WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

Permanent URI for this collectionhttps://hdl.handle.net/11147/7150

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Now showing 1 - 10 of 208
  • Article
    Encapsulation of IR783 in UiO-66 MOFs for Improved Photodynamic Efficacy Against Breast Cancer Cells
    (OICC Press, 2025) Sahinoglu, Sinem; Sanli-Mohamed, Gulsah
    Breast cancer remains the most prevalent malignancy among women worldwide, underscoring the need for innovative therapeutic strategies beyond conventional modalities. Photodynamic therapy (PDT) offers a non-invasive approach that leverages light-activated photosensitizers to induce reactive oxygen species (ROS)-mediated tumor cell death. IR783, a near-infrared fluorescent (NIRF) heptamethine cyanine dye, has shown promise as a theranostic agent in cancer therapy due to its tumor-selective uptake and pro-apoptotic effects. However, its clinical potential is hindered by poor stability, rapid dissociation in polar environments, low quantum yield, and suboptimal tumor accumulation. In this study, we developed a multifunctional nanoplatform by encapsulating IR783 into UiO-66, a zirconium-based metal-organic framework (MOF), to enhance the delivery and photodynamic performance of the dye (IR783@UiO-66). The system was structurally characterized, and its biocompatibility and drug release profiles were evaluated. In vitro experiments were conducted to assess the cytotoxic and phototoxic effects of IR783, UiO-66, and IR783@UiO-66 on breast cancer cell lines (MCF-7, MDA-MB-231) and normal breast epithelial cells (MCF-10A), under LED irradiation at varying light intensities (18-144 J/cm2) and exposure durations (7.5-60 min). The results demonstrated that IR783@UiO-66 significantly reduced cancer cell viability in a dose-and light-dependent manner while sparing normal cells. Free IR783 showed slightly higher phototoxicity, attributed to differences in release kinetics and loading efficiency. UiO-66 alone exhibited negligible cytotoxicity under irradiation, confirming its safety profile. This study highlights the potential of UiO-66 as a promising nanocarrier for enhancing IR783-mediated PDT, offering a synergistic strategy for targeted and efficient breast cancer therapy.
  • Conference Object
    Speckle Intensity Correlation Distribution Analysis Based on Coincidence Detection for Scattering Medium Characterization
    (IEEE, 2025) Yoldas, Cansu; Kisa, Alperen; Atac, Enes; Karatay, Anil; Dinleyici, Mehmet Salih
    Characterizing a scattering medium is essential for understanding and controlling light propagation, enabling accurate imaging, correlation analysis, and material diagnostics in scientific applications. In this study, the scattering medium has been characterized by examining the spatial distribution of the second-order temporal correlation function of varying speckle patterns obtained under faint-light conditions using a charge-coupled device (CCD) camera. In the proposed method, the exposure time has been utilized as a self-coincidence circuit of the CCD. The spatial statistics of second-order temporal autocorrelation values have been analyzed through power spectral density and radial spatial autocorrelation function. The scattering degree of the medium has been determined using our proposed autocorrelation-based metric. The results from three different media have shown that the method is effective and holds potential for applications such as characterization through speckle imaging.
  • Conference Object
    Citation - WoS: 10
    A Turkish Dataset for Gender Identification of Twitter Users
    (Assoc Computational Linguistics-ACL, 2019) Sezerer, Erhan; Polatbilek, Ozan; Tekir, Selma
    Author profiling is the identification of an author's gender, age, and language from his/her texts. With the increasing trend of using Twitter as a means to express thought, profiling the gender of an author from his/her tweets has become a challenge. Although several datasets in different languages have been released on this problem, there is still a need for multilingualism. In this work, we propose a dataset of tweets of Turkish Twitter users which are labeled with their gender information. The dataset has 3368 users in the training set and 1924 users in the test set where each user has 100 tweets. The dataset is publicly available(1).
