WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

Permanent URI for this collectionhttps://hdl.handle.net/11147/7150

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Author: search.filters.author.Bulmuş Zareie, Volga

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  • Conference Object
    Role of Myelin Topography and Alignment on the Activation of Astrocytes
    (Mary Ann Liebert, Inc, 2017) Gürer, F.; Bulmuş Zareie, Volga; Bulmus Zareire, Esma Volga; Baskerville, K.; Özdemir, T.
    Myelin sheath is thick layers of neuronal plasma membrane that serves as a capacitor during neuronal signal transmission. Decay in myelin sheath is associated with several neurodegenerative diseases such as multiple sclerosis and Alzheimer disease. Although its primary purpose is to insulate and accelerate the neuronal impulse, very few studies focused on the geometrical aspect of myelination in neuronal function. Here, we developed a versatile platform to study the effect of myelin topography and alignment on the neuronal signal transmission.
  • Article
    Citation - WoS: 38
    Citation - Scopus: 38
    Ph- and Temperature-Responsive Amphiphilic Diblock Copolymers of 4-Vinylpyridine and Oligoethyleneglycol Methacrylate Synthesized by Raft Polymerization
    (Elsevier Ltd., 2014) Topuzogulları, Murat; Bulmuş Zareie, Volga; Bulmuş, Volga; Dalgakıran, Eray; Dinçer, Sevil
    Diblock copolymers of 4-vinylpyridine (4VP) and oligoethyleneglycol methyl ether methacrylate (OEGMA) were synthesized for the first time using RAFT polymerization technique as potential drug delivery systems. Effects of the number of ethylene glycol units in OEGMA, chain length of hydrophobic P4VP block, pH, concentration and temperature on the solution behavior of the copolymers were investigated comprehensively. Copolymer chains formed micelles at pH values higher than 5 whereas unimeric polymers were observed to exist below pH 5, owing to the repulsion between positively charged P4VP blocks. The size of the micelles was dependent on the relative length of blocks, P4VP and POEGMA. Thermo-responsive properties of copolymers were investigated depending on the pH and length of P4VP block. The increase in the length of P4VP block decreased the LCST substantially at pH 7. At pH 3, LCST of copolymers shifted to higher temperatures due to the increased interaction of copolymers with water through positively charged P4VP block.