WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

Permanent URI for this collectionhttps://hdl.handle.net/11147/7150

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  • Article
    Citation - WoS: 4
    Citation - Scopus: 3
    Exploration of Electrostatics Effect on Dispersion and Coating Mechanisms in Dry Powder Inhalers by Discrete Element Method
    (Elsevier, 2025) Saeid, Pooya; Kazemi, Saman; Zarghami, Reza; Sotudeh-Gharebagh, Rahmat; Mostoufi, Navid
    Improving drug delivery in the respiratory system relies on the effective coating and dispersion of active pharmaceutical ingredients (APIs) in dry powder inhalers (DPIs) and the respiratory system's airways. This study aims to explore the impact of different factors on coating APIs on carrier particles, considering electrostatic and van der Waals forces using the discrete element method (DEM). This study focuses on the critical elements of API dispersion, specifically collisions between API-coated carrier particles with each other and DPI walls. The factors influencing the dispersion ratio in these collisions, such as impact velocity, contact angle, and particle charge, are examined. Additionally, a reduced-scale shaking DPI with three frequencies is used to investigate the API coating mechanism on carriers, which was not explored in previous studies. The difference in work function between carrier particles and APIs generates charge in the shaking DPI due to collisions. This causes electrostatic force to dominate over van der Waals force, breaking agglomerates and attaching APIs to carrier particles. This study shows that the amount of generated charge increases with particle collisions and that charge distribution becomes more balanced over time through charge exchange between particles. By elucidating the relationships among impact velocity, dispersion ratio, shaking frequency, and contact angles, this study paves the way for future research on more efficient DPI designs.
  • Article
    Citation - WoS: 4
    Citation - Scopus: 4
    Optimizing the Dispersion of Calcium Phosphate Nanoparticles for Cellular Studies Using Statistical Design of Experiments
    (Elsevier, 2023) Önder, Anıl Can; Tomak, Aysel; Öksel Karakuş, Ceyda
    The in vitro experimentation of ceramic nanoparticles often requires their dispersion in liquid media without causing particle clumps or deteriorating sample integrity. However, the dispersion of nanoparticles using the available protocols rarely leads to stable and uniform dispersions which, in turn, raises concerns about the validity, repeatability and comparability of the findings observed in vitro. Moreover, the ability to control the final dispersion quality of ceramic nanoparticles is an essential step to obtaining optimized nanoceramic materials with desired functionality and to enhancing their performance in subsequent applications. While the need to have a comprehensive guideline for the dispersion of nanoparticles has led to several published documents and protocols, the dispersion methodology of ceramic nanoparticles and the relative contribution of the experimental parameters to the quality of resulting dispersion are still not clear. Here, we employed the statistical design of experiment (DoE) approach to systematically assess the magnitude and source of variation in dispersion quality of two different ceramic nanoparticles, hydroxyapatite and tricalcium phosphate. Using the first-order Plackett-Burman Design (PBD), nanoparticle concentration, pH and the presence of an additive were identified as the most critical factors influencing the resulting hydrodynamic size and zeta potential of the ceramic nanoparticles. Optimization using a second-order Central Composite Design (CCD) yielded a set of quadratic regression equations that were used to predict the hydrodynamic size or zeta potential of ceramic nanoparticles with high accuracy (R2, 0.88–0.92). The results of PBD screening and CCD optimization experiments were employed to prepare nanoparticle dispersions of different quality, which were then used to compare the effect of aggregation on the viability of human osteosarcoma (SaOS-2) cells. Overall, the results of this study provided insight into the role that various experimental parameters play in the colloidal stability and dispersion of ceramic nanoparticles. © 2023