WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
Permanent URI for this collectionhttps://hdl.handle.net/11147/7150
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Article Effect of Marination on the Formation of Polycyclic Aromatic Hydrocarbons in Grilled Vegetables(Wiley, 2025) Kacmaz Ozcetin, Sibel; Artok, LeventThe effect of marination on the formation of polycyclic aromatic hydrocarbons (PAH) in charcoal-grilled vegetables was studied. Various marinade ingredients, including apple cider vinegar, red grape vinegar, lemon juice, garlic powder, black pepper, and the food additive tert-butylhydroquinone (TBHQ) were applied to vegetable samples before charcoal grilling. The total phenolic content (TPC) and total antioxidant capacity (TAC) of each marinade ingredient were assessed for their contribution to PAH inhibition. A substantial decrease in PAH4 formation was observed in marinated vegetables. Red grape vinegar exhibited the strongest average inhibitory effect on total PAH4 formation (75%), followed by apple vinegar (68%), lemon juice (52%), garlic powder (34%), and black pepper (30%). Additionally, the TBHQ (67%) demonstrated a strong inhibitory effect, reducing total PAH4 formation by 67%. These findings offer valuable insights for reducing PAH levels in grilled vegetables and preventing their formation.Review Domestic Devotions in the Early Modern World(Univ Art Assoc Canada, 2020) Andersen, Angela; Gunduz, CanArticle Role of Long Non-Coding RNA X-Inactive Transcript (XIST) in Neuroinflammation and Myelination: Insights From Cerebral Organoids and Implications for Multiple Sclerosis(MDPI, 2025) Pepe, Nihan Aktas; Acar, Busra; Zararsiz, Gozde Erturk; Guner, Serife Ayaz; Sen, AlaattinBackground/Objectives: X-inactive-specific transcript (XIST) is a factor that plays a role in neuroinflammation. This study investigated the role of XIST in neuronal development, neuroinflammation, myelination, and therapeutic responses within cerebral organoids in the context of Multiple Sclerosis (MS) pathogenesis. Methods: Human cerebral organoids with oligodendrocytes were produced from XIST-silenced H9 cells, and the mature organoids were subsequently treated with either FTY720 or DMF. Gene expression related to inflammation and myelination was subsequently analyzed via qRT-PCR. Immunofluorescence staining was used to assess the expression of proteins related to inflammation, myelination, and neuronal differentiation. Alpha-synuclein protein levels were also checked via ELISA. Finally, transcriptome analysis was conducted on the organoid samples. Results: XIST-silenced organoids presented a 2-fold increase in the expression of neuronal stem cells, excitatory neurons, microglia, and mature oligodendrocyte markers. In addition, XIST silencing increased IL-10 mRNA expression by 2-fold and MBP and PLP1 expression by 2.3- and 0.6-fold, respectively. Although XIST silencing tripled IBA1 protein expression, it did not affect organoid MBP expression. FTY720, but not DMF, distinguished MBP and IBA1 expression in XIST-silenced organoids. Furthermore, XIST silencing reduced the concentration of alpha-synuclein from 300 to 100 pg/mL, confirming its anti-inflammatory role. Transcriptomic and gene enrichment analyses revealed that the differentially expressed genes are involved in neural development and immune processes, suggesting the role of XIST in neuroinflammation. The silencing of XIST modified the expression of genes associated with inflammation, myelination, and neuronal growth in cerebral organoids, indicating a potential involvement in the pathogenesis of MS. Conclusions: XIST may contribute to the MS pathogenesis as well as neuroinflammatory diseases such as and Alzheimer's and Parkinson's diseases and may be a promising therapeutic target.Article Decision-Support Approaches for Sustainable Water Resource Management in Northwest Algeria(Polish Society of Ecological Engineering – PTIE, 2025) Meskine, Ahmed; Cherif, El Amine; Zerouali, Bilel; Ouadja, Abid; Santos, Celso Augusto Guimaraes; Bailek, Nadjem; Baba, AlperThis study investigates water resource management in the Wilaya of Mostaganem, northwest Algeria, using the water evaluation and planning (WEAP) decision support tool in combination with the analytic hierarchy process (AHP). As water scarcity becomes increasingly critical due to population growth, agricultural demands, and climate variability, effective management strategies are essential. This research employs WEAP to simulate various water demand and supply scenarios, assessing the impacts of irrigation efficiency, industrial development, and climate conditions on water availability. Under the ASI