WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
Permanent URI for this collectionhttps://hdl.handle.net/11147/7150
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Article Citation - WoS: 2Citation - Scopus: 3Unlocking the Biological Potential of Emulsion-Templated Matrices Through Surface Engineering for Biomedical Applications(Elsevier Sci Ltd, 2025) Sert, Emircan; Aldemir Dikici, Betül; Ozmen, Ece; Owen, Robert; Dikici, Betul Aldemir; 03.01. Department of Bioengineering; 03. Faculty of Engineering; 01. Izmir Institute of TechnologyEmulsion templating is a highly advantageous route for the fabrication of porous materials, enabling the development of matrices with high porosity, high interconnectivity, and precise morphological control. Synthetic polymers are most widely used in the fabrication of emulsion-templated tissue engineering scaffolds due to their superior mechanical strength, ease of fabrication, control over polymer properties, and batch-to-batch stability. The biological response is strongly associated with the surface properties of the biomaterials; however, scaffolds constructed from synthetic polymers often lack cell recognition sites and exhibit limited bioactivity. Thus, synthetic polymer-based porous matrices commonly require surface post-modification to improve cell adhesion, proliferation, migration, gene expression, and differentiation processes. To date, extensive work has been carried out investigating surface modification of scaffolds fabricated via traditional scaffold fabrication techniques. Still, studies addressing the post-modification of emulsion-templated matrices are comparatively limited despite an exponential increase in the number of publications on emulsion templating for tissue engineering in recent years. This review will first examine the fundamentals of emulsion templating, then describe cell adhesion and the characteristics of scaffolds that influence cell-material interactions. It will then provide a comprehensive analysis of surface modification techniques and recent advancements in surface-modified emulsion-templated matrices for tissue engineering applications. Finally, we address the challenges and future directions in this rapidly evolving field. We anticipate that this comprehensive literature review will present the current state-of-the-art and serve as a valuable roadmap for researchers seeking to enhance the biological performance of their emulsion-templated scaffolds through surface modifications. Such scaffold optimisation strategies not only improve cell-material interactions but also hold translational potential for advancing human healthcare through more effective regenerative therapies.Article Citation - WoS: 4Citation - Scopus: 4Surface Modification Via Alkali Treatment and Its Effect on the Physicochemical and Biological Properties of Emulsion Templated Scaffolds(Elsevier Sci Ltd, 2025) Aldemir Dikici, Betül; Tıhmınlıoğlu, Funda; Dikici, Betul Aldemir; 03.02. Department of Chemical Engineering; 03.01. Department of Bioengineering; 03. Faculty of Engineering; 01. Izmir Institute of TechnologyEmulsion templating is an advantageous scaffold fabrication technique that provides high interconnectivity, high porosity, and control of the scaffold architecture. Polymerised emulsions with an internal phase ratio greater than 74 % are named Polymerised High Internal Phase Emulsions (PolyHIPEs). Polycaprolactone (PCL) is a synthetic, biodegradable, and biocompatible polymer widely used in tissue engineering, but the material-cell interaction of PCL-based biomaterials has been found to be limited due to the material's high hydrophobicity. This study aims to develop emulsion-templated polycaprolactone tetramethacrylate (4PCLMA)-based scaffolds and improve their biological performance using an alkaline surface modification method. For this purpose, 4PCLMA was successfully synthesised, and highly porous scaffolds were developed. PolyHIPEs were incubated in three different sodium hydroxide (NaOH) concentrations for three different incubation times. Chemical, morphological, mechanical characterisation, mass loss, water absorption capacity, water contact angle, Brunauer-Emmett-Teller analyses and biological investigations were conducted on NaOH-treated scaffolds in comparison with the control. The chemical changes induced by NaOH treatment in PolyHIPEs were confirmed by Fourier-transform infrared spectroscopy. NaOH treatment increased the water absorption capacity, hydrophilicity, surface area, and protein adsorption but decreased the weight and mechanical strength of the scaffolds. In vitro results showed that NaOH treatment did not cause cytotoxicity in L929 cells and positively affected the cell adhesion and proliferation behaviour of Saos-2 cells. This study suggests surface modification of biodegradable synthetic polymer-based PolyHIPEs by NaOH treatment as a simple, scalable and cost-effective approach to enhance cell-material interactions of the material without causing a significant change in the overall morphology, contributing to the advancement of next-generation healthcare technologies.Article Citation - WoS: 18Citation - Scopus: 17Modifying Pickering Polymerized High Internal Phase Emulsion Morphology by Adjusting Particle Hydrophilicity(Elsevier, 2024) Durgut, Enes; Aldemir Dikici, Betül; Dikici, Betuel Aldemir; Foudazi, Reza; Claeyssens, Frederik; 03.01. Department of Bioengineering; 03. Faculty of Engineering; 01. Izmir Institute of TechnologyThis study investigates the use of submicron polymeric particles with varying crosslinking densities as the sole stabilizer for producing Polymerized High Internal Phase Emulsions (PolyHIPE). We establish a direct correlation between the crosslinking density and the hydrophilicity of the polymer particles. The hydrophilicity of these particles significantly influences the morphology and rheology of HIPEs. These differences manifest as various morphological variations in the resulting PolyHIPE templates. It was discovered that by increasing the crosslinker weight percentage in the particles from 0 % to 100 %, PolyHIPEs with semi-open, open, and closed porous structures can be obtained. Furthermore, non-crosslinked particles were observed to dissolve in the continuous phase, acting as macromolecular surfactants that generate small pores akin to surfactant-stabilized structures in PolyHIPE. These findings offer fresh insights into the relationship between particle localization at the interface, HIPE rheology, and the formation of pore throats in Pickering PolyHIPEs, leading to the creation of either closed or open porous networks. Additionally, interfacial rheological results demonstrate that particles synthesized with varying monomer-to-crosslinker ratios exhibit different interfacial elasticities, which are linked to PolyHIPE morphology.