WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
Permanent URI for this collectionhttps://hdl.handle.net/11147/7150
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Article Citation - WoS: 2Citation - Scopus: 1Çelik Fiber Katkısının Farklı Boyuna Donatı Oranına Sahip Betonarme Döşemelerin Zımbalama Davranışı Üzerinde Etkileri(2019) Saatci, Selcuk; Yasayanlar, Suleyman; Yasayanlar, Yonca; Batarlar, BaturaySunulan çalışmada her iki yönde birbirine dik 0,004 (D1 serisi) ve 0,002 (D2 serisi) oranında boyuna donatıiçeren 2150x2150x150 mm boyutlarında iki grup betonarme döşeme, hacimce %0, %0,5, %1 ve %1,5oranında çelik fiber katkısı içeren beton karışımlarıyla dökülmüştür. Üretilen toplam sekiz döşeme ortanoktalarından statik yük altında test edilmişlerdir. Çelik fiber katkısı olmayan numunelerde yüksek boyunadonatı oranına sahip döşeme boyuna donatısında akma gerçekleşmeden gevrek bir şekilde zımbalamagöçmesi oluşurken düşük boyuna donatı oranına sahip döşeme zımbalama gerçekleşmeden önce çok dahasünek bir davranış göstermiştir. Çelik fiber katkısı her iki boyuna donatı oranında da iki kata varan oranlardazımbalama dayanımı artışlarına sebep olmuştur. Ancak D1 serisi döşemelerde çelik fiber katkısı maksimumyer değiştirmeleri önemli ölçüde arttırırken D2 serisinde maksimum yer değiştirmelerde önemli bir farkoluşmamış, bu döşemelerin yer değiştirmesi boyuna donatının akması tarafından kontrol edilmiştir. Çelikfiber katkısı oranının arttırılması D1 serisi döşemelerde dayanımın ve maksimum yer değiştirmelerinartmasına sebep olurken, D2 serisi döşemelerde %1'in üstü çelik fiber katkı oranları davranışta önemli birfark oluşturmamıştır. Yapılan deneyler Kritik Kesme Çatlağı Teorisi kullanılarak analitik olarakmodellenmiş ve bu tip modelleme ile ilgili bazı iyileştirmeler önerilmiştir.Article A Capsular Polysaccharide from a Healthy Human Microbiota Member Activates a Lag-3-NK Cell Axis to Restrain Colon Cancer and Augment Immunotherapy(Cell Press, 2025) Weis, Allison M.; Tang, William W.; Stephen-Victor, Emmanuel; Bell, Rickesha; Brown, D. Garrett; Round, June L.Colorectal cancer (CRC) is increasing globally, making identification of preventative measures necessary. Transplantation of the microbiota from CRC and non-CRC patients into mice demonstrates that non-diseased individuals possess organisms that reduce tumor formation and highlights Bacteriodes uniformis as protective. B. uniformis is reduced in humans with CRC, and proactive treatment with B. uniformis slows tumor growth in mice. Natural killer (NK) cells, but not T cells, are required for B. uniformis-mediated protection. CRC is recalcitrant to immunotherapies; however, addition of B. uniformis restores response to alpha-CTLA-4 treatment in an NK cell-dependent manner. We report that high Lag-3 expression is associated with greater survival in CRC patients and that B. uniformis-mediated protection is reliant on Lag-3 in innate cells. Induction of NK cell activity and reduced tumor growth is dependent on a specific B. uniformis capsular polysaccharide. Thus, healthy individuals possess tumor suppressor microbes that prevent cancer development and can be harnessed therapeutically.Article The Influence of The Bauhaus Approach on Industrial Ceramic Design(Anadolu Univ, 2025) Dogukan, HazalThe desire to move away from traditionalism caused by the intense discussions on art in the 19th and 20th centuries and to break traditional patterns that followed, initiated the search for new concepts, methods and techniques. In the Bauhaus School, the subjects of art and craft, form and meaning, aesthetics and function were reconsidered through different materials. Ceramics are also among the materials that gained a new meaning with Bauhaus. Before Bauhaus, ceramics, which were processed with detailed patterns and forms through handicraft and accepted as a traditional material, gained a modern and industrial identity in Bauhaus with standardized molds, forms suitable for function, far from processing and ornamentation. Bauhaus Ceramics Workshop has revealed approaches and methods that guide industrial ceramic design. The pots made by craftsmen have given way to minimal products designed with basic design principles and having a conceptual substructure. This innovation has formed the basis of the minimalism approach in today's industrial design. In line with the ideas and radical approach of the Bauhaus school, which started a new era for the