WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
Permanent URI for this collectionhttps://hdl.handle.net/11147/7150
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Article Citation - WoS: 37Mechanisms of Cellular Resistance To Imatinib in Human Chronic Myeloid Leukemia Cells(Taylor and Francis Ltd., 2007) Baran, Yusuf; Ural, Ali Uğur; Gündüz, UfukA major advancement in the treatment of chronic myeloid leukemia (CML) has been the development of imatinib, which has shown striking activity in the chronic phase and the accelerated phase, but less so in the blast phase of the disease. Despite high rates of hematologic and cytogenetic responses to therapy, the emergence of resistance to imatinib has been recognized as a major problem in the treatment of patients with CML. Various cellular mechanisms may be involved in the nature of cellular resistance. Increased amount of target, alteration in structure of target proteins, decreased drug uptake and increased detoxification are well-known mechanisms of resistance. On the other hand, in some cases, even if anticancer drugs reach their sites of action, bypassing drug efflux system of the cells, some cells still may survive via the dysregulation of apoptotic signalling. In this study, mechanisms of resistance to imatinib-induced apoptosis in human Meg-01 CML cells were examined. Continuous exposure of cells to step-wise increasing concentrations of imatinib resulted in the selection of 200- and 1000 nM imatinib-resistant sub-lines referred to as Meg-01/IMA-0,2 and Meg-01/1MA-1, respectively. MTT cell proliferation, cell cycle analyses and trypan blue dye exclusion analyses showed that Meg-0l/IMA-1 cells were resistant to imatinib-induced apoptosis as compared to parental sensitive cells. There was an increased expression of BCR/ABL, Bcl-2 and an increase in mitochondrial membrane potential (MMP) detected in resistant cells comparing to parental sensitive cells. There was no mutation detected in imatinib binding site of ABL kinase region. Various diverse mechanisms have been reported for their involvement in the multidrug resistance. In this study, it has been shown that the degree of BCR/ABL expression appears to be directly proportional to the levels of imatinib resistance. In addition, there have been BCR/ABL-independent mechanisms reported for deriving resistance against imatinib. Our results revealed that besides BCR/ABL overexpression, imatinib resistance also depends on the inhibition of apoptosis as a result of up-regulation of anti-apoptotic stimuli and down-regulation of pro-apoptotic stimuli through MMP but does not depend on any mutation on imatinib binding site of ABL kinase.Article Citation - WoS: 1Princesses Versus Maids: Domesticating Electricity in the Early Republican Period in Turkey(Taylor and Francis Ltd., 2019) Emgin, BaharThis article is concerned with the question of how electricity was introduced into the home in Turkey during a period when electrification of the country ran in parallel with the establishment of the new republic. Republican discourses of modernization and progress attributed electricity a symbolic transformative power. Yet, the robust power of electricity had to be domesticated before it was introduced into the homes to comply with the ideal of modern home. Visual representations of electricity constituted a crucial step in this process of domestication. To figure out the visual strategies of domestication the study focuses on the representations of electricity produced by prominent mediators of domestic electricity during the period. These include the bi-monthly publication of Istanbul's electric providerSociete Anonyme d'Installations Electriques(SATIE) namedAmeli Elektrikand prominent women's and family magazines of the period, which areYedigunandEv-Is. Dwelling on advertisement images, cover illustrations and promotional pieces, this article identifies two main visual strategies of domestication, namely mythification and anthropomorphization. Throughout the text it is argued that visual representations of electricity for residential users undermined the quasi-neutral definition of electricity as a modern power and rather worked to frame electricity as a means of distinction and pictured a pretentious modernity.Correction Corrigendum To “ankos Publisher Application System and Its Impact on the E-Resource Evaluation Process” [serials Review 39 (2013) 29–36](Taylor and Francis Ltd., 2013) Bulut, Burcu; Uğur, Handan; Gürdal, Gültekin; Holt, İlkay; Çukadar, Sami; Akbayrak, Emre H.; Çelebi, Mustafa K.[No abstract available]Conference Object Citation - WoS: 7Modeling of Low Temperature Geothermal District Heating Systems(Taylor and Francis Ltd., 2004) Yıldırım, Nurdan; Gökçen, GüldenIn this work, low temperature geothermal district heating systems with heat pumps have been studied and compared with fuel-oil boiler heating systems for intermittent and continuous regimes according to the optimum indoor air temperature and operational cost. Izmir Institute of Technology (IZTECH) Campus is taken as a case study. Various heat pump and boiler configurations are studied to meet required duty. Operational cost analysis for each alternative is conducted. According to the results, for IZTECH Campus the best alternative, which gives the optimum indoor air temperature and the lowest operational cost, is heat pump continuous regime.Conference Object Detection of Urban Change Using Remote Sensing and Gis: Izmir Case(Taylor and Francis Ltd., 2008) Tarhan, Çiğdem; Arkon, Cemal; Çelik, M.; Gümüştekin, Şevket; Tecim, V.This study is an example of how land use changes could be detected via high resolution remotely sensed data. In order to perform "change detection" IKONOS satellite images, belonging to 2001 and 2004, have been used. An automated Graphical User Interface (GUI) has been created for detection of environment. Different image enhancement techniques and a fuzzy inference system have been combined in the GUI. The detection results are classified according to some basic levels such as 20-50% and 70%. Additionally, four different change detection algorithms have been applied which are pixel-based, object based, feature based. These algorithms have been examined according to change detection levels with different image enhancement techniques. At the end of the study, the results have been compared.Conference Object Citation - Scopus: 5High Arsenic Levels in Water Resources Resulting From Alteration Zones: a Case Study From Biga Peninsula, Turkey(Taylor and Francis Ltd., 2010) Baba, Alper[No abstract available]Book Part Nucleic acid biochemistry: Food applications(Taylor and Francis Ltd., 2010) Kurnaz, Işıl A.; Ceylan, Çağatay[No abstract available]Book Part Citation - WoS: 1Resource management techniques for OFDMA(Taylor and Francis Ltd., 2010) Le Ruyet, Didier; Özbek, Berna[No abstract available]Book Part Citation - WoS: 2Modeling and Simulation Tools for Mobile Ad Hoc Networks(Taylor and Francis Ltd., 2012) Erciyes, Kayhan; Dağdeviren, Orhan; Çokuslu, Deniz; Yılmaz, Onur; Gümüş, Hasan[No abstract available]Book Part Citation - WoS: 2Rapid Development of Geothermal Power Generation in Turkey(Taylor and Francis Ltd., 2014) Karadaş, Murat; Gökçen Akkurt, Gülden[No abstract available]