scenario, unsatisfied water demand may reach 4.3 hm3 per year by 2027. However, improving irrigation efficiency could reduce this by up to 50% compared to the reference scenario. Seasonal variations reveal deficits reaching 3.2 hm3 per month during the summer months of July through October. Additionally, the study highlights that a significant increase in water demand, exceeding 80 hm3 by 2060, can be mitigated through improved water supply initiatives, such as constructing new dams. The integration of AHP enables the prioritization of management strategies based on stakeholder preferences, demonstrating that adapting to climate change can stabilize demand below 50 million cubic meters. This integrated approach provides valuable insights for policymakers and stakeholders in developing sustainable water resource strategies that address the challenges faced by the Mostaganem region.Article Plasma Proteomic Markers of Interleukin-1β Pathway Associated With Incident Age-Related Macular Degeneration in Persons With Aids(Elsevier, 2025) Hunt, Peter W.; Olshen, Adam B.; Murad, Natalia; Ambayec, Gabrielle C.; Sezgin, Efe; Schneider, Michael F.; Jabs, Douglas A.Objective To evaluate the associations of plasma inflammatory proteins with age-related macular degeneration (AMD) in persons with the AIDS, using a discovery-based proteomics approach. Design A nested case-control study (analysis 1) and nested cohort study (analysis 2). Participants Persons with AIDS enrolled in the Longitudinal Study of the Ocular Complications with AIDS (LSOCA). Methods Cryopreserved plasma specimens obtained at baseline were assayed for inflammatory proteins using the Olink Inflammation Explore Panel 1. In analysis 1, baseline proteomic profiles for 26 persons with AIDS and incident intermediate-stage AMD 5 to 10 years after baseline and 49 matched controls (matched for age, biologic sex, race/ethnicity, and follow-up) without AMD were compared. In analysis 2, 475 persons from LSOCA with baseline plasma inflammatory proteomic profile measurements were followed for incident cataract and mortality. Main Outcome Measures Incident intermediate-stage AMD; incident cataract; and mortality. Results Of 365 measurable plasma inflammatory proteins, 118 (32%) were associated with incident intermediate-stage AMD at the false discovery rate-adjusted Q < 0.05 level after adjustment for smoking, CD4+ T count, and plasma human immunodeficiency virus RNA level. Gene ontology pathway enrichment analysis identified the interleukin (IL)-1 beta pathway and wound healing pathways, including tissue inhibitor of metalloproteinase 3, as significantly associated with incident AMD. These associations were qualitatively different from those associated with incident cataracts, where elevated levels of inflammatory proteins were associated with a decreased risk of cataracts. A much broader number of inflammatory pathways, including those related to the adaptive immune system, were associated with mortality. Conclusions Upregulation of the IL-1 beta pathway appears to be associated with an increased risk of incident AMD in persons with AIDS. Given the availability of inhibitors of this pathway, inhibition of the IL-1 beta pathway may provide a therapeutic avenue for treatment of AMD. Financial Disclosure(s) Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article. Ophthalmology Science 2025;5:100794 (c) 2025 by the American Academy of Ophthalmology. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).Article Demystifying Power and Performance Variations in Gpu Systems Through Microarchitectural Analysis(Comsis Consortium, 2025) Topcu, Burak; Karabacak, Deniz; Oz, IsilGraphics Processing Units (GPUs) serve efficient parallel execution for general-purpose computations at high-performance computing and embedded systems. While performance concerns guide the main optimization efforts, power issues become significant for energy-efficient and sustainable GPU executions. Profilers and simulators report statistics about the target execution; however, they either present only performance metrics in a coarse kernel function level or lack visualization support that can enable microarchitectural performance analysis or performance-power consumption comparison. Evaluating runtime performance and power consumption dynamically across GPU components enables a comprehensive tradeoff analysis for GPU architects and software developers. In this work, we present a novel memory performance and power monitoring tool for GPU programs, GPPRMon, which performs a systematic metric collection and provides useful visualization views to guide power and performance analysis for target executions. Our