WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

Permanent URI for this collectionhttps://hdl.handle.net/11147/7150

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Author: search.filters.author.Bayraktar, OğuzPublisher: search.filters.publisher.Elsevier

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Now showing 1 - 4 of 4
  • Conference Object
    Citation - WoS: 2
    Incorporation of Equisetum Arvense Extract Into Silk Fibroin-Hyaluronic Acid Sponge Matrices for Wound Dressing Applications
    (Elsevier, 2012) Uslu, Mehmet Emin; Erdoğan, İpek; Bayraktar, Oğuz
    Equisetum arvense extract has frequently been investigated for its antioxidant capacity, antimicrobial and antitumor properties. However, one of the challenges in natural compound investi-gations is to maintain the stability of polyphenolic compounds during their storage and applications. For this purpose extracts can be incorporated into different forms of biomaterial. In this research silk fibroin (SF) and hyaluronic acid (HA) was used as sponge matri-ces for wound dressing application.
  • Conference Object
    In Vitro Antitumor Activity of Sarcopoterium Spinosum Leaf Extract With Bioactive Natural Compounds
    (Elsevier, 2013) Süngüç, Ceren; Erdoğan, İpek; Uslu, Mehmet Emin; Bayraktar, Oğuz
    Cancer cell lines cause generation of reactive oxygen species and free radicals at high levels (Wang and Yi, 2008). Then generated free radicals lead to breakdown of the structure of DNA, lipid or protein (Gul et al., 2011). When plant extracts including antioxidant phytochemicals are exposed to the redox reactions, the harmful effects of free radicals are effectively prevented. The aim of present research was to evaluate the antitumor potential of the extract derived from Sarcopoterium spinosum leaves. The leaves of S. spinosum were collected in Izmir, Turkey. Total phenol content of ethanolic.
  • Conference Object
    Investigation of Anti-Tumoral Activity of Cistus Creticus Extract Against Pc-3 Cell Line
    (Elsevier, 2013) Erdoğan, İpek; Süngüç, Ceren; Uslu, Mehmet Emin; Bayraktar, Oğuz
    Recent studies have revealed that plant extracts show cytotoxic activities against cancer cell lines by ceasing cell division in particular phases (Xu et al., 2012, Yıldırım et al., 2013). Expression of specific genes was found to be activated according to pathway in which cell death occurs. Objective of this study was to identify antitumoural effect of Cistus creticus, which is a perennial shrub, found in Mediterranean region, against prostate cancer cell line by measuring the cytotoxic activities and apoptotic gene expression levels.
  • Article
    Citation - WoS: 8
    Citation - Scopus: 10
    Ruscogenin Interacts With Dppc and Dppg Model Membranes and Increases the Membrane Fluidity: Ftir and Dsc Studies
    (Elsevier, 2023) Şahin, İpek; Ceylan, Çağatay; Bayraktar, Oğuz
    Ruscogenin, a kind of steroid saponin, has been shown to have significant anti-oxidant, anti-inflammatory, and anti-thrombotic characteristics. Furthermore, it has the potential to be employed as a medicinal medication to treat a variety of acute and chronic disorders. The interaction of a drug molecule with cell membranes can help to elucidate its system-wide protective and therapeutic effects, and it's also important for its pharmacological activity. The molecular mechanism by which ruscogenin affects membrane architecture is still a mystery. Ruscogenin's interaction with zwitterionic dipalmitoyl phosphatidylcholine (DPPC) and anionic dipalmitoyl phosphatidylglycerol (DPPG) multilamellar vesicles (MLVs) was studied utilizing two non-invasive approaches, including: Fourier Transform Infrared (FTIR) spectroscopy and Differential Scanning Calorimetry. Ruscogenin caused considerable alterations in the phase transition profile, order, dynamics and hydration state of head groups and glycerol backbone of DPPC and DPPG MLVs at all concentrations. The DSC results indicated that the presence of ruscogenin decreased the main phase transition temperature (Tm) and enthalpy (ΔH) values of both membranes and increased half height width of the main transition (ΔT1/2). The FTIR results demonstrated that all concentrations (1, 3, 6, 9, 15, 24 and 30 mol percent) of ruscogenin disordered the DPPC MLVs both in the gel and liquid crystalline phases while it increased the order of DPPG MLVs in the liquid crystalline phase. Moreover, ruscogenin caused an increase in the dynamics of DPPC and DPPG MLVs in both phases. Additionally, it enhanced the hydration of the head groups of lipids and the surrounding water molecules implying ruscogenin to interact strongly with both zwitterionic and charged model membranes.