.filters.author.Ardicli, Sena

Search Results

Now showing 1 - 2 of 2
  • Article
    Influence of SCD and FABP3 Genetic Markers on Carcass Traits and Meat Quality in Aberdeen Angus Bulls
    (Revista Brasileira Zootecnia Brazilian Journal Animal Sci, 2025) Ardicli, Sena; Senturk, Nursen; Selvi, Tugce Necla; Yonga, Sena; Celik, Rumeysa; Karalar, Beyza; Ustuner, Hakan
    This study evaluated the association of stearoyl-CoA desaturase (SCD) and fatty acid-binding protein 3 (FABP3) gene polymorphisms with carcass and meat quality traits in Aberdeen Angus bulls. Two hundred seventy-four Angus bulls were genotyped using PCR-RFLP and Sanger sequencing. Next, the association of SCD and FABP3 genetic variants with traits such as live weight, average daily weight gain, carcass weight (both hot and cold), dressing percentage, carcass length, back fat thickness, carcass color score, pH, and marbling score was analyzed. Significant differences were observed in average daily weight gain among different FABP3 genotypes, with the GG genotype showing the highest gains (P<0.01). Furthermore, novel associations between the SCD x FABP3 interaction and key traits were identified, including dressing percentage and carcass pH. Notably, an epistatic pattern through this genotypic interaction was demonstrated, which may significantly influence postmortem pH decline in beef cattle. The results suggest a notable impact of the FABP3 rs210042291 gene on growth rates. These findings highlight the complexity of genetic influences on meat quality traits.
  • Article
    The Effectiveness of Genetic Markers and the Role of Environmental Factors in Hip Dysplasia and Osteochondritis Dissecans of the Shoulder in German Shepherd, Labrador Retriever, and German Wirehaired Pointer (Deutsch Drahthaar) Dogs
    (Elsevier, 2025) Ardicli, Sena; Yigitgor, Pelin; Ozen, Dogukan; Babayev, Huseyn; Bozkurt, Berkay; Senturk, Nursen; Intas, Deniz Seyrek
    Canine Hip Dysplasia (CHD) is the most frequently diagnosed orthopedic condition in dogs. Similar to CHD, osteochondritis dissecans (OCD) of the shoulder is a developmental disorder in dogs that significantly impacts animal welfare. As polygenic genetic disorders, they exhibit a complex mode of inheritance. Although there are numerous clinical studies, there is insufficient information about the genetic basis of these disorders. Therefore, this study aimed to assess the relationship of the prognostic genetic test markers with CHD and OCD in German Shepherd, Labrador Retriever, and German Wirehaired Pointer dogs. We evaluated the efficiency of five SNP markers from the prognostic genetic test for CHD (the Dysgen test) based on available GWAS data in German Shepherd, Labrador Retriever, and German Wirehaired Pointer dogs. Radiographs were captured and assessed according to the official FCI scale for hip dysplasia. In German Wirehaired Pointers, shoulder X-ray evaluations were also performed. We used custom FRET-based primer probes in Real-time PCR and Sanger sequencing for genotyping and tested the evaluation using multiple logistic regression procedures. German shepherds emerged as the most vulnerable to CHD (P < 0.001). In the final logistic model, females are expected to have a 3.54 times higher likelihood of experiencing CHD compared to males (P < 0.05). SNP BICF2G630558239 demonstrated a notable association with CHD, indicating that the GG genotype poses a risk. This SNP is situated in the intronic region of the KIF26B gene, a member of the kinesin superfamily implicated in evolutionarily conserved roles in embryogenesis. We did not observe any association between shoulder OCD-related arthrosis and the SNPs studied. These results may contribute to understanding CHD by identifying genotypes associated with epidemiological risk, prompting the need to conduct more thorough investigations.