WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
Permanent URI for this collectionhttps://hdl.handle.net/11147/7150
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Article Citation - WoS: 1Citation - Scopus: 1Real-Time Superficial Vein Imaging System for Observing Abnormalities on Vascular Structures(Springer, 2024) Altay, A.; Gumus, A.Circulatory system abnormalities might be an indicator of diseases or tissue damage. Early detection of vascular abnormalities might have an important role during treatment and also raise the patient’s awareness. Current detection methods for vascular imaging are high-cost, invasive, and mostly radiation-based. In this study, a low-cost and portable microcomputer-based tool has been developed as a Near-Infrared (NIR) superficial vascular imaging device. The device uses NIR Light-Emitting Diode (LED) light at 850 nm along with other electronic and optical components. It operates as a non-contact and safe infrared (IR) imaging method in real-time. Image and video analysis are carried out using OpenCV (Open-Source Computer Vision), a library of programming functions mainly used in computer vision. Various tests were carried out to optimize the imaging system and set up a suitable external environment. To test the performance of the device, the images taken from three diabetic volunteers, who are expected to have abnormalities in the vascular structure due to the possibility of deformation caused by high glucose levels in the blood, were compared with the images taken from two non-diabetic volunteers. As a result, tortuosity was observed successfully in the superficial vascular structures, where the results need to be interpreted by the medical experts in the field to understand the underlying reasons. Although this study is an engineering study and does not have an intention to diagnose any diseases, the developed system here might assist healthcare personnel in early diagnosis and treatment follow-up for vascular structures and may enable further opportunities. © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2023.Article Citation - WoS: 6Citation - Scopus: 5Gelatin-Containing Porous Polycaprolactone Polyhipes as Substrates for 3d Breast Cancer Cell Culture and Vascular Infiltration(Frontiers Media Sa, 2024) Jackson, Caitlin E.; Doyle, Iona; Khan, Hamood; Williams, Samuel F.; Dikici, Betul Aldemir; Ledesma, Edgar Barajas; Claeyssens, FrederikTumour survival and growth are reliant on angiogenesis, the formation of new blood vessels, to facilitate nutrient and waste exchange and, importantly, provide a route for metastasis from a primary to a secondary site. Whilst current models can ensure the transport and exchange of nutrients and waste via diffusion over distances greater than 200 mu m, many lack sufficient vasculature capable of recapitulating the tumour microenvironment and, thus, metastasis. In this study, we utilise gelatin-containing polymerised high internal phase emulsion (polyHIPE) templated polycaprolactone-methacrylate (PCL-M) scaffolds to fabricate a composite material to support the 3D culture of MDA-MB-231 breast cancer cells and vascular ingrowth. Firstly, we investigated the effect of gelatin within the scaffolds on the mechanical and chemical properties using compression testing and FTIR spectroscopy, respectively. Initial in vitro assessment of cell metabolic activity and vascular endothelial growth factor expression demonstrated that gelatin-containing PCL-M polyHIPEs are capable of supporting 3D breast cancer cell growth. We then utilised the chick chorioallantoic membrane (CAM) assay to assess the angiogenic potential of cell-seeded gelatin-containing PCL-M polyHIPEs, and vascular ingrowth within cell-seeded, surfactant and gelatin-containing scaffolds was investigated via histological staining. Overall, our study proposes a promising composite material to fabricate a substrate to support the 3D culture of cancer cells and vascular ingrowth.Conference Object Citation - WoS: 1T Cell Expressed Microrna-155 Promotes Antitumor Immunity and Immune Checkpoint Blockade Responses in Colon Cancer Through Repression of Ship1(Amer Assoc Immunologists, 2023) Tang, William W.; Ekiz, H. Atakan; Voth, Warren P.; Bauer, Kaylyn M.; Barba, Cindy; Ghazaryan, Arevik; Nelson, MorganArticle Citation - WoS: 1Citation - Scopus: 1An Iris Segmentation Scheme Based on Bendlets(Springer London Ltd, 2023) Aghazadeh, Nasser; Abbasi, Mandana; Noras, ParisaDue to the effect of agents such as ambiance, transition channel, and other agents, images are polluted by noise during collection, transition, and compaction, leading to decrease image quality. Noise can decrease the accuracy of the next stages of image processing systems. Therefore, one of the vital stages in the novel processing systems is denoising. This article offers a novel image denoising approach