  • Conference Object
    Citation - WoS: 13
    Automatic HTML Code Generation from Mock-Up Images Using Machine Learning Techniques
    (IEEE, 2019) Asiroglu, Batuhan; Mate, Busra Rumeysa; Yildiz, Eyyup; Nalcakan, Yagiz; Sezen, Alper; Dagtekin, Mustafa; Ensari, Tolga
    The design cycle for a web site starts with creating mock-ups for individual web pages either by hand or using graphic design and specialized mock-up creation tools. The mock-up is then converted into structured HTML or similar markup code by software engineers. This process is usually repeated many more times until the desired template is created. In this study, our aim is to automate the code generation process from hand-drawn mock-ups. Hand drawn mock-ups are processed using computer vision techniques and subsequently some deep learning methods are used to implement the proposed system. Our system achieves 96% method accuracy and 73% validation accuracy.
  • Article
    The Building That Was a Timepiece: Translating The Time Regulation Institute to Architecture
    (Intellect Ltd, 2025) Kilinc, Kivanc; Anouti, Ghida; Kassar, Hadi; Karam, Ralph
    How could one forge a creative dialogue between texts and the physical spaces that they document, imagine or reinvent? This article explores the idea of intersemiotic translation from a work of literature to architecture through a selection of student works produced in an undergraduate elective (Building Texts) offered online 2020 in the Department of Architecture and Design at the American University Beirut (AUB). In the course, students were given the task of 'building' the Turkish novelist Ahmet Hamdi Tanp & imath;nar's internationally acclaimed novel, The Time Regulation Institute (1961) in the form of visual representation. The purpose was not to illustrate the content but trigger an intermedial exchange: Tanp & imath;nar's novel gives a detailed account a fictional modern institute, which serves no purpose other than synchronizing every clock in the country and fine those whose watches are running slow. But the complexity and eclectic character of the architecture, as well as the absurdity of its supposed function, compelled students to go beyond straightforward solutions and minimized the likelihood of 'translating' the content into familiar shapes and forms. By introducing one final project in more detail that explores translation as a central theme, the article discusses how such interactions between architecture and literature could be mobilized as an imaginative pedagogical tool. As the project illustrates, students have not only connected textual spaces to the 'actual spaces' informing the novel's narrative structure but also critically resituated these spatial discourses within the mutually dependent social, political and cultural contexts in which they were imagined.
  • Article
    Rhythmanalysis of Istanbul Ayasofya's (re)mosquification During the COVID-19 Pandemic: A Diachronic Overview
    (Routledge Journals, Taylor & Francis Ltd, 2025) Akture, Zeynep; Kazanasmaz, Zehra Tugce
    Inauguration of the Grand Mosque of Ayasofya, Istanbul, in 2020 was among the cultural heritage-related magnet events of the COVID-19 pandemic period. This essay focuses on the impacts of function change on the monument's spatial experience, by tracing a continuity of change in its everyday life and use in a continuously changing urban context, through comparatively minor physical interventions starting with the 'necessary minimum' to its 'acupuncture points', as was done during its earlier mosquification and museumification, both of which (were) initiated (by) structural transformations in the longue dur & eacute;e. Following Henri Lefebvre's argument on spatiality of politics and history, and adopting his rhythmanalysis tool, significance of the recent function change is argued to reside in the resulting spatial experience that is characterised by spatiotemporally alternating and/or overlapping political, religious, and tourist 'rituals' that are conditioned by and conditioning longer-term structural changes. Concluding observations target future research along the proposed trajectory.
  • Conference Object
    Avoidance of Feature Configuration Faults in Software Product Lines
    (IEEE Computer Soc, 2025) Ergun, Burcu; Tuglular, Tugkan; Belli, Fevzi
    This paper presents a validation approach to feature selection in software product lines (SPL). SPLs consist of similar products tailored to different needs, while SPLs sharing a common platform where feature configurations define product families. Validating feature configurations is critical to avoid defective shipments, recalls, and disposal. Exhaustive, pairwise, and combinatorial testing, among others, aim at ensuring configuration correctness. This paper introduces a novel method for improving feature selection and validation in SPLs by minimizing redundancy while ensuring configurations align with customer needs. The method emphasizes uncovering the differences in feature structures through "complex" and "simple" models, which helps identify and helps identify and tolerate potential errors arising from incorrect feature configurations. This ensures broader coverage while effectively managing dependencies. A case study using the Access Point (AP) SPL model, which is a networking device designed to enhance the strength of an existing wireless signal and expand its coverage area. The AP can enable or disable specific features on AP SPL depending on the characteristics of the third-party gateway with which it is integrated. AP SPL model with 66 features lead to 266 configurations, generated by Exhaustive Testing. Pairwise testing achieves 87% coverage with 132 test cases, while combinatorial testing reaches 94% with 45,760 cases. Our method ensures 100% feature coverage with just 3 test configurations. Thus, the approach introduced in this paper enhances product quality while reducing costs by avoiding redundant tests, making the approaches valuable for large-scale SPLs.
