WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
Permanent URI for this collectionhttps://hdl.handle.net/11147/7150
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Article Vibration-Assisted Fluidization of Nanocellulose(Elsevier, 2026) Salimi, Sina; Hoorijani, Hamed; Zarghami, Reza; Sotudeh-Gharebagh, Rahmat; Van Geem, Kevin M.Nanocellulose, a renewable nanomaterial prized for its mechanical strength, biocompatibility, and tunable properties, faces challenges in gas-solid fluidization due to nanoparticle agglomeration, weak gas-solid interactions, and high elutriation caused by strong interparticle forces. This study uses pressure fluctuation analysis across frequency and time-frequency (wavelet transform) domains to investigate nanocellulose fluidization in a gas-solid bed. Mechanical vibration was introduced to optimize fluidization, with effects compared against nonvibrated conditions. Results show vibration significantly reduces agglomerate size and enhances bed expansion, improving fluidization efficiency. Notably, vibration lowers the minimum gas velocity requirement by approximately 4-fold. Pressure fluctuation analysis reveals that vibration amplifies low-frequency energy, fostering smaller bubbles and shifting energy contributions from large agglomerates to finer hydrodynamic structures. This shift correlates with intensified agglomerate interactions, leading to breakup and size reduction. Finally, the effect of introducing a powder additive to the nanocellulose bed on the hydrodynamics was examined, showing a moderate rise in macroscale energy at 1 % additive loading and a pronounced shift at 2 %, where macro structures accounted for nearly 45 % of the spectral energy. Overall, these findings underscore vibration-assisted fluidization as a promising method for scalable nanocellulose processing, offering actionable insights for advancing industrial applications.Article Citation - WoS: 31Citation - Scopus: 34Curcumin: Novel Treatment in Neonatal Hypoxic-Ischemic Brain Injury(Frontiers Media S.A., 2019) Rocha-Ferreira, Eridan; Sisa, Claudia; Bright, Sarah; Fautz, Tessa; Harris, Michael; Riquelme, Ingrid Contreras; Kurulday, Tuğçe; Hristova, MariyaHypoxic-ischemic encephalopathy (HIE) is a major cause of mortality and morbidity in neonates, with an estimated global incidence of 3/1,000 live births. HIE brain damage is associated with an inflammatory response and oxidative stress, resulting in the activation of cell death pathways. At present, therapeutic hypothermia is the only clinically approved treatment available for HIE. This approach, however, is only partially effective. Therefore, there is an unmet clinical need for the development of novel therapeutic interventions for the treatment of HIE. Curcumin is an antioxidant reactive oxygen species scavenger, with reported anti-tumor and anti-inflammatory activity. Curcumin has been shown to attenuate mitochondrial dysfunction, stabilize the cell membrane, stimulate proliferation, and reduce injury severity in adult models of spinal cord injury, cancer, and cardiovascular disease. The role of curcumin in neonatal HIE has not been widely studied due to its low bioavailability and limited aqueous solubility. The aim of this study was to investigate the effect of curcumin treatment in neonatal HIE, including time of administration and dose-dependent effects. Our results indicate that curcumin administration prior to HIE in neonatal mice elevated cell and tissue loss, as well as glial activation compared to HI alone. However, immediate post-treatment with curcumin was significantly neuroprotective, reducing grey and white matter tissue loss, TUNEL+ cell death, microglia activation, reactive astrogliosis, and iNOS oxidative stress when compared to vehicle-treated littermates. This effect was dose-dependent, with 200 mu g/g body weight as the optimal dose-regimen, and was maintained when curcumin treatment was delayed by 60 or 120 min post-HI. Cell proliferation measurements showed no changes between curcumin and HI alone, suggesting that the protective effects of curcumin on the neonatal brain following HI are most likely due to curcumin's anti-inflammatory and antioxidant properties, as seen in the reduced glial and iNOS activity. In conclusion, this study suggests curcumin as a potent neuroprotective agent with potential for the treatment of HIE. The delayed application of curcumin further increases its clinical relevance.