WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
Permanent URI for this collectionhttps://hdl.handle.net/11147/7150
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Article Citation - WoS: 1Citation - Scopus: 1Plasma-Enhanced Cvd Synthesis and Cytotoxic Evaluation of Graphitic Carbon Embedded – Fe3O4 Nanoparticles(Elsevier Sci Ltd, 2025) Balci-Cagiran, Ozge; Mertdinc-Ulkuseven, Siddika; Solati, Navid; Onbasli, Kubra; Yagci-Acar, Havva; Agaogullari, Duygu; 01. Izmir Institute of TechnologyThis study reports the synthesis of graphitic carbon embedded - Fe3O4 nanoparticles using a novel method that enables a low-temperature rapid process and includes cytotoxicity tests to evaluate their potential use in biomedical applications. In this study, graphitic carbon was grown on Fe3O4 core using a plasma-enhanced chemical vapor deposition (PE-CVD) system under an Ar-H-2-CH4 gas plasma at 650 degrees C for 15 min. X-ray diffractometry (XRD) and Raman spectroscopy investigations confirmed that Fe3O4 nanoparticles were embedded in graphitic carbon (Fe3O4@C). Scanning electron microscopy (SEM) and energy-dispersive X-ray spectroscopy (EDS), along with transmission electron microscopy (TEM) equipped with EDS, also supported the carbon formation and nano-sized structure of the synthesized particles. Fe3O4@C nanoparticles exhibited soft magnetic properties with saturation magnetization (M-s) and coercivity (H-c) values of 69.27 emu/g and 97 Oe, respectively. Cytotoxicity assessment on HeLa and MCF7 cancer cells suggested biocompatibility at and below a dose of 100 mu g/mL after 24 h of exposure but a drop in cell viability at higher doses and longer incubation times, more on cancer cell lines than the healthy L929 cells. These results suggest that Fe3O4@C nanoparticles might be potential candidates for biomedical applications, including drug delivery, photothermal therapy, and magnetically-triggered operations.Article Citation - WoS: 2Citation - Scopus: 2Synthesis of Oleic Acid - Coated Zinc - Doped Iron Boride Nanoparticles for Biomedical Applications(Elsevier Sci Ltd, 2024) Çağıran, Özge Balcı; Aydemir, Duygu; Somer, Mehmet; Ulusu, Nuriye Nuray; Balci-Cagiran, Ozge; 01. Izmir Institute of Technology; 03.09. Department of Materials Science and Engineering; 03. Faculty of EngineeringAlthough various iron-based magnetic materials have been extensively studied in biomedical field for many years, iron boride compounds with interesting chemical and magnetic properties are relatively less explored, and their potential applications are not as widely known. In this study, the synthesis, coating, surface modification, and cytotoxicity tests of the Fe-Zn-B system were presented. Iron boride-based nanoparticles (NPs) containing elemental zinc (Zn) were developed by using a direct chemical synthesis of FeCl3, 3 , ZnCl2 2 and NaBH4, 4 , and investigated for potential use in biomedical applications. Powders having the phases of pure FeB with small amount of elemental Zn were obtained with a uniform morphology and an average particle size of 68 nm. The NPs were then coated with oleic acid (OA) and surface modified with sodium tricitrate, to increase their stability and biocompatibility, and well-dispersed NPs were obtained with sizes below 30 nm. TEM investigations revealed the presence of hybrid clusters with nanoparticle - OA structures, indicating that FeB nanoparticles were stabilized by being embedded in OA clusters, forming both agglomerated sub-micron and free nano-sized structures. Obtained NPs showed ferromagnetic property, with a saturation magnetization of 25.9 emu/g and a low coercivity of 90 Oe. As a result of testing different types of healthy and cancer cell lines with NPs, Zn-doped-FeB@OA NPs exhibited a high biocompatibility. Results suggested that highly biocompatible and magnetic OA-coated Zn-doped FeB particles can be potential candidates for biomedical applications such as medical imaging or drug delivery systems.