WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

Permanent URI for this collectionhttps://hdl.handle.net/11147/7150

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Has files: YesPublisher: search.filters.publisher.Marmara Üniversitesi

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  • Article
    Citation - WoS: 1
    Investigation of Potential Anticarcinogenic Effects of Corilagin in Lung Cancer Cells
    (Marmara Üniversitesi, 2019) Rencüzoğulları, Çağla; Baran, Yusuf; İplik, Elif Sinem; Baran, Yusuf; Çakmakoğlu, Bedia; 04.03. Department of Molecular Biology and Genetics; 04. Faculty of Science; 01. Izmir Institute of Technology
    Objective: Lung cancer (LC) is the most extensive reason of cancer associated deaths in men and women in the world. LC categorizes into two main groups due to their molecular clinicopathological features and therapeutic responses. Non-small cell lung cancer (NSCLC) is the main subgroup that consists of nearly 85% of all lung cancer types. Corilagin, a biologically active ellagitannin, could be extracted from Phyllanthus species which are known as Chinese medicinal plant. It has been recently shown that Corilagin could exert anti-inflammatuar and antioxidative effects in different experimental cancer models. However, the molecular effects of Corilagin in NSCLC remain unclear. Methods: In this study, the antiproliferative and apoptotic effects of Corilagin were identified by WST-1 cell proliferation test, caspase-3 and mitochondrial membrane potential (MMP). Results: We found that Corilagin significiantly suppressed the proliferation of NSCLC cells. Furthermore, we also showed that Corilagin could contribute apoptosis by inducing activity of caspase-3 molecule and loss of MMP. Conclusion: Taken together, our study first showed that Corilagin could be a new treatment method for NSCLC after verifying its effects with in vivo and clinical studies.
  • Article
    Citation - WoS: 2
    Citation - Scopus: 2
    In Situ Production of Cationic Lipid Coated Magnetic Nanoparticles in Multiple Emulsions for Gene Delivery
    (Marmara Üniversitesi, 2016) Akbaba, Hasan; Selamet, Yusuf; Kantarcı, A. Gülten; 04.05. Department of Pyhsics; 04. Faculty of Science; 01. Izmir Institute of Technology
    Magnetic nanoparticles are effective delivery systems to target therapeutic genes by the attractive forces of magnetic fields. Curative effects depending on dose of nucleic acids or drugs increased, while cytotoxic effects minimized with these systems. In this study, a novel magnetic nanoparticle synthesis method was developed by combining advantages of microemulsion and multiple emulsion methods. Particle size, zeta potential, magnetization, complex formation with nucleic acids, DNase I protection ability, and cytotoxicity levels were examined. At last, magnetic nanoparticles were obtained with a promising synthesis method and it is determined that they are sufficiently small, non-toxic and have optimal surface properties for systemic delivery of nucleic acids.