WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

Permanent URI for this collectionhttps://hdl.handle.net/11147/7150

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Institution Author: search.filters.institutionAuthor.Bayraktar, OğuzPublisher: search.filters.publisher.Elsevier

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Now showing 1 - 4 of 4
  • Article
    Optimization of Extraction for Antioxidant and Photoprotective Bioactive Compounds From Ulva Rigida
    (Elsevier, 2025) Bayraktar, Oğuz; Bicakci, Beyza Tutku; Erdem, Cansu; Sincar, Bahar; Ozdemir, Feyza; Keskin, Melike; Bayraktar, Oguz; 01. Izmir Institute of Technology; 03. Faculty of Engineering; 03.02. Department of Chemical Engineering
    This study presents the development and optimization of a green extraction bioprocess for Ulva rigida, aiming to efficiently recover bioactive compounds with antioxidant and photoprotective properties using response surface methodology (RSM). A Box-Behnken design evaluated the combined effects of ethanol concentration (0-100 %), solid-to-liquid ratio (20-40 mL g-1), and extraction time (8-24 h) on extraction yield, antioxidant capacity, and sun protection factor (SPF). All variables significantly impacted extract quality, with ethanol concentration being the most influential. Optimal conditions (100 % ethanol, 1:20 ratio, 16 h) yielded an extract with SPF 11.61 and antioxidant activity of 16.91 mg Trolox/g. Preparative thin-layer chromatography (TLC) of the optimized extract produced three bioactive fractions exhibiting up to 2.3-fold higher SPF and 5-fold greater antioxidant activity. Liquid chromatography-mass spectrometry (LC-MS) analysis confirmed selective enrichment of carotenoids and polyphenols. These findings demonstrate the value of statistically optimized, bioactivity-guided extraction in enhancing Ulva-derived ingredients for cosmeceutical use.
  • Conference Object
    Citation - WoS: 2
    Incorporation of Equisetum Arvense Extract Into Silk Fibroin-Hyaluronic Acid Sponge Matrices for Wound Dressing Applications
    (Elsevier, 2012) Uslu, Mehmet Emin; Erdoğan, İpek; Erdoğan, İpek; Bayraktar, Oğuz; Bayraktar, Oğuz; 04.03. Department of Molecular Biology and Genetics; 03.02. Department of Chemical Engineering; 03. Faculty of Engineering; 04. Faculty of Science; 01. Izmir Institute of Technology
    Equisetum arvense extract has frequently been investigated for its antioxidant capacity, antimicrobial and antitumor properties. However, one of the challenges in natural compound investi-gations is to maintain the stability of polyphenolic compounds during their storage and applications. For this purpose extracts can be incorporated into different forms of biomaterial. In this research silk fibroin (SF) and hyaluronic acid (HA) was used as sponge matri-ces for wound dressing application.
  • Conference Object
    In Vitro Antitumor Activity of Sarcopoterium Spinosum Leaf Extract With Bioactive Natural Compounds
    (Elsevier, 2013) Süngüç, Ceren; Bayraktar, Oğuz; Erdoğan, İpek; Erdoğan, İpek; Uslu, Mehmet Emin; Bayraktar, Oğuz; 04.03. Department of Molecular Biology and Genetics; 03.02. Department of Chemical Engineering; 03. Faculty of Engineering; 04. Faculty of Science; 01. Izmir Institute of Technology
    Cancer cell lines cause generation of reactive oxygen species and free radicals at high levels (Wang and Yi, 2008). Then generated free radicals lead to breakdown of the structure of DNA, lipid or protein (Gul et al., 2011). When plant extracts including antioxidant phytochemicals are exposed to the redox reactions, the harmful effects of free radicals are effectively prevented. The aim of present research was to evaluate the antitumor potential of the extract derived from Sarcopoterium spinosum leaves. The leaves of S. spinosum were collected in Izmir, Turkey. Total phenol content of ethanolic.
  • Conference Object
    Investigation of Anti-Tumoral Activity of Cistus Creticus Extract Against Pc-3 Cell Line
    (Elsevier, 2013) Erdoğan, İpek; Bayraktar, Oğuz; Süngüç, Ceren; Erdoğan, İpek; Uslu, Mehmet Emin; Bayraktar, Oğuz; 04.03. Department of Molecular Biology and Genetics; 03.02. Department of Chemical Engineering; 03. Faculty of Engineering; 04. Faculty of Science; 01. Izmir Institute of Technology
    Recent studies have revealed that plant extracts show cytotoxic activities against cancer cell lines by ceasing cell division in particular phases (Xu et al., 2012, Yıldırım et al., 2013). Expression of specific genes was found to be activated according to pathway in which cell death occurs. Objective of this study was to identify antitumoural effect of Cistus creticus, which is a perennial shrub, found in Mediterranean region, against prostate cancer cell line by measuring the cytotoxic activities and apoptotic gene expression levels.