using bendlets. Other multi-scale transformations (such as wavelets, curvelets, and shearlets) cannot recognize properties such as location, direction, and curvature of discontinuities well in piecewise stable images. To solve this problem, bendlets are suggested in this article. Bendlets differ from other multi-scale transformations in that an additional bending parameter is utilized for recognizing the curvature of discontinuities. Bendlets need a fewer number of coefficients to identify curvatures than other multi-scale transformations. Furthermore, they help to make the edges more obvious. The suggested approach is utilized on the UBIRIS.V2 database. It earns better accuracy and stability than other multi-scale transformations.Review Citation - WoS: 5Scientists Without Borders: Lessons From Ukraine [2](Oxford Univ Press, 2023) Wolfsberger, Walter; Chhugani, Karishma; Shchubelka, Khrystyna; Frolova, Alina; Salyha, Yuriy; Zlenko, Oksana; Arych, MykhailoConflicts and natural disasters affect entire populations of the countries involved and, in addition to the thousands of lives destroyed, have a substantial negative impact on the scientific advances these countries provide. The unprovoked invasion of Ukraine by Russia, the devastating earthquake in Turkey and Syria, and the ongoing conflicts in the Middle East are just a few examples. Millions of people have been killed or displaced, their futures uncertain. These events have resulted in extensive infrastructure collapse, with loss of electricity, transportation, and access to services. Schools, universities, and research centers have been destroyed along with decades' worth of data, samples, and findings. Scholars in disaster areas face short- and long-term problems in terms of what they can accomplish now for obtaining grants and for employment in the long run. In our interconnected world, conflicts and disasters are no longer a local problem but have wide-ranging impacts on the entire world, both now and in the future. Here, we focus on the current and ongoing impact of war on the scientific community within Ukraine and from this draw lessons that can be applied to all affected countries where scientists at risk are facing hardship. We present and classify examples of effective and feasible mechanisms used to support researchers in countries facing hardship and discuss how these can be implemented with help from the international scientific community and what more is desperately needed. Reaching out, providing accessible training opportunities, and developing collaborations should increase inclusion and connectivity, support scientific advancements within affected communities, and expedite postwar and disaster recovery.Article Iron-Promoted 1,5-Substitution Reaction of Endocyclic Enyne Oxiranes With Memgbr: a Stereoselective Method for the Synthesis of Exocyclic 2,4,5-Trienol Derivatives(MDPI, 2023) Kuş, Melih; Omur, Cenk; Karaca, Sila; Artok, LeventThe iron-promoted 1,5-substitution reaction of endocyclic oxiranes with MeMgBr yields exocyclic 2,4,5-trienols with high diastereomeric ratios of up to 100:0. However, for the method's success, the oxirane ring must have a trans-configuration. The reactions exhibit strong stereoselectivity concerning the methylation mode and the configuration of the resulting exocyclic double bond. Enantiomerically pure enyne oxiranes can be synthesized through Sharpless asymmetric dihydroxylation and subsequent manipulations. With these reagents, it has been possible to produce exocyclic 2,4,5-trienols in enantiopure forms. Importantly, this process maintains chirality without degradation during the center-to-axis transfer of chirality.Article Citation - WoS: 1Citation - Scopus: 1Light-Dark and Activity Rhythm Therapy (l-Dart) To Improve Sleep in People With Schizophrenia Spectrum Disorders: a Single-Group Mixed Methods Study of Feasibility, Acceptability and Adherence(MDPI, 2023) Faulkner, Sophie; Didikoğlu, Altuğ; Byrne, Rory; Drake, Richard; Bee, PennyPeople with a diagnosis of schizophrenia often have poor sleep, even when their psychotic symptoms are relatively well managed. This includes insomnia, sleep apnoea, hypersomnia, and irregular or non-24 h sleep-wake timing. Improving sleep would better support recovery, yet few evidence-based sleep treatments are offered to this group. This paper presents a mixed methods feasibility and acceptability study of Light-Dark and Activity Rhythm Therapy (L-DART). L-DART is delivered by an occupational therapist over 12 weeks. It is highly personalisable to sleep phenotypes and circumstances. Ten participants with schizophrenia spectrum diagnoses and sleep problems received L-DART; their sleep problems and therapy goals were diverse. We measured recruitment, attrition, session attendance, and adverse effects, and qualitatively explored acceptability, engagement, component