field of design, this study aims to investigate the effects of the school on today's industrial ceramic product design, and many data found in the literature were used and content analysis was made on ceramic products made by Bauhaus artists. Bauhaus interpretations and reflections in industrial design were discussed. By presenting the Bauhaus references in ceramic product design, the study aims to contribute to the literature and offer a new perspective to researchers and designers in the field.Correction Citation - WoS: 11Measurement of Jet Multiplicity Distributions in T(t)over-Bar Production in pp Collisions at √s = 7 TeV (Vol 74, 3014, 2014)(Springer, 2015) Chatrchyan, S.; Khachatryan, V.; Sirunyan, A. M.; Tumasyan, A.; Adam, W.; Bergauer, T.; Woods, N.Conference Object The Semantic Categories in Teaching "If Clauses" in ESL Classes(Elsevier Science Bv, 2011) Bezircilioglu, SinemFor many second language learners, learning the target language is supposed to be identical with the mastery of the grammar of that language. When we say "the mastery of the grammar", we refer to the mastery of rules which revolve around the structure of the language. The problem arises at that point, actually. In this paper, this problem is going to be dwelled upon analysing a language item. As a matter of fact, this language item can be regarded as a symbol of the problem mentioned above. This language item is "if clauses". "If clauses" are not so easy to cope with since they require a mastery of some structure accompanied with an appropriate situation. The problem arises here, because a clear-cut distinction between the types and usage are not always possible. We ought not to forget that grammar is not the fundamental of the target language, which consists of the finely tuned structural prescriptions only. Language is meaningful as long as it is contextualized. We cannot take over the use of language if it is presented in isolated exercises having a meaningful context. Comprehensive exercises are essential to teach "if clauses". In conclusion, in this paper I intend to suggest a semantic classification of "if clauses" so as to avoid overgeneralization which is a result of the classification of "if clauses" structurally. Making this suggestion, I would like to support it with examples from the works of literature as well. If the classification of the language item in question is made semantically, the comprehension of the subject "if clauses" will be much better. (c) 2011 Published by Elsevier Ltd. Open access under CC BY-NC-ND license.Article Developing Examination Scheduling Automation System by Using Evolutionary Computing Technique(Pamukkale Univ, 2012) Yaldir, Abdulkadir; Baysal, CeydaIn this study, manually (paperwork) and periodically prepared exam scheduling applications at universities have been taken into a computer automation system by developing a software solution. In the software developed by the authors, Evolutionary Algorithm method has been applied and university administration's specific improvement requests have also been taken into consideration while developing the software. The developed software has two parts: First part is about collecting data through the web application, and the second part is the application project, which calculates the final scheduling results. By utilizing the software, a considerable amount of time lost by manually preparing exam schedules will be saved. In addition, with the real-time connection to the student automation system database, numerous problems will be vanished, i.e. students/classes exam scheduling conflicts, etc. In the study, tables added to the current student automation system database have been explained. Additionally, by applying the genetic algorithm methods to the various parts of data have been examined along with the constraints used in the application, which are essential parts of the software. User interfaces have been designed with their sample instances. Finally, exam-scheduling table has been created and an example output of the schedule has been generated in the study.Article Citation - WoS: 15Search for Supersymmetry in pp Collisions at √s=7 TeV in Events With a Single Lepton, Jets, and Missing Transverse Momentum(Springer, 2013) Chatrchyan, S.; Khachatryan, V.; Sirunyan, A. M.; Tumasyan, A.; Adam, W.; Aguilo, E.; Swanson, J.Results are reported from a search for new physics processes in events containing a single isolated