WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
Permanent URI for this collectionhttps://hdl.handle.net/11147/7150
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Conference Object Citation - WoS: 24Effect of pH and Hydration on the Normal and Lateral Interaction Forces Between Alumina Surfaces(2006) Polat, Mehmet; Sato, Kimiyasu; Nagaoka, Takaaki; Watari, KojiNormal and lateral interaction forces between alumina surfaces were measured using Atomic Force Microscopy-Colloid Probe Method at different pH. The normal force curves exhibit a well-defined repulsive barrier and an attractive minimum at acidic pH and the DLVO theory shows excellent agreement with the data. The normal forces are always repulsive at basic pH and the theory fails to represent the measurements. Lateral forces are almost an order of magnitude smaller in the basic solutions. These differences, which have important implications in the study of stability and rheology, are attributed to the hydration of the alumina surface at basic pH. © 2013 Elsevier B.V., All rights reserved.Conference Object Problem of Cracked Infinite Hollow Cylinder With Two Rigid Inclusions(Civil Comp Press, 2000) Artem, HSA; Gecit, MRThis paper is concerned with the fracture of an axisymmetric hollow cylindrical bar containing rigid inclusions. The cylinder is under the action of uniformly distributed axial tension applied at infinity. The hollow cylinder contains a ring-shaped crack at the symmetry plane whose surfaces are free of tractions and two ring-shaped rigid inclusions with negligible thickness symmetrically located on both sides of the crack. Geometry and the loading is symmetric about z-axis. Along the rigid inclusions displacements are constant and continuous whereas stresses have jumps. The inner and the outer surfaces of the cylinder are free of tractions It is assumed that the material of the cylinder is linearly elastic and isotropic. The mixed boundary conditions of the problem lead the analysis to a system of three singular integral equations for crack surface displacement derivative and normal and shear stress jumps on rigid inclusions. These integral equations are solved numerically and the stress intensity factors at the edges of the crack and at the edges of the inclusions are calculated. Results are presented in graphical form.Conference Object Nanoscale Surface Modification of Ultrahigh Molecular Weight Polyethylene (UHMWPE) Samples With the W Plus C Ion Implantation(Materials Research Soc, 2007) Urkac, E. Sokullu; Oztarhan, A.; Tihminlioglu, F.; Kaya, N.; Budak, S.; Chhay, B.; Ila, D.In this work, Ultra High Molecular Weight Poly Ethylene (UHMWPE) samples Were implanted by W + C ions using Metal-Vapour Vacuum Arc (MEVVA) ion implantation system with a fluence of 10(17) ion/cm(2) and extraction voltage of 30 kV. Samples were characterized with Raman Spectra, ATR-FTIR, UV-VIS-NlR Spectrum and RBS. Surface morphology of implanted and unimplanted samples were examined in nanoscale with AFM.Article Citation - WoS: 37Mechanisms of Cellular Resistance To Imatinib in Human Chronic Myeloid Leukemia Cells(Taylor and Francis Ltd., 2007) Baran, Yusuf; Ural, Ali Uğur; Gündüz, UfukA major advancement in the treatment of chronic myeloid leukemia (CML) has been the development of imatinib, which has shown striking activity in the chronic phase and the accelerated phase, but less so in the blast phase of the disease. Despite high rates of hematologic and cytogenetic responses to therapy, the emergence of resistance to imatinib has been recognized as a major problem in the treatment of patients with CML. Various cellular mechanisms may be involved in the nature of cellular resistance. Increased amount of target, alteration in structure of target proteins, decreased drug uptake and increased detoxification are well-known mechanisms of resistance. On the other hand, in some cases, even if anticancer drugs reach their sites of action, bypassing drug efflux system of the cells, some cells still may survive via the dysregulation of apoptotic signalling. In this study, mechanisms of resistance to imatinib-induced apoptosis in human Meg-01 CML cells were examined. Continuous exposure of cells to step-wise increasing concentrations of imatinib resulted in the selection of 200- and 1000 nM imatinib-resistant sub-lines referred to as Meg-01/IMA-0,2 and Meg-01/1MA-1, respectively. MTT cell proliferation, cell cycle analyses and trypan blue dye exclusion analyses showed that Meg-0l/IMA-1 cells were resistant to imatinib-induced apoptosis as compared to parental sensitive cells. There was an increased expression of BCR/ABL, Bcl-2 and an increase in mitochondrial membrane potential (MMP) detected in resistant cells comparing to parental sensitive cells. There was no mutation detected in imatinib binding site of ABL kinase region. Various diverse mechanisms have been reported for their involvement in the multidrug resistance. In this study, it has been shown that the degree of BCR/ABL expression appears to be directly proportional to the levels of imatinib resistance. In addition, there have been BCR/ABL-independent mechanisms reported for deriving resistance against imatinib. Our results revealed that besides BCR/ABL overexpression, imatinib resistance also depends on the inhibition of apoptosis as a result of up-regulation of anti-apoptotic stimuli and down-regulation of pro-apoptotic stimuli through MMP but does not depend on any mutation on imatinib binding site of ABL kinase.Article Citation - WoS: 13Citation - Scopus: 15Design, Performance, and Calibration of the Cms Hadron-Outer Calorimeter(Springer Verlag, 2008) Karapınar, GülerThe Outer Hadron Calorimeter (HCAL HO) of the CMS detector is designed to measure the energy that is not contained by the barrel (HCAL HB) and electromagnetic (ECAL EB) calorimeters. Due to space limitation the barrel calorimeters do not contain completely the hadronic