delivery, adherence, activity patterns, dynamic light exposure, self-reported sleep, wellbeing, and functioning. Recruitment was ahead of target, there was no attrition, and all participants received the minimum 'dose' of sessions. Acceptability assessed via qualitative reports and satisfaction ratings was good. Adherence to individual intervention components varied, despite high participant motivation. All made some potentially helpful behaviour changes. Positive sleep and functioning outcomes were reported qualitatively as well as in outcome measures. The findings above support testing the intervention in a larger randomised trial ISRCTN11998005.Review Citation - WoS: 9Citation - Scopus: 12Readiness and Maturity Models for Industry 4.0: a Systematic Literature Review(John Wiley and Sons Ltd, 2023) Ünlü, H.; Demirörs, O.; Garousi, V.Industry 4.0 changes traditional manufacturing relationships from isolated optimized cells to fully integrated data and product flows across borders with its technological pillars. However, the transition to Industry 4.0 is not a straightforward journey in which organizations need assistance. A well-known approach that can be utilized during the early phases of the transition is to assess the capability of the organization. Maturity models are frequently used to improve capability. In this systematic literature review (SLR), we analyzed 22 maturity and readiness models based on 10 criteria: year, type, focus, structure, research methodology followed during the design of models, base frameworks, tool support, community support, objectivity, and extent of usage in practice. Our SLR provides a well-defined comparison for organizations to choose and apply available models. This SLR showed that (1) there is no widely accepted maturity/readiness model for Industry 4.0, as well as no international standard; (2) only a few models have received positive feedback from the industry, whereas most do not provide any practical usage information; and (3) the objectivity of the assessment method is controversial in most of the models. We have also identified a number of issues as open research areas for assessing readiness and maturity models for Industry 4.0. © 2023 John Wiley & Sons, Ltd.Article Citation - WoS: 13Citation - Scopus: 13On the Temperature Measurement During Ultrafast High-Temperature Sintering (uhs): Shall We Trust Metal-Shielded Thermocouples?(Elsevier Sci Ltd, 2024) Biesuz, Mattia; Karacasulu, Levent; Vakifahmetoglu, Cekdar; Sglavo, Vincenzo M.Temperature measurement upon ultrafast high-temperature sintering (UHS) is a crucial task. Herein, we provide some arguments posing concerns about the use of metal-shielded thermocouples as temperature probes in UHS. The discussion is based on literature data and on some ad hoc experiments. In detail, we show at least two cases in the literature where the use of a shielded thermocouple causes a substantial underestimation of the UHS temperature. The argumentation is based on comparing the thermocouples read and the observed phase and microstructural evolution. Moreover, by means of a simple experimental design, we show that a metal shield on the thermocouple tip can substantially reduce the measured temperature. Since the metal shield is orders of magnitude more thermally conductive than the graphite felt used as heating element in UHS, it efficiently removes heat from the thermocouple tip region. As such, data acquired from shielded thermocouples must be treated with care.Article Citation - WoS: 7Citation - Scopus: 8Lithium Extraction From Aqueous Systems by Λ-mno<sub>2</Sub>-deposited Pu Electrospun Mats(Amer Chemical Soc, 2023) Akgun, Berk; Baba, Alper; Demir, Mustafa M.There has been a strong increase in demand for lithium, so the extraction of lithium from natural water resources has become a remarkable remedy to reduce the harmful environmental impact of conventional lithium extraction processes. One of the most effective methods of separating lithium from natural water sources is adsorption using lithium ion sieves as adsorbents. However, the powdered nature of the adsorbents makes them challenging to process. In this study, flexible and free-standing polyurethane (PU) electrospun mats associated with lambda-MnO2 particles were fabricated to extract lithium from aqueous systems. Bead-free and smooth nanofibers were electrospun from a volumetric mixture of DMF:THF (1:2) at 30 wt % of PU solution. lambda-MnO2 powder was deposited on the electrospun mat by vacuum-assisted deposition. The lithium extraction performance of the mats was found to be 21% using single-layer filtration and increased to 77% with multistage filtration. Moreover, using the optimized conditions, lithium extraction achieved up to 14% in a spiked brine sample taken from Lake Tuz (Central Anatolia, Turkey), where the Mg2+/Li+ ratio is higher than 85.