WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

Permanent URI for this collectionhttps://hdl.handle.net/11147/7150

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Now showing 1 - 10 of 2861
  • Article
    A Capsular Polysaccharide from a Healthy Human Microbiota Member Activates a Lag-3-NK Cell Axis to Restrain Colon Cancer and Augment Immunotherapy
    (Cell Press, 2025) Weis, Allison M.; Tang, William W.; Stephen-Victor, Emmanuel; Bell, Rickesha; Brown, D. Garrett; Round, June L.
    Colorectal cancer (CRC) is increasing globally, making identification of preventative measures necessary. Transplantation of the microbiota from CRC and non-CRC patients into mice demonstrates that non-diseased individuals possess organisms that reduce tumor formation and highlights Bacteriodes uniformis as protective. B. uniformis is reduced in humans with CRC, and proactive treatment with B. uniformis slows tumor growth in mice. Natural killer (NK) cells, but not T cells, are required for B. uniformis-mediated protection. CRC is recalcitrant to immunotherapies; however, addition of B. uniformis restores response to alpha-CTLA-4 treatment in an NK cell-dependent manner. We report that high Lag-3 expression is associated with greater survival in CRC patients and that B. uniformis-mediated protection is reliant on Lag-3 in innate cells. Induction of NK cell activity and reduced tumor growth is dependent on a specific B. uniformis capsular polysaccharide. Thus, healthy individuals possess tumor suppressor microbes that prevent cancer development and can be harnessed therapeutically.
  • Article
    Citation - WoS: 1
    Citation - Scopus: 1
    Reconfigurable Polyhedral Mechanisms Using Scissor-Like Elements with Cantellation Transformation Between Dual Geometries
    (Pergamon-Elsevier Science Ltd, 2025) Liao, Yuan; Kiper, Gokhan; Krishnan, Sudarshan
    Deployable polyhedron mechanisms (DPMs) have garnered significant interest in architecture, aerospace, and robotics, where reconfigurable and space-efficient structures are crucial. This paper presents a tangential design method for DPMs using scissor-like elements (SLEs). Scissor units are placed along the edges of an equilateral polyhedron, tangential to its midsphere. This method enables the mechanisms to transform between a polyhedron and its dual, following the cantellation operation. Using screw theory, the kinematic properties of these mechanisms are analyzed. Results show that the DPMs exhibit 1-degree of freedom (DOF) under normal conditions and gain additional DOFs at multifurcation points, allowing for reconfigurable motion modes. Physical models based on various geometries, including Platonic, Archimedean, Johnson, and Catalan solids, help to validate the method's feasibility. Observations indicate that this method is only applicable to equilateral supporting polyhedra. The transformability and reconfigurability observed in these mechanisms demonstrate the potential of this approach for applications in architecture, aerospace, and robotics.
  • Article
    Making Hierarchically Aware Decisions on Short Findings for Automatic Summarisation
    (Elsevier, 2025) Inan, Emrah
    An impression in a typical radiology report emphasises critical information by providing a conclusion and reasoning based on the findings. However, the findings and impression sections of these reports generally contain brief texts, as they highlight crucial observations derived from the clinical radiograph. In this scenario, abstractive summarisation models often experience a degradation in performance when generating short impressions. To address this challenge in the summarisation task, our work proposes a method that combines well-known fine-tuned text classification and abstractive summarisation language models. Since fine-tuning a language model requires an extensive, well-defined training dataset and is a time-consuming task dependent on high GPU resources, we employ prompt engineering, which uses prompt templates to programme language models and improve their performance. Our method first predicts whether the given findings text is normal or abnormal by leveraging a fine-tuned language model. Then, we apply a radiology-specific BART model to generate the summary for abnormal findings. In the zero-shot setting, our method achieves remarkable results compared to existing approaches on a real-world dataset. In particular, our method achieves scores of 37.43 for ROUGE-1, 21.72 for ROUGE-2, and 35.52 for ROUGE-L.
  • Article
    A Critical Analysis of Pulverization Mechanism During Hydrogen Decrepitation of End-Of Ndfeb Magnets
    (Elsevier Science Sa, 2025) Habibzadeh, Alireza; Gokelma, Mertol
    Given the increasing demand and limited availability of rare earth elements (REEs), innovative solutions are critical to managing supply risks. Recycling is a key strategy in mitigating these risks, particularly for NdFeB magnets, which consume a large portion of REEs. Among the various recycling processes, hydrogen decrepitation (HD) has gained popularity due to its efficiency in producing fine powders for magnet-to-magnet recycling. While the HD mechanism is commonly attributed to hydride formation in the Nd-rich grain boundary phase, this study presents new findings that challenge this assumption. Through the hydrogenation of End-of-Life (EoL) NdFeB magnets at temperatures ranging from 25 to 400 & ring;C, the results indicate that the primary mechanism of pulverization arises from hydride formation in the Nd2Fe14B matrix rather than in the Nd-rich phase, especially at low temperatures where NdH2 formation is kinetically unfavorable. This revised mechanism was supported by evidence from X-ray diffraction, BSE and SE-SEM imaging, particle size analysis, diffusion modeling, and stress analysis.