shower and an outer calorimeter (HO) was designed, constructed and inserted in the muon system of CMS to measure the energy leakage. Testing and calibration of the HO was carried out in a 300 GeV/c test beam that improved the linearity and resolution. HO will provide a net improvement in missing E T measurements at LHC energies. Information from HO will also be used for the muon trigger in CMS. © 2008 Springer-Verlag / Società Italiana di Fisica.Conference Object A Boundary Element Method for Axisymmetric Elastodynamic Analysis(John Wiley and Sons Inc., 1996) Özkan, Gonca; Mengi, YalçınA new numerical method is proposed for the boundary element analysis of axisymmetric bodies. The method is based on complex Fourier series expansion of boundary quantities in circumferential direction, which reduced the boundary element equation to an integral equation in (r-z) plane involving the Fourier coefficients of boundary quantities, where r and z are the coordinates of the r theta z cylindrical coordinate system. The kernels appearing in these integral equations can be computed effectively by discrete Fourier transform formulas together with the fast Fourier transform (FFT) algorithm, and the integral equations (r-z) plane can be solved by Gaussian quadrature, which establishes the Fourier coefficients associated with boundary quantities. The Fourier transform solution can then be inverted into r theta z space by using again discrete Fourier transform formulas together with FFT algorithm. In this paper, we present the formulation of the proposed method which is outlined above. A comparison is given between the existent methods in literature and our method, which shows that the use of FFT algorithm for the integrations in circumferential direction provides considerable saving in computer time.Conference Object Optimization of Mass Spectrometric Ionisation Efficiency Data(Springer Verlag, 1997) Özgen, İsmet Tamerkan; Altungöz, Oya; Salih, B.; Vandeginste, B. G. M.A new method is developed and tested to find out the excited electronic and vibrational energy levels (fine structure) of molecules from mass spectrometric ionisation efficiency data which were obtained by a conventional mass spectrometer ion source having normal electron energy distribution. Electrons emitted in a conventional mass spectrometer ion source are not monoenergetic, therefore, evaluation of Ionisation Potentials (IF) and Appearance Potentials (AP) from experimental data creates some problems. This is even worse in the evaluation of Fine Structure (excited electronic and vibrational energy levels) from ionisation efficiency data [1]. This is overcome either by using specially designed monoenergetic ion sources which have their own problems (manufacture of special design, difficulty of operation, too much decrease of ion current), or by eliminating disturbing effects in the ionisation efficiency data by some deconvolution techniques [2,4,5,6,7,9]. In this study attempts were made to eliminate the deteriorating effects (mainly arising from electron energy distribution and noise) in the ionisation efficiency data by a deconvolution technique. The technique was applied to the ionisation efficiency data of molecular nitrogen,oxygen and methylammine and its fragment and interesting results were obtained.Conference Object Problem of Cracked Infinite Hollow Cylinder With Two Rigid Inclusions(Civil-Comp Press, 2000) Artem, Hatice Seçil; Geçit, Mehmet RuşenThis paper is concerned with the fracture of an axisymmetric hollow cylindrical bar containing rigid inclusions. The cylinder is under the action of uniformly distributed axial tension applied at infinity. The hollow cylinder contains a ring-shaped crack at the symmetry plane whose surfaces are free of tractions and two ring-shaped rigid inclusions with negligible thickness symmetrically located on both sides of the crack. Geometry and the loading is symmetric about z-axis. Along the rigid inclusions displacements are constant and continuous whereas stresses have jumps. The inner and the outer surfaces of the cylinder are free of tractions It is assumed that the material of the cylinder is linearly elastic and isotropic. The mixed boundary conditions of the problem lead the analysis to a system of three singular integral equations for crack surface displacement derivative and normal and shear stress jumps on rigid inclusions. These integral equations are solved numerically and the stress intensity factors at the edges of the crack and at the edges of the inclusions are calculated. Results are presented in graphical form.Conference Object Effect of Some Physical, and Chemical Variables on Flocculation and Sediment Behaviour(A.A. Balkema Publishers, 2000) Polat, Hürriyet; Polat, Mehmet; İpekoğlu, ÜnerEffect of some chemical and physical variables on the settling rate, final sediment height, sediment viscosity and supernatant turbidity of a clay sample was studied using various polyacrylamide type flocculants. Increasing flocculant concentration significantly increased both the settling rate and sediment viscosity. More importantly, changes in the final sediment, height, hence the packing density, was minimal for all the conditions tested once the sediment was allowed to consolidate. Also, the mode of addition of the polymer, at once or continuous, did not seem to affect any of the parameters measured. Conditioning time seemed to alter the settling rate at low polymer concentrations, but had no effect at high polymer concentrations. However, increasing the conditioning time caused a decrease in the sediment viscosity. Different types of the polyacrylimides generated different settling rates at a given concentration, but the final sediment height was nearly independent of polymer type.Conference Object Predicting Drying in Solvent-Coated Polymeric Films(American Chemical Society, 2000) Alsoy Altınkaya, Sacide; Duda, John Larry[No abstract available]