WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
Permanent URI for this collectionhttps://hdl.handle.net/11147/7150
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Article Influence of SCD and FABP3 Genetic Markers on Carcass Traits and Meat Quality in Aberdeen Angus Bulls(Revista Brasileira Zootecnia Brazilian Journal Animal Sci, 2025) Ardicli, Sena; Senturk, Nursen; Selvi, Tugce Necla; Yonga, Sena; Celik, Rumeysa; Karalar, Beyza; Ustuner, HakanThis study evaluated the association of stearoyl-CoA desaturase (SCD) and fatty acid-binding protein 3 (FABP3) gene polymorphisms with carcass and meat quality traits in Aberdeen Angus bulls. Two hundred seventy-four Angus bulls were genotyped using PCR-RFLP and Sanger sequencing. Next, the association of SCD and FABP3 genetic variants with traits such as live weight, average daily weight gain, carcass weight (both hot and cold), dressing percentage, carcass length, back fat thickness, carcass color score, pH, and marbling score was analyzed. Significant differences were observed in average daily weight gain among different FABP3 genotypes, with the GG genotype showing the highest gains (P<0.01). Furthermore, novel associations between the SCD x FABP3 interaction and key traits were identified, including dressing percentage and carcass pH. Notably, an epistatic pattern through this genotypic interaction was demonstrated, which may significantly influence postmortem pH decline in beef cattle. The results suggest a notable impact of the FABP3 rs210042291 gene on growth rates. These findings highlight the complexity of genetic influences on meat quality traits.Article Citation - WoS: 2Citation - Scopus: 2The Markers of the Predictive Dna Test for Canine Hip Dysplasia May Have a Stronger Relationship With Elbow Dysplasia(Cell Press, 2024) Ardicli, Sena; Yigitgor, Pelin; Babayev, Huseyn; Ozen, Dogukan; Bozkurt, Berkay; Senturk, Nursen; Intas, Deniz SeyrekCanine hip and elbow dysplasias, which are prevalent orthopedic conditions rooted in developmental and hereditary factors are yet to be comprehensively assessed. This study aimed to address this gap by exploring the prognostic significance of five markers linked to canine hip dysplasia using available genome-wide association studies (GWAS) data. The influence of these markers on both hip and elbow dysplasia was examined in dogs exposed to standardized environmental conditions. We made a groundbreaking discovery using custom primers, qPCR assays, and evaluation of fluorescent resonance energy transfer (FRET) probes. Three specific SNPs previously associated with the risk of canine hip dysplasia demonstrated a potentially stronger correlation with elbow dysplasia. Notably, the SNP at nucleotide position 22691322, located near the canine CHST3 gene, displayed significance as a marker in multivariable logistic regression analysis. Surprisingly, none of the initially targeted SNPs showed a direct association with hip dysplasia. The genomic positions of these SNPs reside within a region conserved across mammals. In silico analyses suggested that the relevant variant might be positioned in a region linked to bone and muscle structures. Our findings revealed a remarkable relationship between SNP2 genotypes and methylation patterns, shedding light on the underlying mechanism that partially explains the genotype-phenotype correlation in canine CHST3. These groundbreaking findings offer essential insights for future, more extensive investigations into canine orthopedic health. This research significantly contributes to our understanding of the molecular foundations of hip and elbow dysplasia in dogs by charting a course for advancements in veterinary medicine and the overall well-being of canine companions.