WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
Permanent URI for this collectionhttps://hdl.handle.net/11147/7150
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Article Citation - WoS: 8Protective and Therapeutic Effects of Milrinone on Acoustic Trauma in Rat Cochlea(Springer, 2019) Ceylan, Seyit Mehmet; Uysal, Erdal; Altinay, Serdar; Sezgin, Efe; Bilal, Nagihan; Petekkaya, Emine; Gulbagci, Mustafa EmreObjectiveThe aim of this study was to investigate the potential protective and therapeutic effects of milrinone, a specific phosphodiesterase (PDE) III inhibitor, on acoustic trauma-induced cochlear injury and apoptosis.MethodsA total number of 30 healthy Wistar albino rats were evenly divided into five groups as follows: group 1 was assigned as control group; group 2 and 3 were assigned as low-dosage groups (0.25mg/kg) in which milrinone was administered 1h before acoustic trauma (AT) and 2h after AT, respectively; group 4 and 5 were assigned as high-dosage groups (0.50mg/kg) in which the drug was administered 1h before AT and 2h after AT, respectively. Except control group, all treatment groups received a single dosage of milrinone for 5days. Distortion product otoacoustic emissions (DPOAE) measurements were recorded before AT as well as at second and fifth post-traumatic days. At the end of fifth day, all rats were sacrificed and the cochlea of the rats was removed for histopathological evaluation. In addition, the groups were compared in terms of apoptotic index via caspase-3 staining.ResultsIn terms of signal-to-noise ratio (SNR), there was no statistically significant difference among the groups following AT (p>0.05). After 5days of milrinone treatment, the best SNR values were found in group 5, though all groups did not statistically differ (p>0.05). In histopathological evaluation, vacuolization, inflammation, and edema scores in all treatment groups were statistically lower than those of the control group (p<0.05). In group 2 and 4 where the drug was administered before AT, the inflammation and apoptosis index was lower than those of group 3 and 5 where the drug was administered after AT (p<0.0001).ConclusionWe reveal that milrinone has a protective effect on cochlear damage in the experimental acoustic model of rats. This protective effect was more apparent following the pre-traumatic milrinone administration, and is associated with its effect on decreasing inflammation and apoptosis. Based on DPOAE measurements following AT, especially in the group 5 (high-dosage group), milrinone may also have a therapeutic effect.Conference Object Suppression of STAT5A Increases Chemotherapeutic Sensitivity in Imatinib-Resistant and Imatinib-Sensitive K562 Cells(Ferrata Storti Foundation, 2010) Baran, Y.; Baran, Yusuf; Kosova, B.; Ekiz, Hüseyin Atakan; Tezcanli, B.; Ekiz, H.; Cakir, Z.; Selvi, S.Article Citation - WoS: 7Design Education for Adaptive Reuse(Archnet-ijar, 2010) Eyuce, Ozen; Eyuce, AhmetBuiltform is subject to various types of obsolences in the course of time. Among these functional obsolesences, taking place as an outcome of ever changing modes of production and consumption, are of crucial importance so far as their fate of existing urban fabric is concerned. Defunct buildings become derelict and often subject to demolition which amounts to the eradication of the collective memory. In this connection the process of adaptive reuse can be defined as the task of adjusting functionally obsolete buildings for new program requirements through building conversion. Adaptive reuse projects entail not only alterations within the boundaries of an existing building envolope but also radical changes/transformations in the space configuration so as to accomodate the new set of functional requirements. Therefore, the development of an architectural design scheme in the light of potentials offered and the constraints imposed by an existing architectural entity is essential. Although adaptive reuse projects require case specific approaches depending on the peculiarities of the original structure three main areas of concern can be discerned during