WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
Permanent URI for this collectionhttps://hdl.handle.net/11147/7150
Browse
38 results
Search Results
Correction Diaph1-Deficiency Is Associated With Major T, Nk and Ilc Defects in Humans (vol 44, 175, 2024)(Springer/plenum Publishers, 2025) Azizoglu, Zehra Busra; Babayeva, Royala; Haskologlu, Zehra Sule; Acar, Mustafa Burak; Ayaz-Guner, Serife; Okus, Fatma Zehra; Eken, Ahmet[No Abstract Available]Article An Interior Inverse Generalized Impedance Problem for the Modified Helmholtz Equation in Two Dimensions(Wiley-v C H verlag Gmbh, 2025) Yaman, Olha Ivanyshyn; Ozdemir, GaziWe consider the inverse interior problem of recovering the surface impedances of the cavity from sources and measurements placed on a curve inside of it. The uniqueness issue is investigated, and a hybrid method is proposed for the numerical solution. The approach takes advantages of both direct and iterative schemes, such as it does not require an initial guess and has an accuracy of a Newton-type method. Presented numerical experiments demonstrate the feasibility and effectiveness of the approach.Article Citation - WoS: 2Citation - Scopus: 2Stabilization of the First-Order Phase Transition Character and Enhancement of the Electrocaloric Effect by Na<sub>0.5</Sub>bi<sub>0.5< Substitution in Batio<sub>3</Sub> Ceramics(Royal Soc Chemistry, 2024) Karakaya, Merve; Gurbuz, Irem; Fulanovic, Lovro; Adem, UmutThe electrocaloric properties of BaTiO3-based Pb-free ferroelectric materials are widely investigated. One approach to achieving a large electrocaloric response is making use of the substantial polarization change associated with the first-order phase transition at the Curie temperature. To make use of this approach, we have investigated the electrocaloric response of (1 - x)BaTiO3-xNa0.5Bi0.5TiO3 (BT-NBT) ceramics for x = 0.05, 0.10, 0.20 and 0.30. For this BT-rich part of the solid solution, it is established that increasing the NBT content increases the tetragonality of the BaTiO3. We show that this increase in tetragonality with NBT substitution helps to maintain the first-order nature of the phase transition in BaTiO3 and correspondingly a large electrocaloric response, despite the simultaneous enhancement of relaxor ferroelectric character with the NBT substitution. A significantly larger effective electrocaloric temperature change (Delta Teff) of 1.65 K was obtained for the x = 0.20 sample under 40 kV cm-1, using the direct measurement of the electrocaloric effect, which is in reasonable agreement with the indirect measurements.Article Citation - WoS: 2Citation - Scopus: 1Gliflozins, Sucrose and Flavonoids Are Allosteric Activators of Lecithin-Cholesterol Acyltransferase(Nature Portfolio, 2024) Niemela, Akseli; Giorgi, Laura; Nouri, Sirine; Yurttas, Betul; Rauniyar, Khushbu; Jeltsch, Michael; Koivuniemi, ArtturiLecithin-cholesterol acyltransferase (LCAT) serves as a pivotal enzyme in preserving cholesterol homeostasis via reverse cholesterol transport, a process closely associated with the onset of atherosclerosis. Impaired LCAT function can lead to severe LCAT deficiency disorders for which no pharmacological treatment exists. LCAT-based therapies, such as small molecule positive allosteric modulators (PAMs), against LCAT deficiencies and atherosclerosis hold promise, although their efficacy against atherosclerosis remains challenging. Herein we utilized a quantitative in silico metric to predict the activity of novel PAMs and tested their potencies with in vitro enzymatic assays. As predicted, sodium-glucose cotransporter 2 (SGLT2) inhibitors (gliflozins), sucrose and flavonoids activate LCAT. This has intriguing implications for the mechanism of action of gliflozins, which are commonly used in the treatment of type 2 diabetes, and for the endogenous activation of LCAT. Our results underscore the potential of molecular dynamics simulations in rational drug design.Article Citation - WoS: 5Citation - Scopus: 5An Experimental and Comparative Study on Passive and Active Pcm Cooling of a Battery With/Out Copper Mesh and Investigation of Pcm Mixtures(Elsevier, 2024) Samancioglu, Umut Ege; Gocmen, Sinan; Madani, Seyed Saeed; Ziebert, Carlos; Nuno, Fernando; Huang, Jack; Cetkin, ErdalThe carbon emission contribution to global warming accelerated both research on and transition to electric vehicles (EVs). Drivers demand high power, fast acceleration and less charging times. All these demands require high C rate charging/discharging demands from batteries. The rate of heat generation is exponentially proportional to C rates which decreases battery lifetime and may lead to thermal runaway. However, a battery thermal management system decreases thermal runaway risk and decelerates battery degradation via controlling battery temperature. In this paper, we first document the thermal conductivity enhancement via copper foam into phase change material (PCM) domain to uncover their possible use in EV thermal management applications. Maximum 15.93 times increment is achieved with a specific copper foam. Then, physical properties and behaviors of distinct PCM mixtures are documented. Homogeneity of mixtures is associated with the chemistry of PCMs and the mixture melting point is proportional to the volume weighted average of melting temperatures. The results document that the PCM with relatively lower melting point is beneficial when end of discharge temperatures considered, except for high discharge rate of 2C. Temperature uniformity across the battery increases with relatively higher melting point PCM. Experiments also document that the amount of PCM volume lost via insertion of copper foam yields higher end of discharge temperatures. Overall, both PCM and copper foam enhances temperature homogeneity and their benefit becomes more sensible during drive