WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

Permanent URI for this collectionhttps://hdl.handle.net/11147/7150

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1996 - 199932000 - 200965

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COAR Access Rights: search.filters.coarAccessRights.metadata only accessEnd date: 2009

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Now showing 1 - 10 of 68
  • Conference Object
    Nanoscale Surface Modification of Ultrahigh Molecular Weight Polyethylene (UHMWPE) Samples With the W Plus C Ion Implantation
    (Materials Research Soc, 2007) Urkac, E. Sokullu; Oztarhan, A.; Tihminlioglu, F.; Kaya, N.; Budak, S.; Chhay, B.; Ila, D.
    In this work, Ultra High Molecular Weight Poly Ethylene (UHMWPE) samples Were implanted by W + C ions using Metal-Vapour Vacuum Arc (MEVVA) ion implantation system with a fluence of 10(17) ion/cm(2) and extraction voltage of 30 kV. Samples were characterized with Raman Spectra, ATR-FTIR, UV-VIS-NlR Spectrum and RBS. Surface morphology of implanted and unimplanted samples were examined in nanoscale with AFM.
  • Article
    Tc-99m Erythromycin Lactobionate Inhalation Scintigraphy in Parenchymal Lung Diseases
    (Elsevier Science inc, 1999) Durak, H; Aktogu, S; Degirmenci, B; Sayit, E; Ertay, T; Dereli, S
    We have investigated Technetium 99m erythromycin lactobionate (Tc 99m EL) clearance from the lungs after inhalation, in the presence of an alveolitis. Eighteen patients (6 sarcoidosis, 7 idiopathic fibrosis, and 5 miliary tuberculosis) were imaged after the patients inhaled 1,110 MBq of Tc 99m EL. Clearance half time for the first 45 min, for 24 h, and retention at 24 h correlated with percentage of lymphocytes in bronchoalveolar lavage fluid (BAL) (r =.729, r =.883, and r =.826, respectively). There was a positive correlation between peripheral penetration (PP) and forced expiratory volume in 1 s (FEV1) (r =.806) and forced vital capacity (FVC) (r =.781). Retention was more marked in sarcoidosis compared with tuberculosis (0.025 < p less than or equal to 0.05). Radioaerosol lung imaging may reflect the pulmonary function impairment in parenchymal lung diseases. Retention of Tc 99m EL may be related to number of BAL cells or presence of a lymphocytic alveolitis. Long residency time of Tc 99m EL in the lungs implies that erythromycin can also be administered by inhalation for therapeutic purposes. NUCL MED BIOL 26;6:695-698, 1999. (C) 1999 Elsevier Science Inc. All rights reserved.
  • Article
    Citation - WoS: 37
    Mechanisms of Cellular Resistance To Imatinib in Human Chronic Myeloid Leukemia Cells
    (Taylor and Francis Ltd., 2007) Baran, Yusuf; Ural, Ali Uğur; Gündüz, Ufuk
    A major advancement in the treatment of chronic myeloid leukemia (CML) has been the development of imatinib, which has shown striking activity in the chronic phase and the accelerated phase, but less so in the blast phase of the disease. Despite high rates of hematologic and cytogenetic responses to therapy, the emergence of resistance to imatinib has been recognized as a major problem in the treatment of patients with CML. Various cellular mechanisms may be involved in the nature of cellular resistance. Increased amount of target, alteration in structure of target proteins, decreased drug uptake and increased detoxification are well-known mechanisms of resistance. On the other hand, in some cases, even if anticancer drugs reach their sites of action, bypassing drug efflux system of the cells, some cells still may survive via the dysregulation of apoptotic signalling. In this study, mechanisms of resistance to imatinib-induced apoptosis in human Meg-01 CML cells were examined. Continuous exposure of cells to step-wise increasing concentrations of imatinib resulted in the selection of 200- and 1000 nM imatinib-resistant sub-lines referred to as Meg-01/IMA-0,2 and Meg-01/1MA-1, respectively. MTT cell proliferation, cell cycle analyses and trypan blue dye exclusion analyses showed that Meg-0l/IMA-1 cells were resistant to imatinib-induced apoptosis as compared to parental sensitive cells. There was an increased expression of BCR/ABL, Bcl-2 and an increase in mitochondrial membrane potential (MMP) detected in resistant cells comparing to parental sensitive cells. There was no mutation detected in imatinib binding site of ABL kinase region. Various diverse mechanisms have been reported for their involvement in the multidrug resistance. In this study, it has been shown that the degree of BCR/ABL expression appears to be directly proportional to the levels of imatinib resistance. In addition, there have been BCR/ABL-independent mechanisms reported for deriving resistance against imatinib. Our results revealed that besides BCR/ABL overexpression, imatinib resistance also depends on the inhibition of apoptosis as a result of up-regulation of anti-apoptotic stimuli and down-regulation of pro-apoptotic stimuli through MMP but does not depend on any mutation on imatinib binding site of ABL kinase.
