WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
Permanent URI for this collectionhttps://hdl.handle.net/11147/7150
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Conference Object Nilotinib Significantly Induces Apoptosis in Imatinib Resistant K562 Cells, as Effectively as in Parental Sensitive Counterparts(Ferrata Storti Foundation, 2009) Baran, Yusuf; Can, Geylani; Ekiz, Hüseyin Atakan[No abstract available]Conference Object Imatinib Induces Autophagy Through Increasing the Expression Levels of Beclin-1 and Atg-5 Genes in Both Parental Sensitive and Imatinib-Resistant K562 Cells(Ferrata Storti Foundation, 2009) Baran, Yusuf; Can, Geylani; Ekiz, Hüseyin Atakan; Genç, S. G.[No abstract available]Conference Object Expression Analysis of 84 Genes Involved in Different Signalling Pathways of Cancer in Chronic Myeloid Leukemia Cells in Response To Nilotinib(Ferrata Storti Foundation, 2010) Baran, Yusuf; Camgöz, Aylin; Can, Geylani[No abstract available]Conference Object Gene Expression Profiles in Resveratrol Applied Acute Promyelocytic Leukemia Cells(Ferrata Storti Foundation, 2010) Baran, Yusuf; Çakır, Zeynep; Can, Geylani; Saydam, Güray; Şahin, Fahri[No abstract available]Conference Object Apoptotic Effects of Resveratrol on Imatinib Sensitive and Resistant K562 Chronic Myeloid Leukemia Cells(Ferrata Storti Foundation, 2010) Baran, Yusuf; Can, Geylani[No abstract available]Conference Object Cytotoxic Effects of Resveratrol on Imatinib Sensitive and Resistant K562 Chronic Myeloid Leukemia Cells(Pergamon-Elsevier Science Ltd, 2010) Can, G.; Baran, Y.Conference Object Therapeutic Potential of Targeting Sphingolipid Signaling Pathways in Various Types of Cancers(Pergamon-elsevier Science Ltd, 2010) Baran, Y.; Bassoy, E. Y.; Cakir, Z.; Camgoz, A.; Gencer, E. B.; Kartal, M.; Gucluler, G.Conference Object Changes in Expression Profiles of Apoptosis, Invasion, Metastasis, Angiogenesis, Transcription Factors, Cell Cycle Control and Tumour Supressor Genes in Nilotinib Treated Chronic Myeloid Leukemia Cells(Pergamon-elsevier Science Ltd, 2010) Baran, Y.; Camgoz, A.; Can, G.Conference Object Gene Expression Profiles in Resveratrol-Induced Cell Death in Acute Promyelocytic Leukemia Cells(Elsevier Ltd., 2010) Çakır, Zeynep; Can, Geylani; Saydam, Güray; Şahin, Fahri; Baran, Yusuf[No abstract available]Article Citation - WoS: 20Apoptotic Effects of Resveratrol, a Grape Polyphenol, on Imatinib-Sensitive and Resistant K562 Chronic Myeloid Leukemia Cells(International Institute of Anticancer Research, 2012) Can, Geylani; Çakır, Zeynep; Kartal, Melis; Gündüz, Ufuk; Baran, YusufTo examine the antiproliferative and apoptotic effects of resveratrol on imatinib-sensitive and imatinib-resistant K562 chronic myeloid leukemia cells. Antiproliferative effects of resveratrol were determined by the 3-Bis[2-methoxy-4-nitro-5-sulphophenyl]-2H-tetrazolium-5-carboxanilide inner salt (XTT) cell proliferation assay. Apoptotic effects of resveratrol on sensitive K562 and resistant K562/IMA-3 cells were determined through changes in caspase-3 activity, loss of mitochondrial membrane potential (MMP), and apoptosis by annexin V-(FITC). The concentrations of resveratrol that inhibited cell growth by 50% (IC(50)) were calculated as 85 and 122 μM for K562 and K562/IMA-3 cells, respectively. There were 1.91-, 7.42- and 14.73-fold increases in loss of MMP in K562 cells treated with 10, 50, and 100 μM resveratrol, respectively. The same concentrations of resveratrol resulted in 2.21-, 3.30- and 7.65-fold increases in loss of MMP in K562/IMA-3 cells. Caspase-3 activity increased 1.04-, 2.77- and 4.8-fold in K562 and 1.02-, 1.41- and 3.46-fold in K562/IMA-3 cells in response to the same concentrations of resveratrol, respectively. Apoptosis was induced in 58.7%- and 43.3% of K562 and K562/IMA-3 cells, respectively, in response to 100 μM resveratrol. Taken together these results may suggest potential use of resveratrol in CML, as well as in patients with primary and/or acquired resistance to imatinib.