WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
Permanent URI for this collectionhttps://hdl.handle.net/11147/7150
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Article Citation - WoS: 1Citation - Scopus: 1Synthesis of Pristine Chitosan Foams with Enhanced Pore Structure, Surface Area, and Mechanical Strength for Tissue Engineering Applications(Iop Publishing Ltd, 2025) Polat, M.; Cropper, Chelsea; Ozdamar, A. B.; Polat, H.With its excellent biocompatibility, biodegradability, and antimicrobial activity, chitosan is a promising scaffold material for hard-tissue engineering. Yet, pristine chitosan foams typically lack the strength and porosity required for such use. Here we present a simple emulsion-templating approach to fabricate pristine chitosan foams with optimized strength and porosity. Sodium dodecyl sulfate (SDS), a widely used biocompatible anionic surfactant, was employed at trace levels to aid polymerization. The foams display a dual-scale pore morphology. Cavities of 150-300 mu m are separated by around 50 mu m thick chitosan walls containing large interconnecting openings. The walls are further populated with meso- and macropores of 50-500 nm. This architecture should support cell attachment and growth, facilitate proliferation, and enhance nutrient transport and metabolic exchange. The structure yields high surface area (up to 10 m2 g-1). Mechanically, the thick-walled cavities impart both elastic recovery and high compressive resistance (255 kPa at 40% strain from foams polymerized with 4% chitosan). A preliminary drug-release study using vancomycin confirmed excellent loading and sustained release.Article Machinability Investigation on Cnc Milling of Recycled Short Carbon Fiber Reinforced Magnesium Matrix Composites(Iop Publishing Ltd, 2024) Atasoy, Sahin; Kandemir, SinanThis study investigates the machinability of magnesium matrix composites reinforced with short carbon fibers, which represent novel materials in the field. AZ91 alloy and its composites containing 2.5 and 5 wt% recycled carbon fiber (rCF) reinforcements were used as workpieces. Face milling was conducted using uncoated carbide cutting tools under dry cutting conditions with varied cutting speeds (480-560-640 m min(-1)) and feed rates (0.65-0.8-0.95 mm min(-1)). The experimental design was based on the Taguchi L-9 (3(3)) orthogonal array. Analysis included cutting forces, surface roughness, wear on cutting inserts, and chip morphology to assess machinability. Taguchi, analysis of variance, and regression methods were employed to analyze cutting force and surface roughness results. Findings indicated satisfactory machinability for AZ91 alloy and comparatively poorer performance for the 5 wt% rCF reinforced composite, with increased reinforcement content correlating with higher cutting force and surface roughness. SEM and EDX analyses revealed significant built-up layer formation on cutting inserts, with predominantly spiral-shaped continuous chips observed in the experiments. Overall, the study affirmed the machinability of the composites and identified suitable cutting parameters for further investigations.Article Citation - WoS: 14Citation - Scopus: 163D Bioprinting of mouse pre-osteoblasts and human MSCs using bioinks consisting of gelatin and decellularized bone particles(Iop Publishing Ltd, 2024) Kara, Aylin; Distler, Thomas; Akkineni, Ashwini Rahul; Tihminlioglu, Funda; Gelinsky, Michael; Boccaccini, Aldo R.One of the key challenges in biofabrication applications is to obtain bioinks that provide a balance between printability, shape fidelity, cell viability, and tissue maturation. Decellularization methods allow the extraction of natural extracellular matrix, preserving tissue-specific matrix proteins. However, the critical challenge in bone decellularization is to preserve both organic (collagen, proteoglycans) and inorganic components (hydroxyapatite) to maintain the natural composition and functionality of bone. Besides, there is a need to investigate the effects of decellularized bone (DB) particles as a tissue-based additive in bioink formulation to develop functional bioinks. Here we evaluated the effect of incorporating DB particles of different sizes (<= 45 and <= 100 mu m) and concentrations (1%, 5%, 10% (wt %)) into bioink formulations containing gelatin (GEL) and pre-osteoblasts (MC3T3-E1) or human mesenchymal stem cells (hTERT-MSCs). In addition, we propose a minimalistic bioink formulation using GEL, DB particles and cells with an easy preparation process resulting in a high cell viability. The printability properties of the inks were evaluated. Additionally, rheological properties were determined with shear thinning and thixotropy tests. The bioprinted constructs were cultured for 28 days. The viability, proliferation, and osteogenic differentiation capacity of cells were evaluated using biochemical assays and fluorescence microscopy. The incorporation of DB particles enhanced cell proliferation and osteogenic differentiation capacity which might be due to the natural collagen and hydroxyapatite content of DB particles. Alkaline phosphatase activity is increased significantly by using DB particles, notably, without an osteogenic induction of the