WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

Permanent URI for this collectionhttps://hdl.handle.net/11147/7150

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  • Article
    Design Strategies to Optimize Polymeric Vectors for mRNA Delivery
    (Taylor and Francis Ltd., 2025) Turhan, Z.Y.; Savaş, M.; Alakbarov, A.; Bulmus, V.
    mRNA holds great promise for preventing and treating a variety of diseases, from infectious diseases to diverse cancers, owing to its transient expression, lack of genomic integration, and scalable production. Among non-viral vectors, polymeric carriers are attractive due to their synthetic versatility and stability, which allow for precise tuning for efficient mRNA delivery. Their scalability further supports the applicability of polymeric vectors. Studies have addressed the room for improvement in polymeric systems for mRNA delivery and have adapted varying approaches depending on the type of polymeric structure, including but not limited to PEGylation, hydrophobic modification, and incorporation of responsive or targeting moieties. This review summarizes advances in polymeric vectors for mRNA delivery and highlights how distinct structural modifications influence toxicity, mRNA transfection efficiency, biodistribution, intracellular trafficking and immune activation, providing a framework for the rational design of next-generation polymeric vectors that can fully realize the clinical potential of mRNA therapeutics. © 2025 Taylor & Francis Group, LLC.
  • Article
    Industrial History and Heritage of the Karaburun Mercury Mining District, Türkiye
    (Taylor and Francis Ltd., 2025) Yılmazer, Aslıhan; Gönülal, Yasemin Özcan; Yüceer, Hülya
    Mining metallic resources has been important to technological advancement since prehistoric times and has contributed to the progress of civilisation. Mining heritage includes sites and structures related to mining that reveal historical and cultural insights. The remains of structures in the mercury mining district on the Karaburun peninsula of Izmir in Türkiye, which includes the Kalecik, Karareis and Dikencik mines, is one such site. Despite its abandonment and subsequent damage, research has highlighted the importance of the district during the late Ottoman empire and the early years of the Republic as a source of cinnabar, the most common source ore for refining elementary mercury. Comparable mines elsewhere have been transformed into heritage sites and tourist attractions, such as at Monte Amiata in Italy and Idrija in Slovenia. In view of the potential, this study aimed to establish the historical and industrial significance of the Karaburun mercury mining district through detailed research and site survey to form a robust base for a holistic conservation approach. © 2025 Elsevier B.V., All rights reserved.
  • Article
    Citation - WoS: 1
    Citation - Scopus: 1
    Optimized Lithium(I) Recovery From Geothermal Brine of Germencik, Türkiye, Utilizing an Aminomethyl Phosphonic Acid Chelating Resin
    (Taylor and Francis Ltd., 2025) Recepoğlu, Y.K.
    This study investigates the performance of Lewatit TP 260 ion exchange resin for the efficient recovery of lithium (Li(I)) from geothermal water sourced from the Germencik Geothermal Power Plant in Türkiye. A series of batch sorption experiments were performed to evaluate the influence of key parameters, including resin dosage, solution pH, temperature, initial Li(I) concentration, and contact time, on the Li(I) recovery process. The optimal conditions were determined to be a resin dose of 0.5 g per 25 mL of geothermal water, pH in the range of 6–8, and a temperature of 25°C. Under these conditions, the resin achieved a maximum Li(I) recovery rate of 71% from the geothermal water. Sorption isotherms were further analyzed using the Langmuir, Freundlich, and Dubinin-Radushkevich (D-R) models. Among these, the Langmuir model provided the best fit (R² = 0.9841), suggesting a maximum sorption capacity (qm) of 4.31 mg/g. Continuous recovery experiments conducted in column mode confirmed the practical applicability of Lewatit TP 260, achieving a total sorption capacity of 0.41 mg Li(I)/mL resin. The findings exhibit the potential of this resin as a viable sorbent for sustainable Li(I) extraction from geothermal brines, supporting the development of green energy technologies and contributing to the circular economy. © 2024 Taylor & Francis Group, LLC.
