WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

Permanent URI for this collectionhttps://hdl.handle.net/11147/7150

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Now showing 1 - 10 of 2503
  • Article
    A Capsular Polysaccharide from a Healthy Human Microbiota Member Activates a Lag-3-NK Cell Axis to Restrain Colon Cancer and Augment Immunotherapy
    (Cell Press, 2025) Weis, Allison M.; Tang, William W.; Stephen-Victor, Emmanuel; Bell, Rickesha; Brown, D. Garrett; Round, June L.
    Colorectal cancer (CRC) is increasing globally, making identification of preventative measures necessary. Transplantation of the microbiota from CRC and non-CRC patients into mice demonstrates that non-diseased individuals possess organisms that reduce tumor formation and highlights Bacteriodes uniformis as protective. B. uniformis is reduced in humans with CRC, and proactive treatment with B. uniformis slows tumor growth in mice. Natural killer (NK) cells, but not T cells, are required for B. uniformis-mediated protection. CRC is recalcitrant to immunotherapies; however, addition of B. uniformis restores response to alpha-CTLA-4 treatment in an NK cell-dependent manner. We report that high Lag-3 expression is associated with greater survival in CRC patients and that B. uniformis-mediated protection is reliant on Lag-3 in innate cells. Induction of NK cell activity and reduced tumor growth is dependent on a specific B. uniformis capsular polysaccharide. Thus, healthy individuals possess tumor suppressor microbes that prevent cancer development and can be harnessed therapeutically.
  • Article
    Citation - WoS: 1
    Citation - Scopus: 1
    Reconfigurable Polyhedral Mechanisms Using Scissor-Like Elements with Cantellation Transformation Between Dual Geometries
    (Pergamon-Elsevier Science Ltd, 2025) Liao, Yuan; Kiper, Gokhan; Krishnan, Sudarshan
    Deployable polyhedron mechanisms (DPMs) have garnered significant interest in architecture, aerospace, and robotics, where reconfigurable and space-efficient structures are crucial. This paper presents a tangential design method for DPMs using scissor-like elements (SLEs). Scissor units are placed along the edges of an equilateral polyhedron, tangential to its midsphere. This method enables the mechanisms to transform between a polyhedron and its dual, following the cantellation operation. Using screw theory, the kinematic properties of these mechanisms are analyzed. Results show that the DPMs exhibit 1-degree of freedom (DOF) under normal conditions and gain additional DOFs at multifurcation points, allowing for reconfigurable motion modes. Physical models based on various geometries, including Platonic, Archimedean, Johnson, and Catalan solids, help to validate the method's feasibility. Observations indicate that this method is only applicable to equilateral supporting polyhedra. The transformability and reconfigurability observed in these mechanisms demonstrate the potential of this approach for applications in architecture, aerospace, and robotics.
  • Article
    Making Hierarchically Aware Decisions on Short Findings for Automatic Summarisation
    (Elsevier, 2025) Inan, Emrah
    An impression in a typical radiology report emphasises critical information by providing a conclusion and reasoning based on the findings. However, the findings and impression sections of these reports generally contain brief texts, as they highlight crucial observations derived from the clinical radiograph. In this scenario, abstractive summarisation models often experience a degradation in performance when generating short impressions. To address this challenge in the summarisation task, our work proposes a method that combines well-known fine-tuned text classification and abstractive summarisation language models. Since fine-tuning a language model requires an extensive, well-defined training dataset and is a time-consuming task dependent on high GPU resources, we employ prompt engineering, which uses prompt templates to programme language models and improve their performance. Our method first predicts whether the given findings text is normal or abnormal by leveraging a fine-tuned language model. Then, we apply a radiology-specific BART model to generate the summary for abnormal findings. In the zero-shot setting, our method achieves remarkable results compared to existing approaches on a real-world dataset. In particular, our method achieves scores of 37.43 for ROUGE-1, 21.72 for ROUGE-2, and 35.52 for ROUGE-L.
  • Article
    A Critical Analysis of Pulverization Mechanism During Hydrogen Decrepitation of End-Of Ndfeb Magnets
    (Elsevier Science Sa, 2025) Habibzadeh, Alireza; Gokelma, Mertol
    Given the increasing demand and limited availability of rare earth elements (REEs), innovative solutions are critical to managing supply risks. Recycling is a key strategy in mitigating these risks, particularly for NdFeB magnets, which consume a large portion of REEs. Among the various recycling processes, hydrogen decrepitation (HD) has gained popularity due to its efficiency in producing fine powders for magnet-to-magnet recycling. While the HD mechanism is commonly attributed to hydride formation in the Nd-rich grain boundary phase, this study presents new findings that challenge this assumption. Through the hydrogenation of End-of-Life (EoL) NdFeB magnets at temperatures ranging from 25 to 400 & ring;C, the results indicate that the primary mechanism of pulverization arises from hydride formation in the Nd2Fe14B matrix rather than in the Nd-rich phase, especially at low temperatures where NdH2 formation is kinetically unfavorable. This revised mechanism was supported by evidence from X-ray diffraction, BSE and SE-SEM imaging, particle size analysis, diffusion modeling, and stress analysis.
  • Conference Object
    Imatinib-Induced Apoptosis; a Possible Link To Topoisomerase Enzyme Inhibition
    (Ferrata Storti Foundation, 2010) Baran, Y.; Zencir, Z.; Cakir, Z.; Ozturk, E.; Topcu, Z.
