WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
Permanent URI for this collectionhttps://hdl.handle.net/11147/7150
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Review Citation - WoS: 4Citation - Scopus: 7Optimizing Lighting Design in Educational Settings for Enhanced Cognitive Performance: a Literature Review(Elsevier Science Sa, 2025) Celik, Meric; Didikoglu, Altug; Kazanasmaz, TugceLighting has more functions than simply illuminating spaces. For humans, light is the main signal that aligns our body's internal clock, regulating circadian rhythms. This process instructs our bodies to wake up in the morning, become alert during the day, and feel sleepy at night. Disruption of these rhythms can impact neurological and psychiatric health, including cognitive performance. We can utilize light for mood improvements and better cognitive performance to create a suitable learning environment for students in educational buildings. These non-visual effects of light need to be considered from the beginning of the design process, making an interdisciplinary effort necessary. Even with adequate light and dark, the human eye reacts differently under various conditions, influenced by light's photometric and colorimetric properties. While natural sunlight is ideal for aligning with our biological clock, it is not always sufficient, making artificial lighting essential indoors. LED technology offers promising solutions, catering to our non-visual needs in the absence of natural light and providing energy efficiency. This study reviews the literature that includes students' cognitive performance and well-being, energy efficiency, running costs, and environment-related issues such as light pollution. It aims to explore the impact of lighting design in learning environments.Article Citation - WoS: 9Citation - Scopus: 8Depression in Older Adults and Its Associations With Sleep and Synaptic Density(Elsevier, 2024) Didikoglu, Altug; Guler, Esin Simge; Turk, Halil Kaan; Can, Kubilay; Erim, Aleyna Nur; Payton, Antony; Maharani, AsriBackground: Depression among older adults is a global concern, contributing to disability and overall illness burden. Understanding its trajectory, associated risk factors, and implications for mortality is essential for effective intervention. Moreover, the relationship between depression, sleep disturbances, and synaptic density in the ageing brain remains complex and poorly understood. Methods: Using data from the University of Manchester Longitudinal Study of Cognition in Normal Healthy Old Age cohort, comprising 6375 participants, we conducted comprehensive assessments of depression trajectories using generalized linear mixed models and mortality risks using Cox mixed-effects models. Generalized structural equation modelling was performed to explore longitudinal associations between sleep duration and depression. Lastly, associations between post-mortem synaptic density and depression were investigated. Results: Our findings revealed that depression rates declined until age 80 before increasing again. Depression was associated with a 10 % increased risk of mortality in older adults. Reduced sleep was correlated with depression, and depression measured early in the study predicted future reduced sleep. Post-mortem analysis showed a global reduction in synaptic density associated with depression, particularly pronounced in the frontal lobe. Limitations: Limitations include recall bias, limiting generalizability due to dominantly including White British participants and difficulty in establishing causation between synaptic density and depression. Conclusion: Our study underscores the significance of addressing depression in older adults, not only for mental health but also for mortality risk and neurobiological health. Early detection and intervention strategies are crucial for improving outcomes in elderly populations, potentially mitigating adverse effects on sleep, synaptic density, cognitive health, and longevity.Article Citation - WoS: 33Citation - Scopus: 30Associations Between Light Exposure and Sleep Timing and Sleepiness While Awake in a Sample of Uk Adults in Everyday Life(Natl Acad Sciences, 2023) Didikoglu, Altug; Mohammadian, Navid; Johnson, Sheena; van Tongeren, Martie; Wright, Paul; Casson, Alexander J.; Lucas, Robert J.; Didikoğlu, AltuğExperimental and interventional studies show that light can regulate sleep timing and sleepiness while awake by setting the phase of circadian rhythms and supporting alertness. The extent to which differences in light exposure explain variations in sleep and sleepiness within and between individuals in everyday life remains less clear. Here, we establish a method to address this deficit, incorporating an open- source wearable wrist -worn light logger (SpectraWear) and smartphone-based online data collection. We use it to simultaneously record longitudinal light exposure (in melanopic equivalent daylight illuminance), sleep timing, and subjective alertness over seven days in a convenience sample of 59 UK adults without externally imposed circadian challenge (e.g., shift work or jetlag). Participants reliably had strong daily rhythms in light exposure but frequently were exposed to less light during the daytime and more light in pre- bedtime and sleep episodes than recommended [T. M. Brown et al., PLoS Biol. 20, e3001571 (2022)]. Prior light exposure over several hours was associated with lower subjective sleepiness with, in particular, brighter light in the late sleep episode and after wake linked to reduced early morning sleepiness (sleep inertia). Higher pre- bedtime light exposure was associated with longer sleep onset latency. Early sleep timing was correlated with more reproducible and robust daily patterns of light exposure and higher daytime/lower night -time light exposure. Our study establishes a method for collecting longitudinal sleep and health/performance data in everyday life and provides evidence of associations between light exposure and important determinants of sleep health and performance.