cells. Moreover, fluorescence images display pronounced cell-material interaction and cell attachment inside the constructs. With these promising results, the present minimalistic bioink formulation is envisioned as a potential candidate for bone tissue engineering as a clinically translatable material with straightforward preparation and high cell activity.Article Citation - WoS: 3Citation - Scopus: 4Patient-Specific Finite Element Analysis for Assessing Hip Fracture Risk in Aging Populations(Iop Publishing Ltd, 2024) Chethan, K. N.; Waldschmidt, Nadine Schmidt Genannt; Corda, John Valerian; Shenoy, Satish B.; Shetty, Sawan; Keni, Laxmikant G.; Mihcin, SenayThe femur is one of the most important bone in the human body, as it supports the body's weight and helps with movement. The aging global population presents a significant challenge, leading to an increasing demand for artificial joints, particularly in knee and hip replacements, which are among the most prevalent surgical procedures worldwide. This study focuses on hip fractures, a common consequence of osteoporotic fractures in the elderly population. To accurately predict individual bone properties and assess fracture risk, patient-specific finite element models (FEM) were developed using CT data from healthy male individuals. The study employed ANSYS 2023 R2 software to estimate fracture loads under simulated single stance loading conditions, considering strain-based failure criteria. The FEM bone models underwent meticulous reconstruction, incorporating geometrical and mechanical properties crucial for fracture risk assessment. Results revealed an underestimation of the ultimate bearing capacity of bones, indicating potential fractures even during routine activities. The study explored variations in bone density, failure loads, and density/load ratios among different specimens, emphasizing the complexity of bone strength determination. Discussion of findings highlighted discrepancies between simulation results and previous studies, suggesting the need for optimization in modelling approaches. The strain-based yield criterion proved accurate in predicting fracture initiation but required adjustments for better load predictions. The study underscores the importance of refining density-elasticity relationships, investigating boundary conditions, and optimizing models through in vitro testing for enhanced clinical applicability in assessing hip fracture risk. In conclusion, this research contributes valuable insights into developing patient-specific FEM bone models for clinical hip fracture risk assessment, emphasizing the need for further refinement and optimization for accurate predictions and enhanced clinical utility.Article Citation - WoS: 36Citation - Scopus: 37Microwave Control of Rydberg Atom Interactions(Iop Publishing Ltd, 2014) Sevinçli, Sevilay; Pohl, T.We investigate the interaction between Rydberg atoms, whose electronic states are dressed by multiple microwave fields. Numerical calculations are used for an exact description of the microwave induced interactions, and employed to benchmark a perturbative treatment that yields simple insights into the involved mechanisms. Based on this theory, we demonstrate that microwave dressing provides a powerful approach to control dipolar as well as van der Waals interactions and even permits us to turn them off entirely. In addition, the proposed scheme also opens up possibilities for engineering dominant three-body interactions.Conference Object Citation - WoS: 6Citation - Scopus: 13A Methodology for Daylight Optimisation of High-Rise Buildings in the Dense Urban District Using Overhang Length and Glazing Type Variables With Surrogate Modelling(Iop Publishing Ltd, 2019) Ekici, Berk; Kazanasmaz, Zehra Tuğçe; Turrin, Michela; Taşgetiren, M. Fatih; Sarıyıldız, I. SevilUrbanization and population growth lead to the construction of higher buildings in the 21st century. This causes an increment on energy consumption as the amount of constructed floor areas is rising steadily. Integrating daylight performance in building design supports reducing the energy consumption and satisfying occupants' comfort. This study presents a methodology to optimise the daylight performance of a high-rise building located in a dense urban district. The purpose is to deal with optimisation problems by dividing the high-rise building into five zones from the ground level to the sky level, to achieve better daylight performance. Therefore, the study covers five optimization problems. Overhang length and glazing type are considered to optimise spatial Daylight Autonomy (sDA) and Annual Sunlight Exposure (ASE). A total of 500 samples in each zone are collected to develop surrogate models. A self-adaptive differential evolution algorithm is used to obtain near-optimal results for each zone. The developed surrogate models can estimate the metrics with minimum 98.25% R2 which is calculated from neural network prediction and Diva simulations. In the case study, the proposed methodology improves daylight performance of the high-rise building, decreasing ASE by approx. 27.6% and increasing the sDA values by around 88.2% in the dense urban district. © Published under licence by IOP Publishing Ltd.