cycles relative to continuous charge/discharge use cases.Conference Object Differential Susceptibility To Senescence in Cart Cells Based on Co-Stimulatory Signaling(Cell Press, 2024) Can, Ismail; Sakemura, Leo R.; Roman, Claudia Manriquez; Sirpilla, Olivia; Stewart, Carli; Yun, Kun; Kenderian, Saad[No Abstract Available]Article Citation - WoS: 3Citation - Scopus: 2Environmental Assessment of the Hydrogen Combustion Process in Non-Premixed Gas Turbines(Pergamon-elsevier Science Ltd, 2024) Sarialtin, Huseyin; Korucu, AyseUsing cleaner fuels, such as hydrogen and developing more efficient combustion technologies are crucial in reducing NOx and N2O emissions, contributing to environmental concerns like air pollution and global warming. However, studies focusing on gas turbines using H-2 as fuel often overlook the emissions resulting from H-2 combustion. Given that gas turbines play a significant role in electricity generation globally, even minor improvements in their efficiency can lead to substantial cumulative benefits. Therefore, this study aims to address this gap by conducting a comprehensive environmental assessment using the life cycle assessment (LCA) methodology. By evaluating the environmental impacts of emissions from the combustion process of a conventional gas turbine and comparing them with potential emissions from H(2)combustion, this research seeks to provide valuable insights into the overall environmental performance of these technologies and contribute to sustainable energy development efforts. There have already been several LCA studies on H-2 production. In this study, we have identified the potential emissions and environmental impacts of H-2 combustion in gas turbines and compared them with the impact values of H-2 production regarding reference studies. The result shows that emissions during combustion should be considered in the identified life cycle impact categories.Editorial Citation - WoS: 5Citation - Scopus: 5Rna M<sup>6</Sup>a Methylation at the Juxtaposition of Apoptosis and Rna Therapeutics(Cell Press, 2024) Akguel, Buenyamin; Akcaoez-Alasar, Azime; Saglam, BuketTargeting RNA m(6)A marks in apoptosis-related transcripts holds promise for RNA therapeutics. However, pathway-specific RNA m(6)A sites on pro- or antiapoptotic transcripts have not been fully unveiled, let alone characterized. This article summarizes the current knowledge and gaps in the cellular response modulated by apoptotic stimulus-specific RNA m(6)A marks.Article Citation - WoS: 9Citation - Scopus: 6Fluorescence Lifetime Multiplexing With Fluorogen Activating Protein Fast Variants(Nature Portfolio, 2024) Bogdanova, Yulia A.; Solovyev, Ilya D.; Baleeva, Nadezhda S.; Myasnyanko, Ivan N.; Gorshkova, Anastasia A.; Gorbachev, Dmitriy A.; Baranov, Mikhail S.In this paper, we propose a fluorescence-lifetime imaging microscopy (FLIM) multiplexing system based on the fluorogen-activating protein FAST. This genetically encoded fluorescent labeling platform employs FAST mutants that activate the same fluorogen but provide different fluorescence lifetimes for each specific protein-dye pair. All the proposed probes with varying lifetimes possess nearly identical and the smallest-in-class size, along with quite similar steady-state optical properties. In live mammalian cells, we target these chemogenetic tags to two intracellular structures simultaneously, where their fluorescence signals are clearly distinguished by FLIM. Due to the unique structure of certain fluorogens under study, their complexes with FAST mutants display a monophasic fluorescence decay, which may facilitate enhanced multiplexing efficiency by reducing signal cross-talks and providing optimal prerequisites for signal separation upon co-localized and/or spatially overlapped labeling. A genetically encoded labeling system uses smallest-in-class fluorogen-activating protein tags for time-resolved fluorescence multiplexed cellular imaging, offering monoexponential decay and potential for sophisticated fluorescence lifetime analysis.Article Citation - WoS: 6Citation - Scopus: 6Tumour-Intrinsic Endomembrane Trafficking by Arf6 Shapes an Immunosuppressive Microenvironment That Drives Melanomagenesis and Response To Checkpoint Blockade Therapy(Nature Portfolio, 2024) Wee, Yinshen; Wang, Junhua; Wilson, Emily C.; Rich, Coulson P.; Rogers, Aaron; Tong, Zongzhong; Grossmann, Allie H.Tumour-host immune interactions lead to complex changes in the tumour microenvironment (TME), impacting progression, metastasis and response to therapy. While it is clear that cancer cells can have the capacity to alter immune landscapes, our understanding of this process is incomplete. Herein we show that endocytic trafficking at the plasma membrane, mediated by the small GTPase ARF6, enables melanoma cells to impose an immunosuppressive TME that accelerates tumour development. This ARF6-dependent TME is vulnerable to immune checkpoint blockade therapy (ICB) but in murine melanoma, loss of Arf6 causes resistance to ICB. Likewise, downregulation of ARF6 in patient tumours correlates with inferior overall survival after ICB. Mechanistically, these phenotypes are at least partially explained by ARF6-dependent recycling, which controls plasma membrane density of the interferon-gamma receptor. Collectively, our findings reveal the importance of endomembrane trafficking in outfitting tumour cells with the ability to shape their immune microenvironment and respond to immunotherapy. The small GTPase ARF6 is known to regulate endocytosis and recycling of plasma membrane proteins. Here the authors show that tumourintrinsic ARF6 promotes an immunosuppressive microenvironment that accelerates melanoma progression but that is vulnerable to immune checkpoint blockade, mechanistically linked to ARF6-dependent recycling of interferon-gamma receptors in tumour cells.