  • Article
    Effects of Span 60 Template and Freeze Drying on Zinc Borate Produced From Zinc Nitrate Hexahydrate and Borax Decahydrate
    (Taylor and Francis Ltd., 2022) Alp, Burcu; Gönen, Mehmet; Atakul Savrık, Sevdiye; Balköse, Devrim
    Zinc borate is an important additive to polymers and lubricants. The process variables such as reactant concentration, presence of template in precipitating medium and drying method determine the composition and particle size of zinc borates. In the present study, zinc borate precipitate obtained by mixing aqueous zinc nitrate and borax decahydrate solutions was dried either by conventional method or by freeze drying. The products were well characterized by advanced methods. Zinc borate from 1 mol dm(-3) reactants had (2.1 +/- 0.5)x(2.5 +/- 0.5)x(1.3 +/- 0.2) mu m and (0.5 +/- 0.1)x(1.3 +/- 0.1)x(0.028 +/- 0.01) mu m dimensions by conventional and freeze drying respectively. Individual particles smaller in size is obtained since the particles are not agglomerated due to absence of surface tension of liquid water for case of freeze drying. Planar particles agglomerated into 20 to 60 mu m crystals in the presence of template Span 60 in 1 mol dm(-3) reactants for conventional drying. Nano zinc borate particles with primary particle size of (46 +/- 9) nm were obtained by decreasing the reactant concentration to 0.1 mol dm(-3). The primary particle size was decreased to (40 +/- 3) nm by addition of Span 60 to dilute solutions. However zinc borate nanoparticles obtained from dilute solutions adhered to each other forming agglomerates during conventional drying. Their freeze drying would allow formation of a freely flowing nano powder.
  • Article
    Citation - WoS: 2
    Citation - Scopus: 2
    A New Fluorescent 'turn On' Probe for Rapid Detection of Biothiols
    (Taylor and Francis Ltd., 2020) Üçüncü, Muhammed; Zeybek, Hüseyin; Karakuş, Erman; Üçüncü, Canan; Emrullahoğlu, Mustafa
    We designed and synthesised a novel molecular probe exhibiting high selectivity and sensitivity towards reactive sulphur species (RSS) over other amino acids and biologically relevant species, as well as scrutinised its spectroscopic behaviours under physiological conditions and in living milieu. We used an electrophilic cyanate group as a masking agent to block the excited state intramolecular proton transfer process of 2-(2-cyanato-3-methoxyphenyl)benzo[d]thiazole (HMBT-OCN), which readily hydrolyses to the highly fluorescent structure, 2-(2'-Hydroxy-3'-methoxyphenyl) benzothiazole (HMBT-OH), in the presence of reactive sulphur species. [GRAPHICS] .
  • Article
    Citation - WoS: 7
    Citation - Scopus: 11
    Chemical Composition and Biological Activities of Cypriot Propolis
    (Taylor and Francis Ltd., 2021) Nalbantsoy, Ayşe; Sarıkahya, Nazlı Böke; Özverel, Cenk Serhan; Barlas, Ayşe Berçin; Kırcı, Damla; Akgün, İsmail Hakkı; Yalçın, Tansel; Güven, Gamze; Kışla, Duygu; Demirci, Betül; Topçu, Gülaçtı; Gören, Ahmet Ceyhan
    Propolis compositions are highly variable, depending on the geographic region and the season of collection. In this study, propolis samples from seven different regions of Cyprus were studied for the first time by means of chemical content and biological activities. Secondary metabolite composition was determined by LC-HRMS. While the major flavonoids found were isosakuranetin, naringenin, rhamnocitrin, diosmetin, chrysin and acacetin, interestingly verbascoside, a phenylethanoid glycoside, and chlorogenic acid were identified as the major compounds in the ethanol-water extracts. alpha-Pinene was detected as the major compound of propolis extracts according to the volatile compositions via GC-MS. Karaoglanoglu and Tirmen extracts, presenting different chemical profiles, exerted enormous cytotoxic activity by MTT assay (IC50: 2.36-11.56 mu g/mL; 1.44-9.33 mu g/mL, respectively). The highest iNOS inhibition potential was detected in the Karpaz extract (IC50:2.6 mu g/mL) in LPS induced RAW 264.7 cells whereas the Guzelyurt sample demonstrated remarkable antioxidant (88.82 +/- 0.10%) and antimicrobial activities (with a MIC value of 31.2 mu g/mL against S. aureus, S. epidermidis, E. faecium, and E. faecalis).