simulation-based framework dynamically gathers SM and memory-related microarchitectural metrics by monitoring individual instructions and reports dynamic performance and power values. Our interface presents spatial and temporal views of the execution. While the first demonstrates the performance and power metrics across GPU memory components, the latter shows the corresponding information at the instruction granularity in a timeline. We demonstrate performance and power analysis for memory-bound graph applications and resource-critical embedded programs from GPU benchmark suites. Our case studies reveal potential usages of our tool in memory-bound kernel identification, performance bottleneck analysis of a memory-intensive workload, performance-power evaluation of an embedded application, and the impact of input size on the memory structures of an embedded system.Article Citation - WoS: 8Citation - Scopus: 8A Review of the Experimental and Numerical Studies on the Compression Behavior of the Additively Produced Metallic Lattice Structures at High and Low Strain Rates(KeAi Communications Co., 2025) Bin Riaz, Muhammad Arslan; Guden, MustafaRecent advances in additive manufacturing have enabled the construction of metallic lattice structures with tailored mechanical and functional properties. One potential application of metallic lattice structures is in the impact load mitigation where an external kinetic energy is absorbed by the deformation/ crushing of lattice cells. This has motivated a growing number of experimental and numerical studies, recently, on the crushing behavior of additively produced lattice structures. The present study overviews the dynamic and quasi-static crushing behavior of additively produced Ti64, 316L, and AlSiMg alloy lattice structures. The first part of the study summarizes the main features of two most commonly used additive processing techniques for lattice structures, namely selective-laser-melt (SLM) and electrobeam-melt (EBM), along with a description of commonly observed process induced defects. In the second part, the deformation and strain rate sensitivities of the selected alloy lattices are outlined together with the most widely used dynamic test methods, followed by a part on the observed microstructures of the SLM and EBM-processed Ti64, 316L and AlSiMg alloys. Finally, the experimental and numerical studies on the quasi-static and dynamic compression behavior of the additively processed Ti6 4, 316L, and AlSiMg alloy lattices are reviewed. The results of the experimental and numerical studies of the dynamic properties of various types of lattices, including graded, non-uniform strut size, hollow, non-uniform cell size, and bio-inspired, were tabulated together with the used dynamic testing methods. The dynamic tests have been noted to be mostly conducted in compression Split Hopkinson Pressure Bar (SHPB) or Taylor-and direct-impact tests using the SHPB set-up, in all of which relatively small-size test specimens were tested. The test specimen size effect on the compression behavior of the lattices was further emphasized. It has also been shown that the lattices of Ti6 4 and AlSiMg alloys are relatively brittle as compared with the lattices of 316L alloy. Finally, the challenges associated with modelling lattice structures were explained and the micro tension tests and multi-scale modeling techniques combining microstructural characteristics with macroscopic lattice dynamics were recommended to improve the accuracy of the numerical simulations of the dynamic compression deformations of metallic lattice structures. (c) 2025 China Ordnance Society. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co. Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/ licenses/by-nc-nd/4.0/).Article Citation - WoS: 3Citation - Scopus: 3Numerical Assessment of Vertical Axis Hydrokinetic Turbine Efficiencies With Different Grate Protections(Inst Engineering Technology-IET, 2025) Karakaya, Derya; Elci, SebnemHydrokinetic turbines are crucial for sustainable power generation, but their performance is often impacted by floating debris and sediment transport, which can damage turbine blades. Sediment retention enhances the turbine's lifespan and reduces maintenance by preventing blade erosion, cavitation and clogging. Protective grates reduce abrasive particle entry, minimising blade wear. They also avoid buildup of sediment, lowering the risk of blockages and cavitation, which harm efficiency and accelerate degradation. This study presents the numerical performance of Darrieus-type vertical axis hydrokinetic turbines under the impact of straight and Coanda type grate protection structures. The