WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

Permanent URI for this collectionhttps://hdl.handle.net/11147/7150

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Institution Author: search.filters.institutionAuthor.Yaşar Mahlıçlı, FilizSubject: search.filters.subject.Hemodialysis membranes

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Now showing 1 - 4 of 4
  • Article
    Citation - WoS: 31
    Citation - Scopus: 32
    Immobilization of Alpha Lipoic Acid Onto Polysulfone Membranes To Suppress Hemodialysis Induced Oxidative Stress
    (Elsevier Ltd., 2014) Yaşar Mahlıçlı, Filiz; Alsoy Altınkaya, Sacide; Alsoy Altınkaya, Sacide; 03.02. Department of Chemical Engineering; 03. Faculty of Engineering; 01. Izmir Institute of Technology
    Alpha-lipoic acid (ALA) immobilized polysulfone (PSF) hemodialysis membranes have been fabricated by the dry-wet phase inversion technique. The antioxidant properties of the membranes were evaluated in terms of inhibition of reactive oxygen species (ROS) in blood plasma, while their blood compatibilities were determined by quantitating plasma protein adsorption, platelet adhesion, activation and cytotoxicity to blood cells. The stability of ALA under typical hemodialysis conditions was improved by immobilization, and the greatest enhancement was achieved when it was sandwiched between two polyethyleneimine (PEI) layers. In vitro antioxidant activity measurements showed that ALA coated membranes are not only capable of reducing ROS levels in blood, protein adsorption and platelet activation on the membranes, but, can also prolong coagulation time. All membranes prepared were noncytotoxic to peripheral blood mononuclear cells. In addition, the high permeation rates of solutes through PSF membrane were not affected by ALA immobilization.
  • Article
    Citation - WoS: 29
    Citation - Scopus: 33
    Surface Modification of Polysulfone Based Hemodialysis Membranes With Layer by Layer Self Assembly of Polyethyleneimine/Alginate-heparin: a Simple Polyelectrolyte Blend Approach for Heparin Immobilization
    (Springer Verlag, 2013) Yaşar Mahlıçlı, Filiz; Alsoy Altınkaya, Sacide; Alsoy Altınkaya, Sacide; 03.02. Department of Chemical Engineering; 03. Faculty of Engineering; 01. Izmir Institute of Technology
    This study intends to improve blood compatibility of polysulfone (PSF) membranes by generating a nonthrombogenic surface through heparin immobilization. To achieve this task, the support membrane prepared from a blend of PSF and sulfonated polysulfone (SPSF) was modified with layer by layer (LBL) deposition of polyethyleneimine (PEI) and alginate (ALG) and heparin blended with ALG was immobilized only on the outermost surface of the LBL assembly. The results have shown that the adsorption of human plasma proteins and platelet activation on the LBL modified membranes decreased significantly compared with the unmodified PSF and PSF-SPSF blend membranes. Furthermore, blending ALG with a small amount of heparin remarkably prolonged the APTT values of heparin free PEI/ALG coated membranes. It is envisaged that the use of a blend of HEP and ALG only in the terminating layer of the LBL assembly can be an economical and alternative modification technique to create nonthrombogenic surfaces.
  • Conference Object
    Citation - Scopus: 3
    Characterization of Polysulfone Based Hemodialysis Membranes by Afm
    (Elsevier Ltd., 2012) Uz, Metin; Yaşar Mahlıçlı, Filiz; Alsoy Altınkaya, Sacide; Alsoy Altınkaya, Sacide; Polat, Mehmet; 03.02. Department of Chemical Engineering; 03. Faculty of Engineering; 01. Izmir Institute of Technology
    Most of the hemodialysis membrane materials are hydrophobic in nature and allow protein adsorption on the surface easily due to hydrophobic interaction between membrane surface and protein molecules when in contact with blood. Adsorbed proteins can affect platelet and leukocyte adhesion, and modulate the response of plasmatic reactions followed by the activation of different defense systems in blood (Sun et al. 2003).
  • Article
    Citation - WoS: 8
    Citation - Scopus: 8
    The Effects of Urease Immobilization on the Transport Characteristics and Protein Adsorption Capacity of Cellulose Acetate Based Hemodialysis Membranes
    (Springer Verlag, 2009) Yaşar Mahlıçlı, Filiz; Alsoy Altınkaya, Sacide; Alsoy Altınkaya, Sacide; 03.02. Department of Chemical Engineering; 03. Faculty of Engineering; 01. Izmir Institute of Technology
    In this study, cellulose acetate (CA) based hemodialysis membranes were prepared by a dry phase inversion method and the influences of urease immobilization on the clearing performance and protein adsorption capacity of the membranes were investigated. Permeation experiments have shown that modification of CA membranes with urease immobilization not only enhanced the transport rate of urea but also increased the permeation coefficients of uric acid and creatinine by changing the structure of the membrane. Furthermore, the protein adsorption capacity of the CA membranes decreased. On the other hand, the mechanical strength of the modified CA membrane did not change significantly compared with that of the unmodified one. A mathematical model was derived to determine the rate of mass transfer of urea through modified CA membranes. Model predictions along with the experimental data suggest that urease immobilization can be used as an alternative method in preparing CA based hemodialysis membranes with improved transport characteristics and biocompatibility through reduced protein adsorption capacities.