  • Article
    Citation - WoS: 37
    Mechanisms of Cellular Resistance To Imatinib in Human Chronic Myeloid Leukemia Cells
    (Taylor and Francis Ltd., 2007) Baran, Yusuf; Ural, Ali Uğur; Gündüz, Ufuk
    A major advancement in the treatment of chronic myeloid leukemia (CML) has been the development of imatinib, which has shown striking activity in the chronic phase and the accelerated phase, but less so in the blast phase of the disease. Despite high rates of hematologic and cytogenetic responses to therapy, the emergence of resistance to imatinib has been recognized as a major problem in the treatment of patients with CML. Various cellular mechanisms may be involved in the nature of cellular resistance. Increased amount of target, alteration in structure of target proteins, decreased drug uptake and increased detoxification are well-known mechanisms of resistance. On the other hand, in some cases, even if anticancer drugs reach their sites of action, bypassing drug efflux system of the cells, some cells still may survive via the dysregulation of apoptotic signalling. In this study, mechanisms of resistance to imatinib-induced apoptosis in human Meg-01 CML cells were examined. Continuous exposure of cells to step-wise increasing concentrations of imatinib resulted in the selection of 200- and 1000 nM imatinib-resistant sub-lines referred to as Meg-01/IMA-0,2 and Meg-01/1MA-1, respectively. MTT cell proliferation, cell cycle analyses and trypan blue dye exclusion analyses showed that Meg-0l/IMA-1 cells were resistant to imatinib-induced apoptosis as compared to parental sensitive cells. There was an increased expression of BCR/ABL, Bcl-2 and an increase in mitochondrial membrane potential (MMP) detected in resistant cells comparing to parental sensitive cells. There was no mutation detected in imatinib binding site of ABL kinase region. Various diverse mechanisms have been reported for their involvement in the multidrug resistance. In this study, it has been shown that the degree of BCR/ABL expression appears to be directly proportional to the levels of imatinib resistance. In addition, there have been BCR/ABL-independent mechanisms reported for deriving resistance against imatinib. Our results revealed that besides BCR/ABL overexpression, imatinib resistance also depends on the inhibition of apoptosis as a result of up-regulation of anti-apoptotic stimuli and down-regulation of pro-apoptotic stimuli through MMP but does not depend on any mutation on imatinib binding site of ABL kinase.
  • Article
    Citation - WoS: 1
    Princesses Versus Maids: Domesticating Electricity in the Early Republican Period in Turkey
    (Taylor and Francis Ltd., 2019) Emgin, Bahar
    This article is concerned with the question of how electricity was introduced into the home in Turkey during a period when electrification of the country ran in parallel with the establishment of the new republic. Republican discourses of modernization and progress attributed electricity a symbolic transformative power. Yet, the robust power of electricity had to be domesticated before it was introduced into the homes to comply with the ideal of modern home. Visual representations of electricity constituted a crucial step in this process of domestication. To figure out the visual strategies of domestication the study focuses on the representations of electricity produced by prominent mediators of domestic electricity during the period. These include the bi-monthly publication of Istanbul's electric providerSociete Anonyme d'Installations Electriques(SATIE) namedAmeli Elektrikand prominent women's and family magazines of the period, which areYedigunandEv-Is. Dwelling on advertisement images, cover illustrations and promotional pieces, this article identifies two main visual strategies of domestication, namely mythification and anthropomorphization. Throughout the text it is argued that visual representations of electricity for residential users undermined the quasi-neutral definition of electricity as a modern power and rather worked to frame electricity as a means of distinction and pictured a pretentious modernity.
  • Article
    Citation - WoS: 1
    Citation - Scopus: 2
    Consolidation of a Bath Ruin in an Archaeological Site
    (Taylor and Francis Ltd., 2022) Durmuşlar, Feyza; Turan, Mine; Yücetürk, Kutay; Aktaş, Engin
    The study has focused on consolidation of a historical bath ruin in an archaeological site. Cevher Pasa Bath, which is located in Tabae archaeological site in Denizli, Turkey and dated to the 15th century, presents structural problems. The aim of the study is to propose a framework for planning consolidation of the ruins of Cevher Pasa Bath so that conservation work regarding similar masonry ruins in archaeological sites can be guided. Thus, methods of architectural restoration and civil engineering are combined in an interdisciplinary scope. Provision of temporary shoring as an emergency intervention, consolidation and presentation of the ruin within the scope of an interdisciplinary restoration project, and monitoring of the asset within the frame of a monument management plan are suggested, respectively. Structural analysis considering stress and overturning moment checks are performed. Consolidation work includes only supporting of arch remains. Some walls of the ruin are weaker than other parts. These parts need further detailed analysis, and if necessary, further consolidation and strengthening are to be carried out. The monument management plan points out the necessity of collaboration of local and central administrations, and also non-governmental organisations.
  • Conference Object
    Detection of Urban Change Using Remote Sensing and Gis: Izmir Case
    (Taylor and Francis Ltd., 2008) Tarhan, Çiğdem; Arkon, Cemal; Çelik, M.; Gümüştekin, Şevket; Tecim, V.
    This study is an example of how land use changes could be detected via high resolution remotely sensed data. In order to perform "change detection" IKONOS satellite images, belonging to 2001 and 2004, have been used. An automated Graphical User Interface (GUI) has been created for detection of environment. Different image enhancement techniques and a fuzzy inference system have been combined in the GUI. The detection results are classified according to some basic levels such as 20-50% and 70%. Additionally, four different change detection algorithms have been applied which are pixel-based, object based, feature based. These algorithms have been examined according to change detection levels with different image enhancement techniques. At the end of the study, the results have been compared.