WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
Permanent URI for this collectionhttps://hdl.handle.net/11147/7150
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Article Citation - WoS: 1Citation - Scopus: 1Peptide-Functionalized Hydrocolloid Bioink for 3D Bioprinting in Dental Tissue Engineering(Elsevier, 2025) Guner, Elif; Yildirim-Semerci, Ozum; Altan, Zeynep; Arslan-Yildiz, AhuDeveloping biomimetic peptide-based biomaterials has utmost importance to enhance mineralization offering an innovative approach for dental tissue regeneration. This study comprises development and characterization of a novel peptide-based hybrid bioink for dental tissue engineering applications by integrating P11-4 peptide and Gelatin (Gel) into glucuronoxylan-based quince seed hydrocolloid (QSH). Combining polysaccharide and peptide-based hydrogels enhanced cell adhesion and mineralization. Morphological analysis showed that P11-4 increased porosity, while rheological tests confirmed that QSH/Gel/P11-4 bioink has tunable viscosity, which is suitable for 3D bioprinting. Optimized bioprinting parameters were determined to be 25G nozzle diameter, 10 mm/s speed of movement, 0.1 mm layer height, and pressure values of 9.0 and 7.0 psi for QSH/Gel and QSH/ Gel/P11-4, respectively. Moreover, the addition of P11-4 significantly increased protein adsorption without affecting swelling capacity. 3D cell culture studies were conducted using SaOS-2 (human osteosarcoma) cells, then biocompatibility, high cell viability, favored adhesion, and proliferation were confirmed by Live/Dead and MTT assays. Alizarin Red Staining (ARS) and EDX analysis verified that P11-4 promoted mineral deposition by increasing Calcium (Ca2+) accumulation in QSH/Gel/P11-4 scaffolds, suggesting that developed bioink can mimic native ECM microenvironment for dental tissue. Overall, the developed hybrid bioink shows superior printability and bioactivity, which makes it a promising material for 3D bioprinting applications in dental tissue engineering.Article Citation - WoS: 1Citation - Scopus: 1Mineralization of Olive Mill Wastewater Under Hydrothermal Conditions(Desalination Publications, 2019) Ersanlı, Çağlar; Yüksel Özşen, AslıOlive mill wastewater (OMW) is highly dangerous for land and aquatic environments because of its high phenolic content, acidity, and salinity. Hence, hydrothermal degradation of OMW in subcritical water medium with and without using external oxidizer (H2O2) was studied to decrease its total organic carbon (TOC), total phenolic content (TPC), and color. Effects of reaction temperature (150 degrees C-250 degrees C), reaction time (30-120 min), and H2O2 content (0-100 mM) on TOC and TPC of OMW were investigated. Box-Behnken-type experimental design and statistical analysis (analysis of variance) were practiced by Design Expert 11. According to statistical analysis, effect of reaction temperature significantly affected TOC removal efficiency. The best TOC reduction (31.65%) was achieved without using H2O2 at 250 degrees C for 120 min.