WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

Permanent URI for this collectionhttps://hdl.handle.net/11147/7150

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Author: search.filters.author.Emrullahoglu, MustafaSubject: search.filters.subject.Synthesis

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  • Article
    Design, Synthesis, and Biological Evaluation of Novel Water-Soluble Quinoline-Based Conjugates with Antioxidant, Antimicrobial, and DNA-Binding Activities
    (Society of Chemists and Technologists Madeconia, 2025) Emrullahoğlu, Mustafa; Okumus, Veysi; Emrullahoglu, Mustafa; Gumus, Selcuk; 04.04. Department of Photonics; 04. Faculty of Science; 01. Izmir Institute of Technology
    Considering the extremely valuable biological and pharmaceutical properties of quinolines, novel water-soluble quinoline-based conjugates were designed and synthesized. In vitro antioxidant activities, such as free radical scavenging, metal chelating, and reducing-power activities, of the newly synthesized compounds (WQ-1, WQ-2, WQ-3, WQ-4, and WQ-5) were determined. Although the highest scavenging activity (41.21 +/- 1.18%) and chelating activity (23.53 +/- 0.97%) at a concentration of 500.0 mu g/ml were observed in WQ-4, it was determined that WQ-5 had the highest reducing-power ability (0.417 +/- 0.0116). The synthesized compounds were also tested for their antimicrobial activities against two Grampositive and two Gram-negative bacteria, and it was determined that only WQ-3 showed low activity against Enterococcus hirae and Staphylococcus aureus. DNA-binding activities of the compounds were also studied using calf thymus DNA (CT-DNA). Additionally, the three-dimensional geometries and some electronic properties of the synthesized compounds were investigated with the density functional theory approach at B3LYP/6-31++G(d,p) level of theory.