WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
Permanent URI for this collectionhttps://hdl.handle.net/11147/7150
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Article Citation - WoS: 5Citation - Scopus: 4Identifying Factors Controlling Cellular Uptake of Gold Nanoparticles by Machine Learning(TAYLOR & FRANCIS LTD, 2023) Bilgi, Eyüp; Bilgi, Eyüp; Öksel Karakuş, Ceyda; 03.01. Department of Bioengineering; 03. Faculty of Engineering; 01. Izmir Institute of TechnologyThere is strong interest to improve the therapeutic potential of gold nanoparticles (GNPs) while ensuring their safe development. The utility of GNPs in medicine requires a molecular-level understanding of how GNPs interact with biological systems. Despite considerable research efforts devoted to monitoring the internalisation of GNPs, there is still insufficient understanding of the factors responsible for the variability in GNP uptake in different cell types. Data-driven models are useful for identifying the sources of this variability. Here, we trained multiple machine learning models on 2077 data points for 193 individual nanoparticles from 59 independent studies to predict cellular uptake level of GNPs and compared different algorithms for their efficacies of prediction. The five ensemble learners (Xgboost, random forest, bootstrap aggregation, gradient boosting, light gradient boosting machine) made the best predictions of GNP uptake, accounting for 80-90% of the variance in the test data. The models identified particle size, zeta potential, GNP concentration and exposure duration as the most important drivers of cellular uptake. We expect this proof-of-concept study will foster the more effective use of accumulated cellular uptake data for GNPs and minimise any methodological bias in individual studies that may lead to under- or over-estimation of cellular internalisation rates.Article Citation - WoS: 9Citation - Scopus: 11Prediction of Vinegar Processing Parameters With Chemometric Modelling of Spectroscopic Data(Elsevier, 2021) Çavdaroğlu, Çağrı; Özen, Fatma Banu; Özen, Banu; Özen, Fatma Banu; 03.08. Department of Food Engineering; 01. Izmir Institute of Technology; 03. Faculty of EngineeringSpectroscopic methods have the advantages of being rapid and environmentally friendly and can be used in measurement and control of processing parameters during food production. It was aimed to predict several quality and chemical parameters of vinegar processing from UV-visible and mid-infrared spectroscopic profiles. Two processing lines of both traditional and submerged vinegar production from 2 separate grape varieties (green and red grapes) were monitored. Some of the important markers of the fermentation processes; pH, brix, total acidity, total flavonoid content, total and individual phenolic contents, organic acid, sugar, ethanol concentrations as well as UV-visible and mid-infrared spectra were obtained during both types of vinegar processing and quality and chemical parameters were predicted from spectroscopic data using chemometric methods. Individual UV-visible and mid-infrared spectral profiles along with low level of data fusion were used in building of chemometric prediction models. Accurate, reliable and robust prediction models (R(2)cal and R(2)val >0.9) were obtained for quality parameters mostly with combination of two spectroscopic datasets. Predictive models used for phenolic components were below average except for p-coumaric and syringic acids. Citric and acetic acids were the most accurately estimated ones among organic acids along with ethanol. Close agreements between reference and predicted values were obtained during the monitoring of changes of some quality parameters for vinegar fermentation process through rapid and simultaneous spectroscopic measurements.Article Citation - WoS: 5Citation - Scopus: 7Experimental and Modeling Study of Strength of High Strength Concrete Containing Binary and Ternary Binders(Foundation Cement, Lime, Concrete, 2011) Erdem, Tahir Kemal; Erdem, Tahir Kemal; Kırca, Önder; Tayfur, Gökmen; 03.03. Department of Civil Engineering; 03. Faculty of Engineering; 01. Izmir Institute of TechnologySilica fume (SF), fl y ash (FA) and ground granulated blastfurnace slag (S) are among the most widely utilized mineral additions for normal strength concrete (NSC) and high strength concrete (HSC). High Reactivity Metakaolin (HRMK) is a relatively new mineral addition, produced by calcination of highly pure kaolin. The replacement of cement with HRMK increases the strength, especially at early ages, and improves durability of concrete. (1-3). Pumice (P) is a porous volcanic glass containing 60-75 SiO2% and 13-17% Al2O3. When fi nely ground, it shows pozzolanic characteristics but it is generally used as a lightweight aggregate in the concrete industry (4, 5). HRMK and P have white color and, therefore, are useful for production of white concrete when applied with white Portland cement (WPC)Article Citation - WoS: 96Citation - Scopus: 105Comparative Study of a Building Energy Performance Software (kep-Iyte and Ann-Based Building Heat Load Estimation(Elsevier Ltd., 2014) Turhan, Cihan; Kazanasmaz, Zehra Tuğçe; Kazanasmaz, Zehra Tuğçe; Turhan, Cihan; Erlalelitepe Uygun, İlknur; Gökçen Akkurt, Gülden; Ekmen, Kenan Evren; Gökçen Akkurt, Gülden; 02.02. Department of Architecture; 03.10. Department of Mechanical Engineering; 03.06. Department of Energy Systems Engineering; 03. Faculty of Engineering; 01. Izmir Institute of Technology; 02. Faculty of ArchitectureThe several parameters affect the heat load of a building; geometry, construction, layout, climate and the users. These parameters are complex and interrelated. Comprehensive models are needed to understand relationships among the parameters that can handle non-linearities. The aim of this study is to predict heat load of existing buildings benefiting from width/length ratio, wall overall heat transfer coefficient, area/volume ratio, total external surface area, total window area/total external surface area ratio by using artificial neural networks and compare the results with a building energy simulation tool called KEP-IYTE-ESS developed by Izmir Institute of Technology. A back propagation neural network algorithm has been preferred and both simulation tools were applied to 148 residential buildings selected from 3 municipalities of Izmir-Turkey. Under the given conditions, a good coherence was observed between artificial neural network and building energy simulation tool results with a mean absolute percentage error of 5.06% and successful prediction rate of 0.977. The advantages of ANN model over the energy simulation software are observed as the simplicity, the speed of calculation and learning from the limited data sets.Article Citation - WoS: 35Citation - Scopus: 36Coupling Soil Moisture and Precipitation Observations for Predicting Hourly Runoff at Small Catchment Scale(Elsevier Ltd., 2014) Tayfur, Gökmen; Tayfur, Gökmen; Brocca, Luca; Moramarco, Tommaso; 03.03. Department of Civil Engineering; 03. Faculty of Engineering; 01. Izmir Institute of TechnologyThe importance of soil moisture is recognized in rainfall-runoff processes. This study quantitatively investigates the use of soil moisture measured at 10, 20, and 40cm soil depths along with rainfall in predicting runoff. For this purpose, two small sub-catchments of Tiber River Basin, in Italy, were instrumented during periods of October 2002-March 2003 and January-April 2004. Colorso Basin is about 13km2 and Niccone basin 137km2. Rainfall plus soil moisture at 10, 20, and 40cm formed the input vector while the discharge was the target output in the model of generalized regression neural network (GRNN). The model for each basin was calibrated and tested using October 2002-March 2003 data. The calibrated and tested GRNN was then employed to predict runoff for each basin for the period of January-April 2004. The model performance was found to be satisfactory with determination coefficient, R2, equal to 0.87 and Nash-Sutcliffe efficiency, NS, equal to 0.86 in the validation phase for both catchments. The investigation of effects of soil moisture on runoff prediction revealed that the addition of soil moisture data, along with rainfall, tremendously improves the performance of the model. The sensitivity analysis indicated that the use of soil moisture data at different depths allows to preserve the memory of the system thus having a similar effect of employing the past values of rainfall, but with improved GRNN performance.