WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

Permanent URI for this collectionhttps://hdl.handle.net/11147/7150

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Author: search.filters.author.Didikoglu, AltugCOAR Access Rights: search.filters.coarAccessRights.open access

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  • Review
    Citation - WoS: 24
    Citation - Scopus: 27
    Recommendations for Measuring and Standardizing Light for Laboratory Mammals To Improve Welfare and Reproducibility in Animal Research
    (Public Library Science, 2024) Lucas, Robert J.; Allen, Annette E.; Brainard, George C.; Brown, Timothy M.; Dauchy, Robert T.; Didikoglu, Altug; Peirson, Stuart N.
    Light enables vision and exerts widespread effects on physiology and behavior, including regulating circadian rhythms, sleep, hormone synthesis, affective state, and cognitive processes. Appropriate lighting in animal facilities may support welfare and ensure that animals enter experiments in an appropriate physiological and behavioral state. Furthermore, proper consideration of light during experimentation is important both when it is explicitly employed as an independent variable and as a general feature of the environment. This Consensus View discusses metrics to use for the quantification of light appropriate for nonhuman mammals and their application to improve animal welfare and the quality of animal research. It provides methods for measuring these metrics, practical guidance for their implementation in husbandry and experimentation, and quantitative guidance on appropriate light exposure for laboratory mammals. The guidance provided has the potential to improve data quality and contribute to reduction and refinement, helping to ensure more ethical animal use. Lighting conditions for laboratory mammals is currently set according to the sensitivity of human vision. This Consensus View defines alternative 'animal-centric' metrics and provides guidance for their application to standardize experimental conditions, improve animal welfare and the quality of animal research.
  • Article
    Citation - WoS: 33
    Citation - Scopus: 30
    Associations Between Light Exposure and Sleep Timing and Sleepiness While Awake in a Sample of Uk Adults in Everyday Life
    (Natl Acad Sciences, 2023) Didikoglu, Altug; Mohammadian, Navid; Johnson, Sheena; van Tongeren, Martie; Wright, Paul; Casson, Alexander J.; Lucas, Robert J.; Didikoğlu, Altuğ
    Experimental and interventional studies show that light can regulate sleep timing and sleepiness while awake by setting the phase of circadian rhythms and supporting alertness. The extent to which differences in light exposure explain variations in sleep and sleepiness within and between individuals in everyday life remains less clear. Here, we establish a method to address this deficit, incorporating an open- source wearable wrist -worn light logger (SpectraWear) and smartphone-based online data collection. We use it to simultaneously record longitudinal light exposure (in melanopic equivalent daylight illuminance), sleep timing, and subjective alertness over seven days in a convenience sample of 59 UK adults without externally imposed circadian challenge (e.g., shift work or jetlag). Participants reliably had strong daily rhythms in light exposure but frequently were exposed to less light during the daytime and more light in pre- bedtime and sleep episodes than recommended [T. M. Brown et al., PLoS Biol. 20, e3001571 (2022)]. Prior light exposure over several hours was associated with lower subjective sleepiness with, in particular, brighter light in the late sleep episode and after wake linked to reduced early morning sleepiness (sleep inertia). Higher pre- bedtime light exposure was associated with longer sleep onset latency. Early sleep timing was correlated with more reproducible and robust daily patterns of light exposure and higher daytime/lower night -time light exposure. Our study establishes a method for collecting longitudinal sleep and health/performance data in everyday life and provides evidence of associations between light exposure and important determinants of sleep health and performance.