effects of these two types of grate structures with different design angles on turbine power coefficient (CP) and torque coefficient (CT) were investigated using the ANSYS Fluent program. The dynamic mesh technique simulated the turbine rotation and the semi-implicit method for pressure-linked equations (SIMPLE) was applied with a shear stress transport (SST) k-omega turbulence model. The turbine's efficiency was compared and the results were evaluated for steady and unsteady flow conditions. The highest power coefficients were obtained as 0.230 and 0.264 for steady and unsteady flow, respectively, in the Coanda grate with a 30 degrees central angle. The highest power coefficients were obtained as 0.215 and 0.247 for steady and unsteady flow, respectively, in the straight grate design with a 60 degrees inclination angle. The sediment retention capacities of Coanda grates (30 degrees central angle) and straight grates (60 degrees inclination angle) with varying particle size distributions were further investigated using the discrete phase model (DPM) under steady flow conditions.Article Citation - WoS: 6Citation - Scopus: 7Physics-Based Machine Learning for Modeling of Laminated Composite Plates Based on Refined Zigzag Theory(Springer, 2025) Ermis, Merve; Dorduncu, Mehmet; Aydogan, GokayPhysics-based machine learning techniques have recently gained prominence for their ability to model complex material and structural behavior, particularly in laminated composite structures. This study introduces an innovative approach, being the first to employ physics-informed neural networks (PINNs) in conjunction with refined zigzag theory (RZT) for the stress analysis of laminated composite plates. A multi-objective loss function integrates governing partial differential equations (PDEs) and boundary conditions, embedding physical principles into the analysis. Using multiple fully connected artificial neural networks, called feedforward deep neural networks, tailored to handle PDEs, PINNs are trained using automatic differentiation. This training process minimizes a loss function that incorporates the PDEs governing the underlying physical laws. RZT, particularly suitable for the stress analysis of thick and moderately thick plates, simplifies the formulation by using only seven kinematic variables, eliminating the need for shear correction factors. The capability of the proposed method is validated through several benchmark cases in stress analysis, including 3D elasticity solutions, analytical solutions, and experimental results from a three-point bending test based on displacement measurements reported in the literature. These results show consistent agreement with the referenced solutions, confirming the accuracy and reliability of the proposed method. Comprehensive evaluations are conducted to examine the effects of softcore presence, elastic foundation, various lamination schemes, and differing loading and boundary conditions on the stress distribution in laminated plates.Article Citation - WoS: 1Legume and Nut Flours From the Mediterranean Area: Proximate Compositions, Techno-Functionalities, and Spectroscopy Patterns as a Function of Species, Origin, and Treatment(Elsevier, 2025) Cappa, Carola; Ozen, Banu; Tokatli, Figen; Imeneo, Valeria; Aguilo-Aguayo, Ingrid; Sahan, Yasemin; Alamprese, CristinaThis study systematically evaluates proximate composition, color, techno-functionalities, and spectroscopy patterns of 19 legume and 16 nut commercial flours of the Mediterranean area. Effect of species, origin, and treatment were analyzed using a Generalized Linear Model. Except for legume proteins, species and origin significantly (p <= 0.001) affected flour composition, while heat treatment only had a significant effect (p <= 0.05) on nuts. A large variability was observed in fats (0.6-69 g/100g) and proteins (3.7-36 g/100g), and the FT-IR spectra reflected the 35-flours composition. Principal component model clearly distinguished flours based on their carbohydrate, fat, and protein contents. For legumes, color indices, bulk density, and emulsifying properties were significantly affected by species, origin, and treatment, while foaming properties were influenced only by species. For nuts, oil absorption capacity, emulsion properties, and foaming properties were significantly affected by species, origin, and treatment. The origin had a significant effect on water retention capacity (40-433 %) of nuts. The study findings contribute to a better knowledge of Mediterranean legume and nut flours, clarifying their distinct properties for a higher awareness in their use for the design of food products with tailored features.