  • Article
    Citation - WoS: 13
    Citation - Scopus: 15
    Design, Performance, and Calibration of the Cms Hadron-Outer Calorimeter
    (Springer Verlag, 2008) Karapınar, Güler
    The Outer Hadron Calorimeter (HCAL HO) of the CMS detector is designed to measure the energy that is not contained by the barrel (HCAL HB) and electromagnetic (ECAL EB) calorimeters. Due to space limitation the barrel calorimeters do not contain completely the hadronic shower and an outer calorimeter (HO) was designed, constructed and inserted in the muon system of CMS to measure the energy leakage. Testing and calibration of the HO was carried out in a 300 GeV/c test beam that improved the linearity and resolution. HO will provide a net improvement in missing E T measurements at LHC energies. Information from HO will also be used for the muon trigger in CMS. © 2008 Springer-Verlag / Società Italiana di Fisica.
  • Article
    Citation - WoS: 2
    The Development of Western-Type Large-Scale Consumption Areas in Turkey and Legal and Structural Regulation Efforts in Urban Retail Environments
    (Yıldız Teknik Üniversitesi, 2009) Kompil, Mert; Celik, Murat
    The retail sector has been experiencing a rapid and continuous change worldwide. There have also been profound changes in Turkey, especially after the 1980s. Both the retail sector and the urban retail environments have been altered radically. One of the most significant indicators of this change is the proliferation of western-type large-scale retail developments. Past experiences in developed countries have shown that the uncontrolled development of large-scale retail areas results in some undesired socioeconomic and physical outcomes, such as decline in the cultural and commercial activities of city centers, damage in existing retail workforce structure, and change in local retail hierarchy, nearby land uses, traffic loads and original architectural identity. Many countries have put into practice restrictive and regulatory policies to prevent these negative effects. As similar transformations have also been realized in Turkish retail environments, many institutions think that similar legal regulations must be implemented in Turkey as well. The present study investigates the ongoing retail change within the Turkish context, explores the legal and structural regulatory policies of the Organization for Economic Co-operation and Development (OECD) countries, and critically discusses the appropriate retail regulation policies for Turkey.
  • Article
    Efficient Design of Nursing Unit Floors
    (Yıldız Teknik Üniversitesi, 2009) Kazanasmaz, Z. Tugce; Duzgunes, Arda
    Hospital designs aim to obtain the lowest possible construction, maintenance and operational costs together with patient satisfaction, comfort and privacy. To satisfy these needs, the efficient design of nursing unit areas becomes considerably important. This study was thus conducted to analyze planimetric design efficiency of nursing unit floors by defining certain floor areas and floor area ratios. To test existing nursing unit floors, quantitative assessments were noted in regard to their planimetric efficiency: the utility value of the built floor area, both in terms of its allocation to patient space (served), support (serving) and circulation space and the relative proportions of these. Results were presented in a comparative table. Of the 15 hospital floor plans analyzed, five satisfied minimum space requirements for patient areas, while another five were in the optimum range for circulation areas. Two were defined as the least efficient, having the lowest patient-to-circulation area ratio.
