WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
Permanent URI for this collectionhttps://hdl.handle.net/11147/7150
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Article Biquandle Power Brackets of Oriented Links(Tubitak Scientific & Technological Research Council Turkey, 2025) Güğümcü, Neslihan; Nelson, Sam; 04.02. Department of Mathematics; 04. Faculty of Science; 01. Izmir Institute of TechnologyIn this paper, we introduce biquandle power brackets, an infinite family of invariants of oriented links containing the classical skein invariants and the quandle and biquandle 2-cocycle invariants as special cases. Biquandle power brackets are generalizations of biquandle brackets in which the values of Kauffman states also depend on the biquandle colors they admit. We provide example computations and discuss the relationship between these new invariants and the previous cases.Review Citation - WoS: 1Citation - Scopus: 2Organ-On Platforms for Drug Development, Cellular Toxicity Assessment, and Disease Modeling(Tubitak Scientific & Technological Research Council Turkey, 2024) Khurram, Muhammad Maaz; Bedir, Erdal; Cinel, Gokturk; Yesil Celiktas, Ozlem; Bedir, Erdal; 03.01. Department of Bioengineering; 03. Faculty of Engineering; 01. Izmir Institute of TechnologyOrgans-on-chips (OoCs) or microphysiological platforms are biomimetic systems engineered to emulate organ structures on microfluidic devices for biomedical research. These microdevices can mimic biological environments that enable cell-cell interactions on a small scale by mimicking 3D in vivo microenvironments outside the body. Thus far, numerous single and multiple OoCs that mimic organs have been developed, and they have emerged as forerunners for drug efficacy and cytotoxicity testing. This review explores OoC platforms to highlight their versatility in studies of drug safety, efficacy, and toxicity. We also reflect on the potential of OoCs to effectively portray disease models for possible novel therapeutics, which is difficult to achieve with traditional 2D in vitro models, providing an essential basis for biologically relevant research.Article Citation - WoS: 10Effects of Seismic Activity on Groundwater Level and Geothermal Systems in İzmir, Western Anatolia, Turkey: the Case Study From October 30, 2020 Samos Earthquake(Tubitak Scientific & Technological Research Council Turkey, 2021) Uzelli, Taygun; Baba, Alper; Ozturk, Bahadir; Baba, Alper; Sozbilir, Hasan; Tatar, Orhan; 03.03. Department of Civil Engineering; 01.01. Units Affiliated to the Rectorate; 01. Izmir Institute of Technology; 03. Faculty of EngineeringThe October 30, 2020 Samos earthquake (Mw 6.6) affected the Aegean Sea and environs, caused destruction and loss of life in the city of & Idot;zmir located 70 km away from the earthquake epicenter. Before this earthquake, water resources were monitored in the areas of Bayrakl & imath;, G & uuml;lbah sigma e, and Seferihisar. For this purpose, 10 groundwater monitoring wells were drilled in the Bayrakl & imath; area, where groundwater level, temperature, and electrical conductivity changes were monitored at 1-h intervals in 5 wells. Besides physical parameters such as groundwater levels, temperatures and electrical conductivities, hydrogeochemical cations, and anions measured in the study area. Change in the groundwater levels was observed before, during, and after the Samos earthquake. A trend of rising groundwater level was observed two days before the mainshock, to a height of 10 cm, and the level was maintained till the end of the earthquake. The water levels returned to its original height after about 7 to 10 days of the earthquake. Moreover, electrical conductivity (EC) values were changed because of the interaction with the surrounding rocks and well walls, mixing with different waters during the earthquake shaking. The essential anomalies were observed in the geothermal fields of G & uuml;lbah sigma e and Seferihisar. Due to this earthquake, new geothermal springs emerged along the NE-SW trending G & uuml;lbah sigma e and Tuzla faults, located about 50 to 20 km from the Samos earthquake epicenter, respectively. The new geothermal waters are in Na-Cl composition and similar to other geothermal springs in the region. While the recorded water temperatures in the new geothermal springs vary from 40 to 45 degrees C in Seferihisar, it was measured between 35 and 40 degrees C in G & uuml;lbah sigma e. Due to these anomalies, it is found essential to monitor the effect of the earthquake on the physical and chemical characteristics of the groundwater and its usefulness in earthquake predictions.Article Selective Catalytic Hydrogenation of Cellulose Into Sorbitol With Ru-Based Catalysts(Tubitak Scientific & Technological Research Council Turkey, 2022) Orak, Ceren; Orak, Ceren; Yüksel Özsen, Aslı; 01. Izmir Institute of TechnologySorbitol is one of the platform chemicals and can be produced from various renewable and sustainable sources via different processes. Hydrothermal liquefaction is an effective and promising approach to produce sorbitol, since the subcritical reaction media and appropriate catalysts provide a selective production of platform chemicals. In this study, sorbitol was produced from different renewable sources (cellulose and glucose) in the presence of Ru-based catalysts (Ru/SiO2, Ru/AC, Ru/SBA-15, and Ru/SBA-15-SO3) under subcritical conditions. The highest cellulose conversion was achieved as 90% in the presence of Ru/SBA-15-SO3 for 1 h of reaction duration. The highest sorbitol yield (%) by hydrothermal liquefaction of cellulose was obtained as 6.2% by using Ru/AC for 1 h of reaction duration. A total of 99.9% of glucose conversion was achieved in the presence of all catalysts. The highest sorbitol yield (%) by hydrothermal liquefaction of glucose was found as 3.8% for 1 h of reaction duration. Owing to the results of GC-MS analysis, the intermediate products were identified, and, thus, a reaction pathway was proposed.