the elaboration of the design scheme. These areas of concerns are the space configuration, tectonic aspects of the context within which the project will be realized. The paper addresses itself to the elucidation of these concern areas and the interrelations with the final scheme.Conference Object Imatinib-Induced Apoptosis; a Possible Link To Topoisomerase Enzyme Inhibition(Ferrata Storti Foundation, 2010) Baran, Y.; Zencir, Z.; Cakir, Z.; Ozturk, E.; Topcu, Z.Conference Object Changes in Protein Profiles of Multiple Myeloma Cells in Response To Bortezomib(Ferrata Storti Foundation, 2012) Baran, Y.; Turan, T.; Sanli-Mohamed, G.Correction Citation - WoS: 11Measurement of Jet Multiplicity Distributions in T(t)over-Bar Production in pp Collisions at √s = 7 TeV (Vol 74, 3014, 2014)(Springer, 2015) Chatrchyan, S.; Khachatryan, V.; Sirunyan, A. M.; Tumasyan, A.; Adam, W.; Bergauer, T.; Woods, N.Conference Object Modeling of Glycolysis(Elsevier Science Bv, 2016) Batur, Aysem; Hamamci, Haluk; Buyukkileci (Sahin), Ceylan; Buyukkileci, Ali OguzArticle Citation - WoS: 15Search for Supersymmetry in pp Collisions at √s=7 TeV in Events With a Single Lepton, Jets, and Missing Transverse Momentum(Springer, 2013) Chatrchyan, S.; Khachatryan, V.; Sirunyan, A. M.; Tumasyan, A.; Adam, W.; Aguilo, E.; Swanson, J.Results are reported from a search for new physics processes in events containing a single isolated high-transverse-momentum lepton (electron or muon), energetic jets, and large missing transverse momentum. The analysis is based on a 4.98 fb(-1) sample of proton-proton collisions at a center-of-mass energy of 7 TeV, obtained with the CMS detector at the LHC. Three separate background estimation methods, each relying primarily on control samples in the data, are applied to a range of signal regions, providing complementary approaches for estimating the background yields. The observed yields are consistent with the predicted standard model backgrounds. The results are interpreted in terms of limits on the parameter space for the constrained minimal supersymmetric extension of the standard model, as well as on cross sections for simplified models, which provide a generic description of the production and decay of new particles in specific, topology based final states.Article Citation - WoS: 36Search for Three-Jet Resonances in pp Collisions at √s=7 TeV(Elsevier, 2012) Chatrchyan, S.; Khachatryan, V.; Sirunyan, A. M.; Tumasyan, A.; Adam, W.; Aguilo, E.; Swanson, J.Results are reported from a search for the production of three-jet resonances in pp collisions at a center-of-mass energy root s = 7 TeV. The study uses the data sample collected by the CMS experiment at the LHC in 2011, corresponding to an integrated luminosity of 5.0 fb(-1). Events with high jet multiplicity and a large scalar sum of jet transverse momenta are analyzed for the presence of resonances in the three-jet invariant mass spectrum. No evidence for a narrow resonance is found in the data, and limits are set on the cross section for gluino pair production in an R-parity-violating supersymmetry model, for gluino masses greater than 280 GeV. Assuming a branching fraction for gluino decay into three jets of 100%, gluino masses below 460 GeV are excluded at 95% confidence level. These results significantly extend the range of previous limits. (C) 2012 CERN. Published by Elsevier By. All rights reserved.Article Citation - WoS: 54Citation - Scopus: 59Measurement of the WZ Production Cross Section in pp Collisions at S=13 TeV(Elsevier, 2017) Khachatryan, V.; Sirunyan, A. M.; Tumasyan, A.; Adam, W.; Asilar, E.; Bergauer, T.; Woods, N.The WZ production cross section in proton-proton collisions at root s = 13 Tev is measured with the CMS experiment at the LHC using a data sample corresponding to an integrated luminosity of 2.3 fb(-1). The measurement is performed in the leptonic decay modes WZ -> lVl'l', where l,l'=e,mu. The measured cross section for the range 60<m (l'l') <120 GeV is sigma(pp -> WZ) = 39.9 +/- 3.2(stat)(2.9)(-3.1)(syst)+/- 0.4(theo)+/- 1.3(lumi)pb, consistent with the standard model prediction.