  • Conference Object
    Citation - Scopus: 1
    Binet–Fibonacci Calculus and N = 2 Supersymmetric Golden Quantum Oscillator
    (Springer International Publishing AG, 2025) Pashaev, Oktay K.
    The Binet-Fibonacci calculus, as phi phi'-two base quantum calculus, relates Fibonacci derivative with Binet formula of Fibonacci number operator, acting in Fock space of quantum states. It provides a tool to study the Golden oscillator with energy spectrum in form of Fibonacci numbers. Here we generalize this model to supersymmetric number operator and corresponding Binet formula for supersymmetric Fibonacci operator F-N. It determines the Hamiltonian of supersymmetric Golden oscillator, acting in. H-f circle times H-b-fermion-boson Hilbert space and belonging to N = 2 supersymmetric algebra. Trace on fermions of this model reduces the Hamiltonian to the Golden oscillator. The eigenstates of the super Fibonacci number operator are double degenerate and can be characterized by a point of the super-Bloch sphere. By the supersymmetric Fibonacci annihilation operator, we construct the coherent states as eigenstates of this operator. Entanglement of fermions with bosons in these states is calculated by the concurrence, represented by the Gram determinant and Fibonacci exponential functions. These functions have been appeared as descriptive for inner product of the Golden coherent states in Fock-Bargmann representation. The reference state, coming from the limit alpha -> 0 and corresponding von Neumann entropy, measuring fermion-boson entanglement, are characterized by the Golden ratio.
  • Conference Object
    Geometry and Entanglement of Super-Qubit Quantum States
    (Springer International Publishing AG, 2025) Pashaev, Oktay K.; Kocak, Aygul
    We introduce the super-qubit quantum state, determined by superposition of the zero and the one super-particle states, which can be represented by points on the super-Bloch sphere. In contrast to the one qubit case, the one super-particle state is characterized by points in extended complex plane, equivalent to another super-Bloch sphere. Then, geometrically, the super-qubit quantum state is represented by two unit spheres, or the direct product of two Bloch spheres. By using the displacement operator, acting on the super-qubit state as the reference state, we construct the super-coherent states, becoming eigenstates of the super-annihilation operator, and characterized by three complex numbers. The states are fermion-boson entangled, and the concurrence of states is the product of two concurrences, corresponding to two Bloch spheres. We show geometrical meaning of concurrence as distance from point-state on the sphere to vertical axes. Then, probabilities of collapse to the north pole state and to the south pole state are equal to half-distances from vertical coordinate of the state to corresponding points at the poles. For complimentary fermion number operator, we get the flipped super-qubit state and corresponding super-coherent state, as eigenstate of transposed super-annihilation operator. The infinite set of Fibonacci oscillating circles in complex plane, describing quantum states with uncertainty relations as the ratio of two Fibonacci numbers, and in the limit at infinity becoming the Golden Ration uncertainty, is derived.
  • Conference Object
    Velocity-Level Kinematics of a Continuously Variable Transmission System for Phri
    (Springer International Publishing AG, 2025) Mobedi, Emir; Dede, Mehmet Ismet Can
    New generation robots pave the way for physical human-robot interaction (pHRI) through improvements in control and design techniques. While the former is achieved with the help of a number of sensory information, variable stiffness actuators (VSA) are exploited for the design of these robots to achieve inherent compliance. Recently, continuously variable transmission-based VSA has been developed to be used for pHRI, specifically for haptics. The fundamental characteristic of this new CVT mechanism is that it regulates output position and torque independently via the sphere transmission element. In this study, velocity-level kinematics of this new CVT system is carried out to demonstrate its step-less speed variation feature. Moreover, simulations are conducted in ADAMS and Solidworks software packages at 8 transmission points selected unequally. Results show that the average value of overall ADAMS and Solidworks errors computed with respect to the computed velocity are reported as 1.09%, and 0.53%, respectively.