WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

Permanent URI for this collectionhttps://hdl.handle.net/11147/7150

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  • Article
    Design, Synthesis, and Biological Evaluation of Novel Water-Soluble Quinoline-Based Conjugates with Antioxidant, Antimicrobial, and DNA-Binding Activities
    (Society of Chemists and Technologists Madeconia, 2025) Emrullahoğlu, Mustafa; Okumus, Veysi; Emrullahoglu, Mustafa; Gumus, Selcuk; 04.04. Department of Photonics; 04. Faculty of Science; 01. Izmir Institute of Technology
    Considering the extremely valuable biological and pharmaceutical properties of quinolines, novel water-soluble quinoline-based conjugates were designed and synthesized. In vitro antioxidant activities, such as free radical scavenging, metal chelating, and reducing-power activities, of the newly synthesized compounds (WQ-1, WQ-2, WQ-3, WQ-4, and WQ-5) were determined. Although the highest scavenging activity (41.21 +/- 1.18%) and chelating activity (23.53 +/- 0.97%) at a concentration of 500.0 mu g/ml were observed in WQ-4, it was determined that WQ-5 had the highest reducing-power ability (0.417 +/- 0.0116). The synthesized compounds were also tested for their antimicrobial activities against two Grampositive and two Gram-negative bacteria, and it was determined that only WQ-3 showed low activity against Enterococcus hirae and Staphylococcus aureus. DNA-binding activities of the compounds were also studied using calf thymus DNA (CT-DNA). Additionally, the three-dimensional geometries and some electronic properties of the synthesized compounds were investigated with the density functional theory approach at B3LYP/6-31++G(d,p) level of theory.
  • Article
    Homogeneity Enhancement of Oxide Additives in Boron Carbide by Precipitation Method
    (University of Novi Sad, Faculty of Technology, 2025) Toksoy, Muhammet Fatih; Elçi, C.; 01. Izmir Institute of Technology; 03.10. Department of Mechanical Engineering; 03. Faculty of Engineering
    This study elucidates the use of the precipitation method to enhance the uniformity of oxide additives in boron carbide ceramics. Achieving a homogeneous distribution of additives is critical, as higher additive content tends to degrade the mechanical properties of boron carbide. In this research, yttrium and aluminium hydroxide salts were dispersed and incorporated into boron carbide slurry under highly alkaline conditions. The mixture was aged and subsequently calcined to produce metal oxide layers around the boron carbide particles. The additive-to-boron carbide ratio and calcination conditions were systematically varied and the resulting powders were characterized using SEM, EDX and zeta potential analyses. The precipitation method effectively improved additive dispersion, achieving a uniform distribution. Furthermore, samples processed through precipitation exhibited higher densities compared to conventional benchmark samples. © 2025 University of Novi Sad, Faculty of Technology. All rights reserved.