high-transverse-momentum lepton (electron or muon), energetic jets, and large missing transverse momentum. The analysis is based on a 4.98 fb(-1) sample of proton-proton collisions at a center-of-mass energy of 7 TeV, obtained with the CMS detector at the LHC. Three separate background estimation methods, each relying primarily on control samples in the data, are applied to a range of signal regions, providing complementary approaches for estimating the background yields. The observed yields are consistent with the predicted standard model backgrounds. The results are interpreted in terms of limits on the parameter space for the constrained minimal supersymmetric extension of the standard model, as well as on cross sections for simplified models, which provide a generic description of the production and decay of new particles in specific, topology based final states.Article Citation - WoS: 36Search for Three-Jet Resonances in pp Collisions at √s=7 TeV(Elsevier, 2012) Chatrchyan, S.; Khachatryan, V.; Sirunyan, A. M.; Tumasyan, A.; Adam, W.; Aguilo, E.; Swanson, J.Results are reported from a search for the production of three-jet resonances in pp collisions at a center-of-mass energy root s = 7 TeV. The study uses the data sample collected by the CMS experiment at the LHC in 2011, corresponding to an integrated luminosity of 5.0 fb(-1). Events with high jet multiplicity and a large scalar sum of jet transverse momenta are analyzed for the presence of resonances in the three-jet invariant mass spectrum. No evidence for a narrow resonance is found in the data, and limits are set on the cross section for gluino pair production in an R-parity-violating supersymmetry model, for gluino masses greater than 280 GeV. Assuming a branching fraction for gluino decay into three jets of 100%, gluino masses below 460 GeV are excluded at 95% confidence level. These results significantly extend the range of previous limits. (C) 2012 CERN. Published by Elsevier By. All rights reserved.Review Domestic Devotions in the Early Modern World(Univ Art Assoc Canada, 2020) Andersen, Angela; Gunduz, CanArticle Role of Long Non-Coding RNA X-Inactive Transcript (XIST) in Neuroinflammation and Myelination: Insights From Cerebral Organoids and Implications for Multiple Sclerosis(MDPI, 2025) Pepe, Nihan Aktas; Acar, Busra; Zararsiz, Gozde Erturk; Guner, Serife Ayaz; Sen, AlaattinBackground/Objectives: X-inactive-specific transcript (XIST) is a factor that plays a role in neuroinflammation. This study investigated the role of XIST in neuronal development, neuroinflammation, myelination, and therapeutic responses within cerebral organoids in the context of Multiple Sclerosis (MS) pathogenesis. Methods: Human cerebral organoids with oligodendrocytes were produced from XIST-silenced H9 cells, and the mature organoids were subsequently treated with either FTY720 or DMF. Gene expression related to inflammation and myelination was subsequently analyzed via qRT-PCR. Immunofluorescence staining was used to assess the expression of proteins related to inflammation, myelination, and neuronal differentiation. Alpha-synuclein protein levels were also checked via ELISA. Finally, transcriptome analysis was conducted on the organoid samples. Results: XIST-silenced organoids presented a 2-fold increase in the expression of neuronal stem cells, excitatory neurons, microglia, and mature oligodendrocyte markers. In addition, XIST silencing increased IL-10 mRNA expression by 2-fold and MBP and PLP1 expression by 2.3- and 0.6-fold, respectively. Although XIST silencing tripled IBA1 protein expression, it did not affect organoid MBP expression. FTY720, but not DMF, distinguished MBP and IBA1 expression in XIST-silenced organoids. Furthermore, XIST silencing reduced the concentration of alpha-synuclein from 300 to 100 pg/mL, confirming its anti-inflammatory role. Transcriptomic and gene enrichment analyses revealed that the differentially expressed genes are involved in neural development and immune processes, suggesting the role of XIST in neuroinflammation. The silencing of XIST modified the expression of genes associated with inflammation, myelination, and neuronal growth in cerebral organoids, indicating a potential involvement in the pathogenesis of MS. Conclusions: XIST may contribute to the MS pathogenesis as well as neuroinflammatory diseases such as and Alzheimer's and Parkinson's diseases and may be a promising therapeutic target.