WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

Permanent URI for this collectionhttps://hdl.handle.net/11147/7150

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  • Article
    Citation - WoS: 6
    Citation - Scopus: 6
    A Comparative Study of Hplc and Uv Spectrophotometric Methods for Oseltamivir Quantification in Pharmaceutical Formulations
    (Akademiai Kiado, 2022) Güngör, Serdar; Aydın, Beyza Sultan; Aydın, Beyza Sultan; İlikçi Sağkan, Rahşan; 04.03. Department of Molecular Biology and Genetics; 04. Faculty of Science; 01. Izmir Institute of Technology
    Oseltamivir is an antiviral drug and is used in the treatment of all influenza viruses. It is the most effective antiviral option against all influenza viruses that can infect humans. UV and LC methods have been developed and validated according to ICH guidelines for various parameters like selectivity, linearity, accuracy, precision, LOD and LOQ, robustness for the quantitative determination of oseltamivir in pharmaceutical formulations. LC method has been performed using reverse phase technique on a C-18 column with a mobile phase consisting of 20 mM potassium dihydrogen phosphate solution and acetonitrile (60:40, v/v) at 25 8C. The mobile phase flow rate was 1.2 mL min-1. For the determination of oseltamivir, UV spectrum has been recorded between 200 and 800 nm using methanol as solvent and the wavelength of 215 nm has been selected. Both methods have demonstrated good linearity, precision and recovery. No spectral and chromatographic interferences from the capsule excipients were found in UV and LC methods. In both methods, correlation coefficients were greater than 0.999 within a concentration range of 10???60 mg mL-1 using UV and LC. Intra-day and inter-day precision with low relative standard deviation values were observed. The accuracy of these methods was within the range 99.85???100.17% for LC and from 99.26 to 100.70% for UV. Therefore UV and LC methods gave the most reliable outcomes for the determination of oseltamivir in pharmaceutical formulation.
  • Article
    Citation - WoS: 23
    Citation - Scopus: 26
    Curvature-Restored Gauge Invariance and Ultraviolet Naturalness
    (Hindawi Publishing Corporation, 2016) Demir, Durmuş Ali; Demir, Durmuş Ali; 04.05. Department of Pyhsics; 04. Faculty of Science; 01. Izmir Institute of Technology
    It is shown that (aΛ2+b|H|2)R in a spacetime of curvature R is a natural ultraviolet (UV) completion of (aΛ4+bΛ2|H|2) in the flat-spacetime Standard Model (SM) with Higgs field H, UV scale Λ, and loop factors a and b. This curvature completion rests on the fact that Λ-mass gauge theory in flat spacetime turns, on the cut view R=4Λ2, into a massless gauge theory in curved spacetime. It provides a symmetry reason for curved spacetime, wherein gravity and matter are both low-energy effective phenomena. Gravity arises correctly if new physics exists with at least 63 more bosons than fermions, with no need to interact with the SM and with dark matter as a natural harbinger. It can source various cosmological, astrophysical, and collider phenomena depending on its spectrum and couplings to the SM.