  • Correction
    Citation - WoS: 4
    Citation - Scopus: 2
  • Conference Object
    A Boundary Element Method for Axisymmetric Elastodynamic Analysis
    (John Wiley and Sons Inc., 1996) Özkan, Gonca; Mengi, Yalçın
    A new numerical method is proposed for the boundary element analysis of axisymmetric bodies. The method is based on complex Fourier series expansion of boundary quantities in circumferential direction, which reduced the boundary element equation to an integral equation in (r-z) plane involving the Fourier coefficients of boundary quantities, where r and z are the coordinates of the r theta z cylindrical coordinate system. The kernels appearing in these integral equations can be computed effectively by discrete Fourier transform formulas together with the fast Fourier transform (FFT) algorithm, and the integral equations (r-z) plane can be solved by Gaussian quadrature, which establishes the Fourier coefficients associated with boundary quantities. The Fourier transform solution can then be inverted into r theta z space by using again discrete Fourier transform formulas together with FFT algorithm. In this paper, we present the formulation of the proposed method which is outlined above. A comparison is given between the existent methods in literature and our method, which shows that the use of FFT algorithm for the integrations in circumferential direction provides considerable saving in computer time.
  • Conference Object
    Optimization of Mass Spectrometric Ionisation Efficiency Data
    (Springer Verlag, 1997) Özgen, İsmet Tamerkan; Altungöz, Oya; Salih, B.; Vandeginste, B. G. M.
    A new method is developed and tested to find out the excited electronic and vibrational energy levels (fine structure) of molecules from mass spectrometric ionisation efficiency data which were obtained by a conventional mass spectrometer ion source having normal electron energy distribution. Electrons emitted in a conventional mass spectrometer ion source are not monoenergetic, therefore, evaluation of Ionisation Potentials (IF) and Appearance Potentials (AP) from experimental data creates some problems. This is even worse in the evaluation of Fine Structure (excited electronic and vibrational energy levels) from ionisation efficiency data [1]. This is overcome either by using specially designed monoenergetic ion sources which have their own problems (manufacture of special design, difficulty of operation, too much decrease of ion current), or by eliminating disturbing effects in the ionisation efficiency data by some deconvolution techniques [2,4,5,6,7,9]. In this study attempts were made to eliminate the deteriorating effects (mainly arising from electron energy distribution and noise) in the ionisation efficiency data by a deconvolution technique. The technique was applied to the ionisation efficiency data of molecular nitrogen,oxygen and methylammine and its fragment and interesting results were obtained.
  • Conference Object
    Problem of Cracked Infinite Hollow Cylinder With Two Rigid Inclusions
    (Civil-Comp Press, 2000) Artem, Hatice Seçil; Geçit, Mehmet Ruşen
    This paper is concerned with the fracture of an axisymmetric hollow cylindrical bar containing rigid inclusions. The cylinder is under the action of uniformly distributed axial tension applied at infinity. The hollow cylinder contains a ring-shaped crack at the symmetry plane whose surfaces are free of tractions and two ring-shaped rigid inclusions with negligible thickness symmetrically located on both sides of the crack. Geometry and the loading is symmetric about z-axis. Along the rigid inclusions displacements are constant and continuous whereas stresses have jumps. The inner and the outer surfaces of the cylinder are free of tractions It is assumed that the material of the cylinder is linearly elastic and isotropic. The mixed boundary conditions of the problem lead the analysis to a system of three singular integral equations for crack surface displacement derivative and normal and shear stress jumps on rigid inclusions. These integral equations are solved numerically and the stress intensity factors at the edges of the crack and at the edges of the inclusions are calculated. Results are presented in graphical form.