WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
Permanent URI for this collectionhttps://hdl.handle.net/11147/7150
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Conference Object Citation - Scopus: 2Parkinson hastalığı sınıflandırmasına yönelik ivmeölçer tabanlı zamanlama analizi(IEEE, 2023) Karaçalı, Bilge; Onay, FatihParkinson's disease is a neurodegenerative disorder caused by dopamine deficiency in the basal ganglia, resulting in cognitive and motor impairments. In this study, accelerometer signals were used to estimate the delay time between the command to start pedaling and the actual movement onset in three groups: healthy individuals (n=13), Parkinson's disease patients (n=13), and patients with freezing of gait symptoms (n=13). Features were extracted from the delay time distributions for each participant and subjected to a triple classification. Linear support vector machine achieved a classification accuracy of 69.2% for all participants. Notably, the average time to start pedaling was found to be significantly different among the three groups, and accelerometer-based timing analysis could be used as a diagnostic tool to assist clinical tests.Book Part Citation - WoS: 299Citation - Scopus: 406Introduction To Machine Learning(Humana Press, 2014) Baştanlar, Yalın; Özuysal, MustafaThe machine learning field, which can be briefly defined as enabling computers make successful predictions using past experiences, has exhibited an impressive development recently with the help of the rapid increase in the storage capacity and processing power of computers. Together with many other disciplines, machine learning methods have been widely employed in bioinformatics. The difficulties and cost of biological analyses have led to the development of sophisticated machine learning approaches for this application area. In this chapter, we first review the fundamental concepts of machine learning such as feature assessment, unsupervised versus supervised learning and types of classification. Then, we point out the main issues of designing machine learning experiments and their performance evaluation. Finally, we introduce some supervised learning methods.Article Citation - WoS: 30Machine Learning Methods for Microrna Gene Prediction(Humana Press, 2014) Saçar, Müşerref Duygu; Allmer, JensMicroRNAs (miRNAs) are single-stranded, small, noncoding RNAs of about 22 nucleotides in length, which control gene expression at the posttranscriptional level through translational inhibition, degradation, adenylation, or destabilization of their target mRNAs. Although hundreds of miRNAs have been identified in various species, many more may still remain unknown. Therefore, discovery of new miRNA genes is an important step for understanding miRNA-mediated posttranscriptional regulation mechanisms. It seems that biological approaches to identify miRNA genes might be limited in their ability to detect rare miRNAs and are further limited to the tissues examined and the developmental stage of the organism under examination. These limitations have led to the development of sophisticated computational approaches attempting to identify possible miRNAs in silico. In this chapter, we discuss computational problems in miRNA prediction studies and review some of the many machine learning methods that have been tried to address the issues.