  • Article
    Citation - WoS: 7
    Design Education for Adaptive Reuse
    (Archnet-ijar, 2010) Eyuce, Ozen; Eyuce, Ahmet
    Builtform is subject to various types of obsolences in the course of time. Among these functional obsolesences, taking place as an outcome of ever changing modes of production and consumption, are of crucial importance so far as their fate of existing urban fabric is concerned. Defunct buildings become derelict and often subject to demolition which amounts to the eradication of the collective memory. In this connection the process of adaptive reuse can be defined as the task of adjusting functionally obsolete buildings for new program requirements through building conversion. Adaptive reuse projects entail not only alterations within the boundaries of an existing building envolope but also radical changes/transformations in the space configuration so as to accomodate the new set of functional requirements. Therefore, the development of an architectural design scheme in the light of potentials offered and the constraints imposed by an existing architectural entity is essential. Although adaptive reuse projects require case specific approaches depending on the peculiarities of the original structure three main areas of concern can be discerned during the elaboration of the design scheme. These areas of concerns are the space configuration, tectonic aspects of the context within which the project will be realized. The paper addresses itself to the elucidation of these concern areas and the interrelations with the final scheme.
  • Conference Object
    Imatinib-Induced Apoptosis; a Possible Link To Topoisomerase Enzyme Inhibition
    (Ferrata Storti Foundation, 2010) Baran, Y.; Zencir, Z.; Cakir, Z.; Ozturk, E.; Topcu, Z.
  • Article
    Citation - WoS: 3
    Citation - Scopus: 3
    A Novel Hybrid Thin Jacketing Method for Seismic Retrofitting of Substandard Reinforced Concrete Columns
    (Elsevier Ltd, 2025) Narlitepe, Furkan; Kian, Nima; Demir, Ugur; Demir, Cem; Ilki, Alper
    This paper introduces a novel hybrid thin jacketing method for seismic strengthening of substandard reinforced concrete (RC) columns for which structural repair mortar along with carbon fiber reinforced polymer (CFRP) and longitudinal steel bars are utilized. The method involves three application phases comprising a) removing the cover concrete, b) re-forming the cover concrete with structural repair mortar just after installing extra longitudinal steel bars c) transverse wrapping of CFRP sheets. The effect of using different types of structural repair mortar and its application process are other test parameters taken into account in this study. To evaluate the efficacy of the proposed method, a comprehensive experimental program was conducted, consisting of six largescale RC column specimens with square and rectangular cross-sections. For all of the specimens tested under a simultaneous constant axial load and reversed cyclic lateral loading, three main properties representing existing substandard RC columns such as a) insufficient transverse reinforcement, b) high axial load ratio (0.75) and, c) relatively high shear force corresponding to moment capacity to shear capacity ratios between 0.60 and 0.80, were considered. The responses of specimens were specified in terms of the lateral load-displacement curves, stiffness variation, ductility ratios, damage progression, and energy dissipation. The experimental results demonstrated that in case the retrofitting method is properly applied, the strengthened columns exhibit satisfactory performance in terms of strength and ductility with a remarkable improvement with respect to the substandard columns. Furthermore, a numerical study was conducted to validate the experimental results by using the OpenSees framework.
  • Article
    Influence of Fluorine on Structural and Electrical Properties of VO2 Thin Films Deposited by Magnetron Sputtering
    (Elsevier Ltd, 2025) Akyurek, Bora; Cantas, Ayten; Demirhan, Yasemin; Ozyuzer, Lutfi; Aygun, Gulnur
    This study investigates whether fluorine-based thermal gel used during electrical measurements of vanadium oxide (VO2) films influences the structural, morphological, or compositional integrity of the films. High-quality VO2 films with a resistance ratio change of about 10(4) for metal-insulator transition were deposited by magnetron sputtering. During electrical characterization, VO2 film was heated from room temperature to similar to 370 K with a fluorine-based thermal gel usage to achieve better heat contact between the film and substrate holder. Structural and chemical properties were assessed through XRD, Raman, XPS, SEM, and energy dispersive spectroscopy imaging. XRD revealed diffraction peaks consistent with monoclinic VO2 confirming that the crystal lattice remains the same although fluorine based thermal gel was used. Raman spectra exhibited vibrational modes indicating that the phonon structure of VO2 was preserved despite fluorine gel usage. XPS results showed only a minor F 1s signal (2.8%) limited only to the film surface. SEM and EDS analyses further confirmed that surface morphology and elemental composition remained belonging to VO2 film. These findings demonstrate that the usage of fluorine-based thermal gel results in only a minimal surface interaction, thereby preserving intrinsic material properties of VO2 and supporting a potential usage for future device fabrication applications.
  • Correction
    Citation - WoS: 11
    Measurement of Jet Multiplicity Distributions in T(t)over-Bar Production in pp Collisions at √s = 7 TeV (Vol 74, 3014, 2014)
    (Springer, 2015) Chatrchyan, S.; Khachatryan, V.; Sirunyan, A. M.; Tumasyan, A.; Adam, W.; Bergauer, T.; Woods, N.
  • Conference Object
    Modeling of Glycolysis
    (Elsevier Science Bv, 2016) Batur, Aysem; Hamamci, Haluk; Buyukkileci (Sahin), Ceylan; Buyukkileci, Ali Oguz