WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
Permanent URI for this collectionhttps://hdl.handle.net/11147/7150
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Article Citation - WoS: 1Citation - Scopus: 2The Impact of Genetic Variants Related To the Fatty Acid Metabolic Process Pathway on Milk Production Traits in Jersey Cows(Taylor & Francis inc, 2024) Ardicli, Sena; Senturk, Nursen; Bozkurt, Berkay; Babayev, Huseyn; Selvi, Tugce; Skolnick, Stephen; Cobanoglu, Ozden; 01. Izmir Institute of TechnologyThe synthesis of fatty acids plays a critical role in shaping milk production characteristics in dairy cattle. Thus, identifying effective haplotypes within the fatty acid metabolism pathway will provide novel and robust insights into the genetics of dairy cattle. This study aimed to comprehensively examine the individual and combined impacts of fundamental genes within the fatty acid metabolic process pathway in Jersey cows. A comprehensive phenotypic dataset was compiled, considering milk production traits, to summarize a cow's productivity across three lactations. Genotyping was conducted through PCR-RFLP and Sanger sequencing, while the association between genotype and phenotype was quantified using linear mixed models. Moderate biodiversity and abundant variation suitable for haplotype analysis were observed across all examined markers. The individual effects of the FABP3, LTF and ANXA9 genes significantly influenced both milk yield and milk fat production. Additionally, this study reveals novel two-way interactions between genes in the fatty acid metabolism pathway that directly affect milk fat properties. Notably, we identified that the GGAAGG haplotype in FABP3xLTFxANXA9 interaction may be a robust genetic marker concerning both milk fat yield and percentage. Consequently, the genotype combinations highlighted in this study serve as novel and efficient markers for assessing the fat content in cow's milk. [GRAPHICS]Article W-Locally Isomorphic Torsionless Modules Over Weakly Matlis Domains(Taylor & Francis inc, 2024) Ay Saylam, Basak; Ay Saylam, Başak; Gurbuz, Ezgi; Hamdi, Haleh; 04.02. Department of Mathematics; 04. Faculty of Science; 01. Izmir Institute of TechnologyLet R be an integral domain. An R-module G is torsionless if it is isomorphic to a submodule of a finitely generated free R-module. For torsionless modules, we define w-weak isomorphism types which are new versions of weak isomorphism types with respect to the w-operation: w-local isomorphism and w-nearly isomorphism. Furthermore, we examine the relationship between w-local isomorphism, w-nearly isomorphism, and stable isomorphism for torsionless w-modules over weakly Matlis domains.Article Genetic Factors Associated With Age-Related Macular Degeneration Modulating Plasma Inflammatory Biomarker Levels in Patients With Aids(Taylor & Francis inc, 2024) Sezgin, Efe; Sezgin, Efe; Schneider, Michael F.; Hunt, Peter W.; Beck-Engeser, Gabriele; Ambayac, Gabriele C.; Jabs, Douglas A.; 03.08. Department of Food Engineering; 03. Faculty of Engineering; 01. Izmir Institute of TechnologyIntroductionPatients with the acquired immunodeficiency syndrome (AIDS) have an increased prevalence and incidence of intermediate-stage age-related macular degeneration (AMD). Several elevated plasma inflammatory biomarkers are associated with increased incidence of intermediate-stage AMD in this population. We evaluated the association between AMD risk alleles and plasma inflammatory biomarker levels in persons with AIDS.Materials and MethodsCryopreserved plasma specimens of 229 non-Hispanic White and 252 non-Hispanic blacks from the Longitudinal Study of the Ocular Complications of AIDS cohort were assayed for plasma levels of soluble tumor necrosis factor receptor (sTNFR) 2, interleukin (IL)-18, C x 3motif chemokine ligand 1 (CX3CL1), C-reactive protein (CRP), and soluble CD14 (sCD14). Genotyping included AMD-associated variants rs10801553 and rs800292 for complement factor H (CFH) rs9332739 and rs547154 for complement factor 2 (C2), rs2230199 for C3, rs2285714 for CFI, and rs3732379 and rs3732378 for C x 3motif chemokine receptor 1 (CX3CR1).ResultsIn Whites, AMD low-risk CX3CR1 variants (V249I and T280M) were associated with reduced plasma levels of IL-18. In Blacks, AMD low-risk C3 R102G and low-risk CX3CR1 T280M variants were associated with reduced CRP levels.ConclusionsGenetic variants in AMD-associated immune genes may influence AMD-associated systemic plasma inflammatory biomarker levels in patients with AIDS.Article Citation - WoS: 2Square Impossible Differential Attack and Security of Aes in Known Plaintext Scenario(Taylor & Francis inc, 2024) Kara, Orhun; Kara, Orhun; 04.02. Department of Mathematics; 04. Faculty of Science; 01. Izmir Institute of TechnologyIn this work, we examine the security of the 8-round AES, under the known plaintext attack scenario, a type of cryptographic attack in which an attacker has access to the plaintext and corresponding ciphertext pairs. We present an innovative impossible differential (ID) attack technique, which utilizes a specific ID characteristic, to perform the first known plaintext attack on the 8-round AES with a 256-bit key. Additionally, we propose a new attack methodology, known as the Square Impossible Differential (SID) attack, to enhance the effectiveness of the ID attacks on AES in chosen ciphertext or plaintext scenarios. The SID attack is a combination of a square attack and an ID attack. Our methodology introduces various new approaches, including the key indicator vectors, eliminating the key candidate through the Meet-in-The-Middle technique and mounting the guess and determine attack through the hash tables for the two-round decryption of one column of AES while determining the subkeys constituting the impossible differential characteristic for a given plaintext/ciphertext difference pair. Our approach demonstrates lower computational complexity compared to previous methods, and our analysis shows that the complexities of our known plaintext attack and SID attack are estimated to be 2220 and 2209, respectively.