WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

Permanent URI for this collectionhttps://hdl.handle.net/11147/7150

Browse

Filters

2025 - 20262

Settings

Author: search.filters.author.Kazemi, SamanPublisher: search.filters.publisher.Elsevier

Search Results

Now showing 1 - 2 of 2
  • Article
    CFD-DEM Investigation on Particle Separation from Fluid Flow Using Magnetic Fields
    (Elsevier, 2026) Morsali, Shaghayegh; Kazemi, Saman; Farahani, Farhang Jalali; Zarghami, Reza
    This study presents a numerical simulation of magnetic particle separation from fluid flow using CFD-DEM modeling. Studies have shown that magnetic fields are an effective tool for particle separation, especially on small scales, and variables such as magnetic field intensity, fluid velocity, and particle size significantly impact separation efficiency. Other factors, such as the initial location of particles and their density, were also examined, and their effect on the attraction of particles was determined. The magnetic field was applied through a line dipole in the fluid channel. The simulation results show that particles accumulate in the channel area where the line dipole is located, with higher particle concentration at the beginning of the dipole compared to other sections. Additionally, the results indicate that increasing the magnetic field intensity significantly improves separation efficiency, while increasing fluid velocity can decrease this efficiency. At a velocity of 0.2 m per second, results showed that increasing the magnetic field intensity from 0.6 to 3 T improved the capture efficiency from 69 % to 91 %. Similarly, at a magnetic field intensity of 1 T, reducing the fluid velocity from 0.3 to 0.1 m per second doubled the capture efficiency. In the optimal state, combining maximum field intensity with minimum velocity can achieve an efficiency of 98 %. It was also observed that larger particle diameters and higher densities have a positive effect on particle attraction.
  • Article
    Citation - WoS: 4
    Citation - Scopus: 3
    Exploration of Electrostatics Effect on Dispersion and Coating Mechanisms in Dry Powder Inhalers by Discrete Element Method
    (Elsevier, 2025) Saeid, Pooya; Kazemi, Saman; Zarghami, Reza; Sotudeh-Gharebagh, Rahmat; Mostoufi, Navid
    Improving drug delivery in the respiratory system relies on the effective coating and dispersion of active pharmaceutical ingredients (APIs) in dry powder inhalers (DPIs) and the respiratory system's airways. This study aims to explore the impact of different factors on coating APIs on carrier particles, considering electrostatic and van der Waals forces using the discrete element method (DEM). This study focuses on the critical elements of API dispersion, specifically collisions between API-coated carrier particles with each other and DPI walls. The factors influencing the dispersion ratio in these collisions, such as impact velocity, contact angle, and particle charge, are examined. Additionally, a reduced-scale shaking DPI with three frequencies is used to investigate the API coating mechanism on carriers, which was not explored in previous studies. The difference in work function between carrier particles and APIs generates charge in the shaking DPI due to collisions. This causes electrostatic force to dominate over van der Waals force, breaking agglomerates and attaching APIs to carrier particles. This study shows that the amount of generated charge increases with particle collisions and that charge distribution becomes more balanced over time through charge exchange between particles. By elucidating the relationships among impact velocity, dispersion ratio, shaking frequency, and contact angles, this study paves the way for future research on more efficient DPI designs.