  • Article
    Citation - WoS: 3
    Citation - Scopus: 3
    A Novel Hybrid Thin Jacketing Method for Seismic Retrofitting of Substandard Reinforced Concrete Columns
    (Elsevier Ltd, 2025) Narlitepe, Furkan; Kian, Nima; Demir, Ugur; Demir, Cem; Ilki, Alper
    This paper introduces a novel hybrid thin jacketing method for seismic strengthening of substandard reinforced concrete (RC) columns for which structural repair mortar along with carbon fiber reinforced polymer (CFRP) and longitudinal steel bars are utilized. The method involves three application phases comprising a) removing the cover concrete, b) re-forming the cover concrete with structural repair mortar just after installing extra longitudinal steel bars c) transverse wrapping of CFRP sheets. The effect of using different types of structural repair mortar and its application process are other test parameters taken into account in this study. To evaluate the efficacy of the proposed method, a comprehensive experimental program was conducted, consisting of six largescale RC column specimens with square and rectangular cross-sections. For all of the specimens tested under a simultaneous constant axial load and reversed cyclic lateral loading, three main properties representing existing substandard RC columns such as a) insufficient transverse reinforcement, b) high axial load ratio (0.75) and, c) relatively high shear force corresponding to moment capacity to shear capacity ratios between 0.60 and 0.80, were considered. The responses of specimens were specified in terms of the lateral load-displacement curves, stiffness variation, ductility ratios, damage progression, and energy dissipation. The experimental results demonstrated that in case the retrofitting method is properly applied, the strengthened columns exhibit satisfactory performance in terms of strength and ductility with a remarkable improvement with respect to the substandard columns. Furthermore, a numerical study was conducted to validate the experimental results by using the OpenSees framework.
  • Conference Object
    Modeling of Glycolysis
    (Elsevier Science Bv, 2016) Batur, Aysem; Hamamci, Haluk; Buyukkileci (Sahin), Ceylan; Buyukkileci, Ali Oguz
  • Article
    Citation - WoS: 36
    Search for Three-Jet Resonances in pp Collisions at √s=7 TeV
    (Elsevier, 2012) Chatrchyan, S.; Khachatryan, V.; Sirunyan, A. M.; Tumasyan, A.; Adam, W.; Aguilo, E.; Swanson, J.
    Results are reported from a search for the production of three-jet resonances in pp collisions at a center-of-mass energy root s = 7 TeV. The study uses the data sample collected by the CMS experiment at the LHC in 2011, corresponding to an integrated luminosity of 5.0 fb(-1). Events with high jet multiplicity and a large scalar sum of jet transverse momenta are analyzed for the presence of resonances in the three-jet invariant mass spectrum. No evidence for a narrow resonance is found in the data, and limits are set on the cross section for gluino pair production in an R-parity-violating supersymmetry model, for gluino masses greater than 280 GeV. Assuming a branching fraction for gluino decay into three jets of 100%, gluino masses below 460 GeV are excluded at 95% confidence level. These results significantly extend the range of previous limits. (C) 2012 CERN. Published by Elsevier By. All rights reserved.
  • Article
    Citation - WoS: 4
    Citation - Scopus: 2
    Elastic and Anelastic Behavior Associated With Structural Transitions in CsPbBr3
    (Amer Chemical Soc, 2025) Luo, Pingjing; He, Zhengwang; Yang, Dexin; Aktas, Oktay; Ding, Xiangdong; Zhang, Xuefeng
    Strain coupling and relaxation dynamics critically influence the photovoltaic and photoluminescent performances of metal halide perovskites. Here, resonant ultrasound spectroscopy is employed to study the elastic and anelastic properties associated with the octahedral tilting transitions in the optoelectronic semiconductor CsPbBr3 over the temperature range 303-468 K. The cubic-to-tetragonal transition near 405 K is marked by pronounced elastic softening accompanied by a sharp increase in acoustic loss. High anelastic loss below this transition reveals the presence of mobile ferroelastic twin walls that become pinned by lead vacancies at a temperature interval near 380 K in the tetragonal phase. The elastic softening in the cubic phase is strongly correlated to dynamic effects such as the local polar fluctuations. This local disordered effect is further verified by the anomalously high attenuation in the orthorhombic structure, in which the ferroelastic twin walls might become mobile.
  • Article
    Citation - WoS: 4
    Citation - Scopus: 2
    CFD-DEM Investigation of the Effects of Particle Size and Fluidization Regime on Heat Transfer in Fluidized Beds
    (Springer int Publ Ag, 2025) Alipoor, Mahdi; Kazemi, Saman; Zarghami, Reza; Mostoufi, Navid
    This paper presents an in-depth study of heat transfer in fluidized beds, employing the CFD-DEM technique. The primary focus is to examine the impacts of inlet gas velocity, fluidization regime, and particle size on the thermal behavior of fluidized beds. The results revealed that thermal convection predominantly governs heat transfer in fluidized beds, accounting for the largest fraction of the overall heat transfer process. Particle-fluid-particle thermal conduction was found to contribute approximately 10-20% of the heat transfer, whereas particle-particle conduction exhibits a minor role. Upon increasing the inlet gas velocity, the convection rate intensifies, whereas the particle-fluid-particle conduction rate decreases. Furthermore, the study highlights the differences in temperature distribution between turbulent and bubbling fluidized beds. Turbulent bed demonstrated a more uniform and homogenous particle temperature compared to bubbling. At similar fluidization numbers in bubbling beds, increasing particle diameter enhances thermal convection while reducing particle-fluid-particle conduction. In contrast, the turbulent regime shows minimal differences in heat transfer mechanisms when particle size varies. Additionally, smaller particles are found to significantly improve temperature uniformity in fluidized beds. A comprehensive comparison of simulation results with experimental data validates the accuracy of the employed model, reinforcing its ability to predict heat transfer in fluidized beds reliably. This research provides valuable insights into the complex interplay of various mechanisms of heat transfer within fluidized beds, enabling engineers and researchers to optimize bed performance and enhance temperature control in various industrial applications.